{"id":310187,"date":"2019-12-17T21:46:04","date_gmt":"2019-12-18T05:46:04","guid":{"rendered":"https:\/\/nai500.com\/blog\/2019\/12\/transthera\/"},"modified":"2019-12-17T21:46:20","modified_gmt":"2019-12-18T05:46:20","slug":"%e8%8d%af%e6%8d%b7%e5%ae%89%e5%ba%b7%e8%8e%b7fda%e6%89%b9%e5%87%86%ef%bc%8c%e5%bc%80%e5%90%af%e5%85%a8%e7%90%83%e4%b8%b4%e5%ba%8a%e8%af%95%e9%aa%8c","status":"publish","type":"post","link":"https:\/\/nai500.com\/zh-hans\/blog\/2019\/12\/%e8%8d%af%e6%8d%b7%e5%ae%89%e5%ba%b7%e8%8e%b7fda%e6%89%b9%e5%87%86%ef%bc%8c%e5%bc%80%e5%90%af%e5%85%a8%e7%90%83%e4%b8%b4%e5%ba%8a%e8%af%95%e9%aa%8c\/","title":{"rendered":"\u836f\u6377\u5b89\u5eb7\u83b7FDA\u6279\u51c6\uff0c\u5f00\u542f\u5168\u7403\u4e34\u5e8a\u8bd5\u9a8c"},"content":{"rendered":"<p>\u5357\u4eac\u836f\u6377\u5b89\u5eb7\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\u5ba3\u5e03\uff0c\u516c\u53f8\u81ea\u4e3b\u7814\u53d1\u7684\u9488\u5bf9\u6162\u6027\u5fc3\u529b\u8870\u7aed\u7684\u65b0\u578b\u5c0f\u5206\u5b50\u836f\u7269TT-00920\u83b7\u5f97\u7f8e\u56fdFDA IND\u4e34\u5e8a\u8bd5\u9a8c\u6279\u51c6\u3002TT-00920\u662f\u4e00\u79cd\u65b0\u578b\u7684\u78f7\u9178\u4e8c\u916f\u91769\uff08PDE 9\uff09\u5c0f\u5206\u5b50\u6291\u5236\u5242\uff0c\u7528\u4e8e\u6cbb\u7597\u6162\u6027\u5fc3\u529b\u8870\u7aed\u3002\u836f\u6377\u5b89\u5eb7\u5c06\u542f\u52a81\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4ee5\u8bc4\u4f30TT-00920\u5728\u5065\u5eb7\u5fd7\u613f\u8005\u4e2d\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001\u836f\u4ee3\u52a8\u529b\u5b66\u548c\u836f\u6548\u5b66\u3002\u8be5\u8bd5\u9a8c\u9884\u8ba1\u4e8e2020\u5e74\u521d\u5f00\u59cb\u3002<\/p>\n<p>\u836f\u6377\u5b89\u5eb7\u521b\u59cb\u4eba\u517c\u9996\u5e2d\u6267\u884c\u5b98Frank Wu\u535a\u58eb\u8868\u793a\uff1a\u201c IND\u6279\u51c6TT-00920\u662f\u836f\u6377\u5b89\u5eb7\u7684\u91cd\u8981\u91cc\u7a0b\u7891\u3002\u6211\u4eec\u76f8\u4fe1\uff0cTT-00920\u6709\u671b\u6210\u4e3a\u60a3\u6709\u6162\u6027\u5fc3\u529b\u8870\u7aed\uff0c\u5c24\u5176\u662fHFpEF\uff08\u5c04\u8840\u5206\u6570\u6301\u7eed\u5347\u9ad8\u7684\u5fc3\u529b\u8870\u7aed\uff09\u7684\u6162\u6027\u60a3\u8005\u7684\u65b0\u7684\u8f6c\u5316\u6cbb\u7597\u9009\u62e9\uff0cHFpEF\u662f\u5fc3\u529b\u8870\u7aed\u7684\u4e3b\u8981\u5f62\u5f0f\uff0c\u6ca1\u6709\u53ef\u4ee5\u6539\u53d8\u75be\u75c5\u7684\u6cbb\u7597\u9009\u62e9\u3002\u6211\u4eec\u671f\u5f85\u4e0e\u60a3\u8005\u548c\u533b\u751f\u5408\u4f5c\uff0c\u8bc4\u4f30TT-00920\u5728\u4e34\u5e8a\u4e2d\u7684\u6f5c\u529b\u3002\u201d<\/p>\n<p>TT-00920\u662f\u4e00\u79cd\u7528\u4e8e\u7814\u7a76\u6162\u6027\u5fc3\u529b\u8870\u7aed\u7684\u7814\u7a76\u6027\uff0c\u9ad8\u6548\u548c\u9009\u62e9\u6027PDE9\u6291\u5236\u5242\u3002PDE9\u86cb\u767d\u5e72\u6270\u4eba\u4f53\u4e2d\u548c\u5fc3\u810f\u538b\u529b\u6240\u5fc5\u9700\u7684\u5929\u7136\u201c\u5236\u52a8\u201d\u7cfb\u7edf\uff0c\u5e76\u4e14\u5728\u5fc3\u529b\u8870\u7aed\uff08\u7279\u522b\u662fHFpEF\u4e2d\uff09\u65b9\u9762\u8868\u73b0\u51fa\u660e\u663e\u7684\u5347\u9ad8\u3002\u7528TT-00920\u6291\u5236PDE9\u53ef\u6062\u590d\u5fc3\u810f\u8870\u7aed\u65f6\u529f\u80fd\u5931\u8c03\u7684\u5fc3\u810f\u4fdd\u62a4\u673a\u5236\u3002\u4ee4\u4eba\u4fe1\u670d\u7684\u4e34\u5e8a\u524d\u6570\u636e\u8868\u660e\uff0cTT-00920\u5728\u5fc3\u529b\u8870\u7aed\u4e2d\u53ef\u663e\u8457\u589e\u5f3a\u5fc3\u810f\u529f\u80fd\u5e76\u9006\u8f6c\u5fc3\u5ba4\u91cd\u6784\u3002<\/p>\n<p>\u836f\u6377\u5b89\u5eb7\u6210\u7acb\u4e8e2016\u5e74\uff0c\u662f\u4e00\u5bb6\u4e34\u5e8a\u9636\u6bb5\u7684\u751f\u7269\u6280\u672f\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u5f00\u53d1\u521b\u65b0\u7597\u6cd5\uff0c\u4ee5\u6cbb\u7597\u5305\u62ec\u764c\u75c7\u3001\u5fc3\u8840\u7ba1\u75be\u75c5\u548c\u708e\u6027\u75be\u75c5\u7b49\u4e3b\u8981\u672a\u6ee1\u8db3\u533b\u7597\u9700\u6c42\u7684\u75be\u75c5\u3002TT-00920\u662f\u8be5\u516c\u53f8\u8fdb\u5165\u5168\u7403\u4e34\u5e8a\u5f00\u53d1\u7684\u7b2c\u4e8c\u4e2a\u521b\u65b0\u5019\u9009\u836f\u7269\u3002<\/p>\n<p>\u82f1\u6587\u6765\u6e90\uff1aBiospace<\/p>\n","protected":false},"excerpt":{"rendered":"<p>TransThera Biosciences Co. 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