{"id":277390,"date":"2019-07-10T00:00:00","date_gmt":"2019-07-10T07:00:00","guid":{"rendered":"http:\/\/62.151.178.150\/blog\/2019\/07\/revolution-medicines%e5%9c%a8c%e8%bd%ae%e8%9e%8d%e8%b5%84%e4%b8%ad%e7%ad%b9%e8%b5%841%e4%ba%bf\/"},"modified":"2019-07-10T00:00:00","modified_gmt":"2019-07-10T07:00:00","slug":"revolution-medicines%e5%9c%a8c%e8%bd%ae%e8%9e%8d%e8%b5%84%e4%b8%ad%e7%ad%b9%e8%b5%841%e4%ba%bf","status":"publish","type":"post","link":"https:\/\/nai500.com\/zh-hans\/blog\/2019\/07\/revolution-medicines%e5%9c%a8c%e8%bd%ae%e8%9e%8d%e8%b5%84%e4%b8%ad%e7%ad%b9%e8%b5%841%e4%ba%bf\/","title":{"rendered":"Revolution Medicines\u5728C\u8f6e\u878d\u8d44\u4e2d\u7b79\u8d44$1\u4ebf"},"content":{"rendered":"<p class=\"p1\"><span class=\"s1\">\u6e7e\u533a\u7684Revolution Medicines\u83b7\u5f97\u4e861\u4ebf\u7f8e\u5143\u7684C\u8f6e\u878d\u8d44\uff0c\u7528\u4e8e\u652f\u6301\u516c\u53f8\u9488\u5bf9RAS\u9014\u5f84\u7684\u836f\u54c1\u5f00\u53d1\uff0c\u5305\u62ec\u5176\u4e3b\u8981\u4e34\u5e8a\u5019\u9009\u836f\u7269\u3002<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Revolution Medicines\u6b63\u5728\u5f00\u53d1RMC-4630\uff0c\u8fd9\u662f\u4e00\u79cd\u6709\u6548\u7684\u3001\u53e3\u670d\u751f\u7269\u53ef\u5229\u7528\u7684\u5c0f\u5206\u5b50\uff0c\u53ef\u9009\u62e9\u6027\u5730\u6291\u5236SHP2\u7684\u6d3b\u6027\u3002SHP2\u662f\u4e00\u79cd\u901a\u8fc7RAS\u9014\u5f84\u8c03\u8282\u7ec6\u80de\u751f\u957f\u4fe1\u53f7\u4f20\u5bfc\u6d3b\u6027\u7684\u6838\u5fc3\u86cb\u767d\u3002 RAS\u9014\u5f84\uff0c\u4e5f\u79f0\u4e3aMAPK \/ ERK\u9014\u5f84\uff0c\u662f\u7ec6\u80de\u5185\u7684\u4e00\u7ec4\u86cb\u767d\u8d28\uff0c\u80fd\u5c06\u4fe1\u53f7\u4ece\u7ec6\u80de\u8868\u9762\u53d7\u4f53\u53d1\u9001\u81f3\u7ec6\u80de\u6838\u4e2d\u7684DNA\u3002 SHP2\u5728\u591a\u79cd\u5f62\u5f0f\u7684\u764c\u75c7\u548c\u8c03\u8282\u514d\u75ab\u7cfb\u7edf\u4e2d\u8d77\u91cd\u8981\u4f5c\u7528\u3002Revolution Medicines\u4e00\u76f4\u81f4\u529b\u4e8e\u901a\u8fc7RAS-MAP\u6fc0\u9176\u9014\u5f84\u8c03\u8282SHP2\u3002SHP2\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5242\u53ef\u4ee5\u51cf\u5c11\u81f4\u7624\u4f5c\u7528\u3002Revolution Medicines\u6b63\u5728\u4e0e\u8d5b\u8bfa\u83f2\u5408\u4f5c\u5f00\u53d1RMC-4630\u3002\u76ee\u524d\u6b63\u5728\u9488\u5bf9\u4e00\u7cfb\u5217\u5177\u6709\u7279\u5b9a\u81f4\u764c\u7a81\u53d8\u7684\u80bf\u7624\u7c7b\u578b\u7684I \/ II\u671f\u8bd5\u9a8c\u4e2d\u8bc4\u4f30\u8be5\u836f\u7269\u3002<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Revolution Medicines\u603b\u88c1\u517c\u9996\u5e2d\u6267\u884c\u5b98Mark A. 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