{"id":309564,"date":"2019-12-12T17:58:16","date_gmt":"2019-12-13T01:58:16","guid":{"rendered":"https:\/\/nai500.com\/blog\/2019\/12\/zhejiang-medicine-and-ambrx-present-positive-top-line-data-from-a-phase-1a-1b-clinical-trial-of-arx788-in-metastatic-her2-positive-breast-cancer\/"},"modified":"2019-12-12T17:58:34","modified_gmt":"2019-12-13T01:58:34","slug":"%e6%b5%99%e6%b1%9f%e5%8c%bb%e8%8d%af%e5%92%8c-ambrx-%e7%9a%84-arx788-%e4%b8%b4%e5%ba%8a%e8%af%95%e9%aa%8c%e8%8e%b7%e7%a7%af%e6%9e%81%e6%95%b0%e6%8d%ae","status":"publish","type":"post","link":"https:\/\/nai500.com\/zh-hans\/blog\/2019\/12\/%e6%b5%99%e6%b1%9f%e5%8c%bb%e8%8d%af%e5%92%8c-ambrx-%e7%9a%84-arx788-%e4%b8%b4%e5%ba%8a%e8%af%95%e9%aa%8c%e8%8e%b7%e7%a7%af%e6%9e%81%e6%95%b0%e6%8d%ae\/","title":{"rendered":"\u6d59\u6c5f\u533b\u836f\u548cAmbrx\u7684 ARX788\u4e34\u5e8a\u8bd5\u9a8c\u83b7\u79ef\u6781\u6570\u636e"},"content":{"rendered":"

\u6d59\u6c5f\u533b\u836f\u3001\u6d59\u6c5f\u65b0\u7801\u751f\u7269\u548cAmbrx\u5728\u6b63\u5728\u8fdb\u884c\u7684\u201c 111\u201d\u8bd5\u9a8c\uff08CTR20171162\uff09\u4e2d\u5ba3\u5e03\u4e86\u79ef\u6781\u4e2d\u671f\u6570\u636e\uff0c\u8be5\u8bd5\u9a8c\u8bc4\u4f30\u4e86\u5728\u8f6c\u79fb\u6027HER2\u9633\u6027\u4e73\u817a\u764c\u7684\u5927\u91cf\u9884\u5904\u7406\u60a3\u8005\u4e2d\u4f7f\u7528\u65b0\u578b\u6297HER2 ADC ARX788\u7684\u7597\u6548\u3002\u5165\u7ec4\u7684\u6240\u6709\u60a3\u8005\u5148\u524d\u63a5\u53d7\u66f2\u59a5\u73e0\u5355\u6297\u6cbb\u7597\u5931\u8d25\uff0c47%\u63a5\u53d7\u66f2\u59a5\u73e0\u5355\u6297\u548c\u62c9\u5e15\u66ff\u5c3c\u6cbb\u7597\u5931\u8d25\u3002<\/p>\n

\u5728\u6240\u6709\u5242\u91cf\u6c34\u5e73\u4e0b\uff0cARX788\u5747\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u572851\u540d\u5165\u7ec4\u60a3\u8005\u4e2d\u4ec5\u89c2\u5bdf\u5230\u4e24\u4e2a\u22653\u7ea7\u836f\u7269\u76f8\u5173\u7684\u53ef\u9006\u6027\u4e0d\u826f\u4e8b\u4ef6\u3002ARX788\u5728\u5242\u91cf\u4e0d\u65ad\u589e\u52a0\u65f6\u4f9d\u7136\u5177\u6709\u51fa\u8272\u7684\u5b89\u5168\u6027\u3002<\/p>\n

\u53cd\u5e94\u7387\u4e0e\u5242\u91cf\u6c34\u5e73\u589e\u52a0\u76f8\u5173\u3002\u622a\u81f3\u622a\u6b62\u65e5\u671f\uff0c\u6240\u6d4b\u8bd5\u7684\u6700\u9ad8\u5242\u91cf\u4e3a\u6bcf\u4e09\u54681.5\u6beb\u514b\/\u5343\u514b\u3002\u8be5\u4eba\u7fa4\u7ee7\u7eed\u7ed9\u836f\u5e76\u4e00\u76f4\u5904\u4e8e\u89c2\u5bdf\u4e4b\u4e2d\uff0c\u5df2\u7ecf\u8fbe\u5230\u4e8663%\u7684\u603b\u4f53\u7f13\u89e3\u7387\u3002\u5148\u524d\u7684\u961f\u5217\u7814\u7a76\u5206\u522b\u4e3a0.88\u30011.1\u548c1.3 \u6beb\u514b\/\u5343\u514b\u5242\u91cf\uff0c\u603b\u4f53\u7f13\u89e3\u7387\u5206\u522b\u4e3a14%\uff0c36%\u548c56%\u3002\u6b64\u5916\uff0c\u4ec5\u5728\u8f7b\u5ea6\u589e\u52a0\u6bd2\u6027\u7684\u60c5\u51b5\u4e0b\uff0c\u5c31\u53ef\u4ee5\u5728\u8f83\u9ad8\u5242\u91cf\u4e0b\u89c2\u5bdf\u5230\u7597\u6548\u7684\u5b9e\u8d28\u6027\u63d0\u9ad8\u3002<\/p>\n

\u8fd9\u4e9b\u6570\u636e\u6765\u81ea\u4e2d\u56fd\u590d\u65e6\u5927\u5b66\u4e0a\u6d77\u764c\u75c7\u4e2d\u5fc3\uff0c\u8fd9\u662f\u66f4\u5e7f\u6cdb\u7684\u5168\u7403ARX788\u5f00\u53d1\u8ba1\u5212\uff08NCT03255070\u548cCTR20171162\uff09\u7684\u4e00\u90e8\u5206\uff0c\u8be5\u8ba1\u5212\u5305\u62ec\u5728\u4e2d\u56fd\u3001\u7f8e\u56fd\u548c\u6fb3\u5927\u5229\u4e9a\u7684\u4e34\u5e8a\u8bd5\u9a8c\u70b9\u3002<\/p>\n

\u6d59\u6c5f\u533b\u836f\u4e8e2013\u5e74\u5728\u4e2d\u56fd\u83b7\u5f97\u4e86ARX788\u7684\u5546\u4e1a\u6388\u6743\u3002ARX788\u4ee4\u4eba\u9f13\u821e\u7684\u4e34\u5e8a\u6570\u636e\u4e3a\u7b2c\u4e8c\u6b21\u53ca\u4ee5\u540e\u7684\u5408\u4f5c\u5960\u5b9a\u4e86\u575a\u5b9e\u7684\u57fa\u7840\u3002\u4eca\u5e74\u65e9\u4e9b\u65f6\u5019\uff0cAmbrx\u548c\u6d59\u6c5f\u533b\u836f\uff08\u901a\u8fc7\u5176\u5b50\u516c\u53f8\u6d59\u6c5f\u65b0\u7801\u751f\u7269\uff09\u5f00\u59cb\u4e86\u7b2c\u4e8c\u6b21\u5408\u4f5c\uff0c\u4ee5\u5728\u4e2d\u56fd\u5f00\u53d1\u548c\u5546\u4e1a\u5316ARX305\u3002 ARX305\u662f\u4e00\u79cd\u6297CD70\u6297\u4f53\u836f\u7269\u5076\u8054\u7269\uff0c\u7528\u4e8e\u6f5c\u5728\u6cbb\u7597\u80be\u7ec6\u80de\u764c\u3001\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u548c\u5176\u4ed6\u5b9e\u4f53\u7624\u3002<\/p>\n

Ambrx Inc.\u662f\u4e00\u5bb6\u4e34\u5e8a\u9636\u6bb5\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4f7f\u7528\u6269\u5c55\u7684\u9057\u4f20\u5bc6\u7801\u521b\u5efa\u540c\u7c7b\u6700\u4f73\u7684\u751f\u7269\u7597\u6cd5\uff0c\u5305\u62ec\u6297\u4f53\u836f\u7269\u5076\u8054\u7269\uff08ADC\uff09\u3001\u9776\u5411\u514d\u75ab\u8c03\u8282\u5242\u3001\u53cc\u7279\u5f02\u6027\u6297\u4f53\u548c\u5176\u4ed6\u5177\u6709\u6539\u5584\u7684\u836f\u7406\u7279\u6027\u6216\u751f\u7269\u6d3b\u6027\u7684\u65b0\u578b\u751f\u7269\u5236\u5242\u3002\u5229\u7528Ambrx\u4e13\u6709\u6280\u672f\u5e73\u53f0\uff0cAmbrx\u4e0e\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u516c\u53f8\u7b49\u5927\u578b\u4f01\u4e1a\u5408\u4f5c\u3002\u5728\u4e0d\u540c\u7684\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\u4f7f\u7528Ambrx\u6280\u672f\u751f\u4ea7\u836f\u54c1\u3002Ambrx\u6b63\u5728\u63a8\u8fdb\u5f3a\u5927\u7684\u5019\u9009\u4ea7\u54c1\u7ec4\u5408\uff0c\u8fd9\u4e9b\u5019\u9009\u4ea7\u54c1\u9488\u5bf9\u591a\u4e2a\u6cbb\u7597\u9886\u57df\u7684\u529f\u6548\u3001\u5b89\u5168\u6027\u548c\u6613\u7528\u6027\u8fdb\u884c\u4e86\u4f18\u5316\u3002\u6709\u5173\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95eehttp:\/\/www.ambrx.com<\/a><\/p>\n

\u6d59\u6c5f\u533b\u836f\u80a1\u4efd\u6709\u9650\u516c\u53f8\uff08ZMC\uff09\u662f\u4e00\u5bb6\u5728\u4e0a\u6d77\u8bc1\u5238\u4ea4\u6613\u6240\uff08SSE\uff03\uff1a600216\uff09\u4e0a\u5e02\u7684\u4e2d\u56fd\u5236\u836f\u516c\u53f8\uff0c\u662f\u8102\u6eb6\u6027\u7ef4\u751f\u7d20\u548c\u6297\u751f\u7d20\u7684\u5168\u7403\u9886\u5148\u5236\u9020\u5546\uff0c\u76ee\u524d\u62e5\u67099\u4e2a\u5b50\u516c\u53f8\u548c2\u4e2a\u7814\u53d1\u90e8\u95e8\u3002\u6709\u5173\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95eehttp:\/\/www.china-zmc.com<\/a><\/p>\n

\u82f1\u6587\u6765\u6e90\uff1aBiospace<\/p>\n","protected":false},"excerpt":{"rendered":"

Zhejiang Medicine, NovoCodex and Ambrx announced positive interim topline data from the ongoing “111” trial (CTR20171162) evaluating ARX788, a novel anti-HER2 ADC, in heavily pretreated patients with metastatic HER2 positive breast cancer.<\/p>\n","protected":false},"author":9,"featured_media":309560,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[427],"tags":[455,925,459],"class_list":["post-309564","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-market-news-zh-hans","tag-455","tag-925","tag-459","sectors-life-science-zh-hans","locations-china-zh-hans","locations-us-zh-hans"],"acf":[],"_links":{"self":[{"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/posts\/309564","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/comments?post=309564"}],"version-history":[{"count":0,"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/posts\/309564\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/media\/309560"}],"wp:attachment":[{"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/media?parent=309564"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/categories?post=309564"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/tags?post=309564"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}