{"id":231175,"date":"2018-07-17T23:42:43","date_gmt":"2018-07-18T06:42:43","guid":{"rendered":"https:\/\/nai500.com\/?p=231175"},"modified":"2018-07-17T23:42:43","modified_gmt":"2018-07-18T06:42:43","slug":"%e7%94%9f%e7%89%a9%e6%8a%80%e6%9c%af%e5%85%ac%e5%8f%b8hotspot%e5%ae%8c%e6%88%904500%e4%b8%87%e7%be%8e%e5%85%83a%e8%bd%ae%e8%9e%8d%e8%b5%84%ef%bc%8c%e6%8e%a8%e8%bf%9b%e5%8f%98%e6%9e%84%e8%8d%af","status":"publish","type":"post","link":"https:\/\/nai500.com\/zh-hans\/blog\/2018\/07\/%e7%94%9f%e7%89%a9%e6%8a%80%e6%9c%af%e5%85%ac%e5%8f%b8hotspot%e5%ae%8c%e6%88%904500%e4%b8%87%e7%be%8e%e5%85%83a%e8%bd%ae%e8%9e%8d%e8%b5%84%ef%bc%8c%e6%8e%a8%e8%bf%9b%e5%8f%98%e6%9e%84%e8%8d%af\/","title":{"rendered":"\u751f\u7269\u6280\u672f\u516c\u53f8HotSpot\u5b8c\u62104500\u4e07\u7f8e\u5143A\u8f6e\u878d\u8d44\uff0c\u63a8\u8fdb\u53d8\u6784\u836f\u7269\u53d1\u73b0\u7684\u65b0\u65b9\u6cd5"},"content":{"rendered":"

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HotSpot \u516c\u53f8\u5f00\u53d1\u4e86\u4e13\u6709\u7684SpotFinder\u2122\u6280\u672f\u5e73\u53f0\uff0c\u80fd\u591f\u7cfb\u7edf\u6027\u5730\u53d1\u73b0\u548c\u9776\u5411\u8c03\u8282\u86cb\u767d\u529f\u80fd\u7684\u53d8\u6784 (allosteric) \u4f4d\u70b9\uff0c\u5e76\u4e14\u901a\u8fc7\u9776\u5411\u8fd9\u4e9b\u4f4d\u70b9\u5f00\u53d1\u51fa\u4e00\u6d41\u7684\u521b\u65b0\u836f\u7269\u3002HotSpot \u516c\u53f8\u662f\u7b2c\u4e00\u5bb6\u7cfb\u7edf\u5730\u5229\u7528\u81ea\u7136\u8c03\u63a7\u70ed\u70b9(regulatory hotspots)\u8fdb\u884c\u53d8\u6784\u836f\u7269\u53d1\u73b0\u7684\u4f01\u4e1a\u3002<\/p>\n

HotSpot\u516c\u53f8\u8054\u5408\u521b\u59cb\u4eba\u517c\u9996\u5e2d\u6267\u884c\u5b98Jonathan Montagu\u5148\u751f\u8bf4\uff1a\u201cHotSpot\u516c\u53f8\u9776\u5411\u7684\u662f\u86cb\u767d\u7ecf\u8fc7\u4e0a\u767e\u4e07\u5e74\u7684\u8fdb\u5316\u8fc7\u7a0b\u5e76\u5f97\u4ee5\u4f18\u5316\u7684\u5929\u7136\u8c03\u63a7\u4f4d\u70b9\u3002\u8fd9\u4e00\u7b56\u7565\u8ba9\u6211\u4eec\u80fd\u591f\u5f00\u53d1\u4f7f\u7528\u540c\u6837\u8c03\u63a7\u673a\u5236\u7684\u521b\u65b0\u836f\u7269\uff0c\u5b83\u4eec\u5177\u5907\u540c\u6837\u7684\u7cbe\u786e\u6027\u548c\u6548\u529b\u3002\u8c03\u63a7\u70ed\u70b9\u5728\u836f\u7269\u7814\u53d1\u8fc7\u7a0b\u4e2d\u8fd8\u672a\u88ab\u5f00\u53d1\uff0c\u5b83\u4eec\u4ee3\u8868\u7740\u5728\u591a\u79cd\u75be\u75c5\u9886\u57df\u4e2d\u53d1\u73b0\u5168\u65b0\u4e00\u6d41\u836f\u7269\u7684\u91cd\u5927\u673a\u9047\u3002\u201d<\/p>\n

\u82f1\u6587\u6765\u6e90\uff1aBiospace<\/p>\n","protected":false},"excerpt":{"rendered":"

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