{"id":300393,"date":"2019-10-30T17:57:29","date_gmt":"2019-10-31T00:57:29","guid":{"rendered":"https:\/\/nai500.com\/?p=300393"},"modified":"2019-10-30T17:57:29","modified_gmt":"2019-10-31T00:57:29","slug":"%e5%9f%ba%e5%9b%a0%e7%bc%96%e8%be%91%e5%85%ac%e5%8f%b8crispr-therapeutics%e8%82%a1%e4%bb%b7%e6%9c%89%e6%9c%9b%e5%86%8d%e6%ac%a1%e5%88%9b%e5%87%ba%e6%96%b0%e9%ab%98%e7%9a%843%e4%b8%aa%e7%90%86%e7%94%b1","status":"publish","type":"post","link":"https:\/\/nai500.com\/zh-hans\/blog\/2019\/10\/%e5%9f%ba%e5%9b%a0%e7%bc%96%e8%be%91%e5%85%ac%e5%8f%b8crispr-therapeutics%e8%82%a1%e4%bb%b7%e6%9c%89%e6%9c%9b%e5%86%8d%e6%ac%a1%e5%88%9b%e5%87%ba%e6%96%b0%e9%ab%98%e7%9a%843%e4%b8%aa%e7%90%86%e7%94%b1\/","title":{"rendered":"\u57fa\u56e0\u7f16\u8f91\u516c\u53f8CRISPR Therapeutics\u80a1\u4ef7\u6709\u671b\u518d\u6b21\u521b\u51fa\u65b0\u9ad8\u76843\u4e2a\u7406\u7531"},"content":{"rendered":"

\u7f8e\u56fd\u9886\u5148\u7684\u57fa\u56e0\u7f16\u8f91\u516c\u53f8CRISPR Therapeutics AG\uff08NASDAQ: CRSP\uff09<\/a>\u80a1\u4ef72019\u5e74\u4e0a\u6da852%\uff0c\u4f46\u8f83\u51762018\u5e74\u521b\u51fa\u7684\u7eaa\u5f55\u9ad8\u4ef7\u4ecd\u4f4e40%\u3002\u4e0d\u8fc7\uff0c\u516c\u53f8\u53d1\u5e03\u7684\u4e09\u5b63\u62a5\u7684\u5f53\u4e2d\uff0c\u7ba1\u7406\u5c42\u5f3a\u8c03\u4e86\u6709\u671b\u9a71\u52a8\u8be5\u751f\u7269\u79d1\u6280\u80a1\u80a1\u4ef7\u518d\u6b21\u521b\u51fa\u65b0\u9ad8\u7684\u6570\u4e2a\u50ac\u5316\u5242\u3002<\/p>\n

1.\u00a0\u00a0 \u57fa\u56e0\u7f16\u8f91\u9020\u8840\u5e72\u7ec6\u80de\u7597\u6cd5CTX001\u7684\u7ed3\u679c\u5373\u5c06\u516c\u5e03<\/h2>\n

\u4eca\u5e742\u6708\uff0cCRISPR Therapeutics\u8054\u5408\u798f\u6cf0\u5236\u836fVertex Pharmaceuticals\uff08NASDAQ: VRTX\uff09<\/a>\u5bf9\u5916\u5ba3\u5e03\uff0c\u57fa\u56e0\u7f16\u8f91\u9020\u8840\u5e72\u7ec6\u80de\u7597\u6cd5CTX001\u542f\u52a8\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u76ee\u524d\u5df2\u6709\u9996\u4f8b\u60a3\u8005\u63a5\u53d7\u6cbb\u7597\u3002\u4e24\u5bb6\u516c\u53f8\u5206\u522b\u5f00\u5c55\u4e24\u9879\u8bd5\u9a8c\u8bc4\u4f30CTX001\uff0c\u4e00\u9879\u8bd5\u9a8c\u7684\u53d7\u8bd5\u8005\u662f\u8f93\u8840\u4f9d\u8d56\u6027\u5730\u4e2d\u6d77\u8d2b\u8840\uff08TDT\uff09\u60a3\u8005\uff0c\u53e6\u4e00\u9879\u662f\u4e25\u91cd\u7684\u9570\u72b6\u7ec6\u80de\u75c5\uff08SCD\uff09\u60a3\u8005\u3002\u8fd9\u4e24\u79cd\u75be\u75c5\u5747\u7531\u8840\u7ea2\u86cb\u767d\u57fa\u56e0\u7f3a\u9677\u5bfc\u81f4\uff0c\u60a3\u8005\u9700\u8981\u9891\u7e41\u8fdb\u884c\u8f93\u8840\u3002<\/p>\n

CTX001\u901a\u8fc7\u526a\u5207BCL11A\u57fa\u56e0\uff08\u6291\u5236\u80ce\u513f\u8840\u7ea2\u86cb\u767d\u7684\u4ea7\u751f\uff09\u5b9e\u73b0\u6cbb\u7597\u76ee\u7684\uff0c\u8bd5\u9a8c\u4eba\u5458\u4ece\u60a3\u8005\u4f53\u5185\u53d6\u51fa\u9020\u8840\u5e72\u7ec6\u80de\uff0c\u5728\u4f53\u5916\u5bf9\u5176\u8fdb\u884c\u7f16\u8f91\uff0c\u7136\u540e\u518d\u6ce8\u5165\u60a3\u8005\u4f53\u5185\uff0c\u7f16\u8f91\u540e\u7684\u5e72\u7ec6\u80de\u80fd\u591f\u751f\u6210\u8db3\u591f\u80ce\u513f\u8840\u7ea2\u86cb\u767d\u7684\u7ea2\u7ec6\u80de\uff0c\u4ece\u800c\u51cf\u5c11\u60a3\u8005\u5bf9\u4e8e\u8f93\u8840\u7684\u4f9d\u8d56\u3002<\/p>\n

CRISPR Therapeutics\u5c06\u5728\u5e74\u5e95\u524d\uff0c\u6700\u6709\u53ef\u80fd\u662f\u572812\u6708\u4e3e\u884c\u7684\u7f8e\u56fd\u8840\u6db2\u5b66\u4f1a\uff08ASH\uff09\u5e74\u4f1a\u4e0a\u516c\u5e03CTX001\u7684\u521d\u671f\u7ed3\u679c\u3002\u5982\u679c\u8bd5\u9a8c\u7ed3\u679c\u76f8\u8f83Bluebird bio Inc\uff08NASDAQ: BLUE\uff09<\/a>\u7684\u65b0\u578b\u57fa\u56e0\u7597\u6cd5LentiGlobin\u5177\u5907\u7ade\u4e89\u529b\uff0cCRISPR Therapeutics\u6709\u671b\u6210\u4e3a\u4eca\u5e74\u751f\u7269\u79d1\u6280\u9886\u57df\u7684\u4e00\u53ea\u5927\u725b\u80a1\u3002<\/p>\n

2.\u00a0\u00a0 \u540c\u79cd\u5f02\u4f53CAR-T\u7ec6\u80de\u7597\u6cd5\uff1a\u764c\u75c7\u6cbb\u7597\u7684\u65b0\u9014\u5f84<\/h2>\n

CRISPR Therapeutics\u7684\u540c\u79cd\u5f02\u4f53CAR-T\u7ec6\u80de\u7597\u6cd5CTX110\u5df2\u7ecf\u5f00\u59cb\u6cbb\u7597\u764c\u75c7\u60a3\u8005\u3002\u8ddf\u5409\u5229\u5fb7\u79d1\u5b66Gilead Sciences\uff08NASDAQ: GILD\uff09<\/a>\u7684CAR-T\u7ec6\u80de\u7597\u6cd5Yescarta\u4e0d\u540c\u7684\u662f\uff0c\u5c3d\u7ba1\u4e24\u79cd\u7597\u6cd5\u5747\u7531\u9776\u5411CD19\u7684\u514d\u75ab\u7ec6\u80de\u5236\u6210\uff0c\u4f46Yescarta\u5c5e\u4e8e\u81ea\u4f53\u7ec6\u80de\u7597\u6cd5\uff0c\u6210\u672c\u6548\u76ca\u4e0d\u9ad8\uff0c\u9500\u552e\u60c5\u51b5\u4e5f\u4e0d\u5982\u4eba\u610f\u3002<\/p>\n

\u5982\u679cCTX110\u7684\u7ed3\u679c\u79ef\u6781\uff0c\u8be5\u540c\u79cd\u5f02\u4f53\u7ec6\u80de\u7597\u6cd5\u5bf9\u4e8eCRISPR\u80a1\u4ef7\u7684\u63d0\u632f\u4f5c\u7528\u751a\u81f3\u8981\u9ad8\u4e8eCTX001\uff0c\u539f\u56e0\u6709\u4e8c\uff1a\u8ddfCTX001\u4e0d\u540c\u7684\u662f\uff0cCRISPR Therapeutics\u5b8c\u5168\u638c\u63e1\u764c\u75c7\u9879\u76ee\uff0c\u56e0\u6b64\u65e0\u9700\u8ddf\u798f\u6cf0\u5236\u836f\u6216\u5176\u4ed6\u5236\u836f\u5546\u5206\u4eab\u5229\u6da6\u3002\u53e6\u5916\uff0c\u9776\u5411BCMA\u7684CTX120\u7684\u4e34\u5e8a\u8bd5\u9a8c\u5c06\u4e8e2020\u5e74\u4e0a\u534a\u5e74\u542f\u52a8\uff0c\u7b2c\u4e09\u6b3e\u9776\u5411CD70\u7684\u540c\u79cd\u5f02\u4f53\u7ec6\u80de\u7597\u6cd5\u4e5f\u5c06\u5728\u4e0d\u4e45\u4e4b\u540e\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n

3.\u00a0\u00a0 \u540c\u79cd\u5f02\u4f53\u5e72\u7ec6\u80de\u7597\u6cd5\uff1a\u7cd6\u5c3f\u75c5\u6cbb\u7597\u7684\u65b0\u9014\u5f84<\/h2>\n

\u53bb\u5e749\u6708\uff0cCRISPR\u548c\u79c1\u4eba\u516c\u53f8ViaCyte\u8fbe\u6210\u6218\u7565\u5408\u4f5c\uff0c\u53cc\u65b9\u5c06\u5171\u540c\u5f00\u53d1\u6cbb\u7597\u4e00\u578b\u7cd6\u5c3f\u75c5\u7684\u540c\u79cd\u5f02\u4f53\u5e72\u7ec6\u80de\u4ea7\u54c1\u3002\u76ee\u524d\u5168\u7403\u8303\u56f4\u5185\u7684\u4e00\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u4eba\u6570\u8d85\u8fc72000\u4e07\uff0c\u7531\u4e8e\u80f0\u5c9b\u7ec6\u80de\u7684\u529f\u80fd\u7834\u574f\uff0c\u60a3\u8005\u9700\u8981\u957f\u671f\u4f9d\u8d56\u80f0\u5c9b\u7d20\u8fdb\u884c\u6cbb\u7597\u3002\u5c06\u5065\u5eb7\u4e2a\u4f53\u7684\u80f0\u5c9b\u7d20\u751f\u6210\u7ec6\u80de\u79fb\u690d\u81f3\u60a3\u8005\u7684\u80f0\u817a\uff0c\u8fd9\u662f\u4e00\u6761\u53ef\u884c\u7684\u6cbb\u7597\u65b9\u6848\uff0c\u4f46\u7531\u4e8e\u5b58\u5728\u6392\u65a5\u53cd\u5e94\uff0c\u8fd9\u6837\u7684\u624b\u672f\u76f8\u5f53\u7f55\u89c1\u3002<\/p>\n

\u6b64\u6b21\u5f00\u53d1\u7684\u8fd9\u79cd\u5e72\u7ec6\u80de\u80fd\u591f\u751f\u6210\u80f0\u5c9b\u7d20\u548c\u8868\u9762\u86cb\u767dPD-L1\uff0c\u540c\u65f6\u80fd\u591f\u9003\u9038\u4eba\u4f53\u7684\u514d\u75ab\u7cfb\u7edf\u653b\u51fb\u3002\u5728\u57f9\u517b\u76bf\u5f53\u4e2d\uff0c\u8fd9\u4e9b\u5e72\u7ec6\u80de\u4f3c\u4e4e\u80fd\u591f\u8fdb\u884c\u81ea\u6211\u4fdd\u62a4\u3002\u5982\u679c\u5728\u8f6c\u79fb\u81f3\u80f0\u817a\u4e2d\u4e4b\u540e\u4ecd\u5177\u5907\u8fd9\u4e00\u80fd\u529b\uff0cCRISPR\u5c06\u80fd\u591f\u529f\u80fd\u6027\u6cbb\u6108\u4e00\u578b\u7cd6\u5c3f\u75c5\u3002<\/p>\n

\u9700\u8981\u6ce8\u610f\u7684\u98ce\u9669<\/h2>\n

\u5b9e\u9a8c\u5ba4\u8bc1\u660e\u67d0\u79cd\u7597\u6cd5\u7b26\u5408\u9884\u671f\u53ea\u662f\u7b2c\u4e00\u6b65\uff0c\u5e76\u4e0d\u4ee3\u8868\u5c06\u5728\u4eba\u4f53\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u4e5f\u80fd\u53d6\u5f97\u6210\u529f\u3002\u6b64\u5916\uff0c\u6295\u8d44\u8005\u9700\u8981\u505a\u597dCVX001\u548cCVX110\u7684\u65e9\u671f\u7ed3\u679c\u4e0d\u5982\u4eba\u610f\u7684\u5fc3\u7406\u51c6\u5907\uff0c\u56e0\u4e3a\u627e\u5230\u5408\u9002\u6570\u91cf\u7684\u7ec6\u80de\u7528\u4e8e\u8bd5\u9a8c\u6027\u6cbb\u7597\u662f\u4e00\u79cd\u4e0d\u65ad\u8bd5\u9519\u7684\u8fc7\u7a0b\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u7f8e\u56fd\u9886\u5148\u7684\u57fa\u56e0\u7f16\u8f91\u516c\u53f8CRISPR Therapeutics AG\uff08NASDAQ: CRSP\uff09\u80a1\u4ef72019\u5e74\u4e0a […]<\/p>\n","protected":false},"author":27,"featured_media":300394,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[1521,430],"tags":[820,455,747,925,459],"class_list":["post-300393","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-1521","category-trends-strategies-zh-hans","tag-820","tag-455","tag-747","tag-925","tag-459","sectors-life-science-zh-hans","locations-us-zh-hans","exchange-nasdaq-zh-hans"],"acf":[],"_links":{"self":[{"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/posts\/300393","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/users\/27"}],"replies":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/comments?post=300393"}],"version-history":[{"count":0,"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/posts\/300393\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/media\/300394"}],"wp:attachment":[{"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/media?parent=300393"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/categories?post=300393"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/tags?post=300393"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}