{"id":242705,"date":"2018-10-17T19:00:03","date_gmt":"2018-10-18T02:00:03","guid":{"rendered":"https:\/\/nai500.com\/?p=242705"},"modified":"2018-10-19T00:38:54","modified_gmt":"2018-10-19T07:38:54","slug":"%e4%b8%ad%e5%9b%bd%e5%ba%b7%e5%ae%81%e6%9d%b0%e7%91%9eher2%e5%8f%8c%e7%89%b9%e5%bc%82%e6%80%a7%e6%8a%97%e4%bd%93kn026%e8%8e%b7%e7%be%8e%e5%9b%bdfda%e9%a2%81%e5%8f%91%e4%b8%b4%e5%ba%8a%e8%af%95","status":"publish","type":"post","link":"https:\/\/nai500.com\/zh-hans\/blog\/2018\/10\/%e4%b8%ad%e5%9b%bd%e5%ba%b7%e5%ae%81%e6%9d%b0%e7%91%9eher2%e5%8f%8c%e7%89%b9%e5%bc%82%e6%80%a7%e6%8a%97%e4%bd%93kn026%e8%8e%b7%e7%be%8e%e5%9b%bdfda%e9%a2%81%e5%8f%91%e4%b8%b4%e5%ba%8a%e8%af%95\/","title":{"rendered":"\u4e2d\u56fd\u5eb7\u5b81\u6770\u745eHER2\u53cc\u7279\u5f02\u6027\u6297\u4f53KN026\u83b7\u7f8e\u56fdFDA\u9881\u53d1\u4e34\u5e8a\u8bd5\u9a8c\u6279\u4ef6"},"content":{"rendered":"<p class=\"p1\"><span class=\"s1\">\u6c5f\u82cf\u5eb7\u5b81\u6770\u745e\u751f\u7269\u5236\u836f\u6709\u9650\u516c\u53f8\uff08\u4ee5\u4e0b\u7b80\u79f0\uff1a\u6c5f\u82cf\u5eb7\u5b81\u6770\u745e\uff09\u8fd1\u65e5\u5ba3\u5e03\uff0c\u5176\u81ea\u4e3b\u7814\u53d1\u7684<\/span><span class=\"s2\">HER2<\/span><span class=\"s1\">\u53cc\u7279\u5f02\u6027\u6297\u4f53<\/span><span class=\"s2\"> (<\/span><span class=\"s1\">\u4ea7\u54c1\u4ee3\u7801<\/span><span class=\"s2\">:KN026<\/span><span class=\"s1\">\uff09\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\u5df2\u83b7\u5f97\u7f8e\u56fd<\/span><span class=\"s2\">FDA<\/span><span class=\"s1\">\u6279\u51c6\uff0c\u9884\u671f\u4e0d\u4e45\u5c06\u542f\u52a8\u7f8e\u56fd\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/span><\/p>\n<p class=\"p1\"><span class=\"s2\">KN026<\/span><span class=\"s1\">\u662f\u6c5f\u82cf\u5eb7\u5b81\u6770\u745e\u91c7\u7528\u5177\u6709\u81ea\u4e3b\u77e5\u8bc6\u4ea7\u6743\u7684<\/span><span class=\"s2\">Fc <\/span><span class=\"s1\">\u5f02\u4e8c\u805a\u4f53\u5e73\u53f0\u6280\u672f\uff08<\/span><span class=\"s2\">CRIB<\/span><span class=\"s1\">\uff09\u5f00\u53d1\u7684<\/span><span class=\"s2\">HER2<\/span><span class=\"s1\">\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff0c\u8bc6\u522b<\/span><span class=\"s2\">HER2<\/span><span class=\"s1\">\u4e0a\u7684\u4e24\u4e2a\u4e0d\u540c\u8868\u4f4d\u3002<\/span><span class=\"s2\">KN026<\/span><span class=\"s1\">\u5206\u5b50\u7684\u5927\u5c0f\u548c\u5f62\u72b6\u4e0e\u5929\u7136<\/span><span class=\"s2\">IgG<\/span><span class=\"s1\">\u6297\u4f53\u76f8\u540c\u3002<\/span><span class=\"s2\">KN026<\/span><span class=\"s1\">\u91c7\u7528\u5e38\u89c4\u6297\u4f53\u751f\u4ea7\u5de5\u827a\uff0c\u8be5\u8fc7\u7a0b\u5df2\u901a\u8fc7\u591a\u4e2a\u5927\u89c4\u6a21\uff08\u6700\u591a<\/span><span class=\"s2\">1,000<\/span><span class=\"s1\">\u5347\uff09\u6279\u6b21\u8fdb\u884c\u9a8c\u8bc1\u3002<\/span><\/p>\n<p class=\"p1\"><span class=\"s2\">KN026<\/span><span class=\"s1\">\u5728\u7ed3\u5408\u4eb2\u548c\u529b\u3001\u529f\u6548\u3001\u5b89\u5168\u6027\u548c\u836f\u4ee3\u52a8\u529b\u5b66\u65b9\u9762\u8868\u73b0\u51fa\u4f18\u5f02\u7684\u4e34\u5e8a\u524d\u7279\u6027\u3002\u4e0e\u66f2\u59a5\u73e0\u5355\u6297\u548c<\/span><span class=\"s2\">Pertuzumab<\/span><span class=\"s1\">\u7684\u8054\u5408\u7528\u836f\u76f8\u6bd4\uff0c\u5b83\u5728\u7ea6<\/span><span class=\"s2\">40<\/span><span class=\"s1\">\uff05\u7684<\/span><span class=\"s2\">HER2 +<\/span><span class=\"s1\">\u80bf\u7624\u7ec6\u80de\u7cfb\u548c\u591a\u79cd\u4f53\u5185\u80bf\u7624\u6a21\u578b\u4e2d\u663e\u793a\u51fa\u66f4\u597d\u7684\u529f\u6548\u6d3b\u6027\u3002<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">\u6c5f\u82cf\u5eb7\u5b81\u6770\u745e\u8463\u4e8b\u957f\u517c\u9996\u5e2d\u6267\u884c\u5b98\u5f90\u9706\u535a\u58eb\u8868\u793a\uff1a<\/span><span class=\"s2\">\u201c<\/span><span class=\"s1\">\u6211\u4eec\u975e\u5e38\u9ad8\u5174<\/span><span class=\"s2\">KN026<\/span><span class=\"s1\">\u5728\u7f8e\u56fd\u83b7\u5f97\u4e34\u5e8a\u8bd5\u9a8c\u6279\u51c6\uff0c\u8fd9\u6807\u5fd7\u7740\u5eb7\u5b81\u6770\u745e\u7684\u53cc\u7279\u5f02\u6027\u6297\u4f53\u5df2\u8d62\u5f97\u4e86<\/span><span class=\"s2\">FDA<\/span><span class=\"s1\">\u7684\u521d\u6b65\u8ba4\u53ef\uff1b\u8fd9\u4e5f\u662f\u9996\u4f8b\u7531\u4e2d\u56fd\u751f\u7269\u6280\u672f\u516c\u53f8\u7814\u53d1\u7684\u53cc\u7279\u5f02\u6027\u6297\u4f53\u521b\u65b0\u836f\u5728\u7f8e\u56fd\u83b7\u5f97\u4e34\u5e8a\u8bd5\u9a8c\u6279\u51c6\u3002\u57fa\u4e8e\u8fd9\u4e00\u5168\u7403\u9886\u5148\u7684\u53cc\u7279\u5f02\u6027\u6297\u4f53\u5e73\u53f0\uff0c\u6211\u4eec\u671f\u5f85\u4e0e\u56fd\u5185\u5916\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\u8fdb\u884c\u5408\u4f5c\uff0c\u5f00\u53d1\u51fa\u66f4\u591a\u4f18\u8d28\u7684\u53cc\u7279\u5f02\u6027\u6297\u4f53\u836f\u7269\u3002<\/span><span class=\"s2\">\u201d<\/span><\/p>\n<p class=\"p3\"><span class=\"s3\">\u82f1\u6587\u6765\u6e90\uff1a<\/span><span class=\"s1\">Biospace<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6c5f\u82cf\u5eb7\u5b81\u6770\u745e\u751f\u7269\u5236\u836f\u6709\u9650\u516c\u53f8\uff08\u4ee5\u4e0b\u7b80\u79f0\uff1a\u6c5f\u82cf\u5eb7\u5b81\u6770\u745e\uff09\u8fd1\u65e5\u5ba3\u5e03\uff0c\u5176\u81ea\u4e3b\u7814\u53d1\u7684HER2\u53cc\u7279\u5f02\u6027\u6297\u4f53 (\u4ea7\u54c1\u4ee3\u7801: 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