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mRNA-1273\u662f\u4e00\u79cd\u9488\u5bf9\u65b0\u51a0\u75c5\u6bd2\u7f16\u7801\u7684Spike (S)\u86cb\u767d\u9884\u878d\u5408\u7a33\u5b9a\u5f62\u5f0f\u7684mRNA\u75ab\u82d7\uff0c\u7531Moderna\u7814\u7a76\u4eba\u5458\u4e0eNIAID\u75ab\u82d7\u7814\u7a76\u4e2d\u5fc3\uff08VRC\uff09\u7684\u79d1\u5b66\u5bb6\u5408\u4f5c\u9009\u62e9\u3002\u6279\u751f\u4ea7\u7684\u8d44\u91d1\u6765\u81ea\u6d41\u884c\u75c5\u9632\u8303\u521b\u65b0\u8054\u76df\uff08\uff08CEPI\uff09\u3002<\/p>\n
\u8be5\u8bd5\u9a8c\u6b63\u5728\u897f\u96c5\u56fe\u7684Kaiser Permanente\u534e\u76db\u987f\u5065\u5eb7\u7814\u7a76\u6240\u8fdb\u884c\u3002\u4eca\u5929\u6709\u7b2c\u4e00\u4f8b\u75c5\u4eba\u3002\u8be5\u8bd5\u9a8c\u5c06\u63a5\u79cd\u5305\u62ec45\u540d\u5e74\u8f7b\u5065\u5eb7\u7684\u5fd7\u613f\u8005\uff0c\u4ed6\u4eec\u5c06\u63a5\u53d7\u4e0d\u540c\u5242\u91cf\u7684\u75ab\u82d7\u3002\u56e0\u4e3a\u75ab\u82d7\u4e0d\u5305\u542b\u5b9e\u9645\u7684\u65b0\u51a0\u75c5\u6bd2\uff0c\u6240\u4ee5\u53c2\u52a0\u8005\u4e0d\u53ef\u80fd\u88ab\u75ab\u82d7\u611f\u67d3\u3002\u8be5\u6d4b\u8bd5\u7684\u76ee\u7684\u662f\u8bc4\u4f30\u4efb\u4f55\u5b89\u5168\u6027\u95ee\u9898\uff0c\u5e76\u786e\u5b9a\u9002\u5f53\u7684\u5242\u91cf\u4ee5\u523a\u6fc0\u6709\u6548\u7684\u514d\u75ab\u53cd\u5e94\u3002<\/p>\n
\u4e16\u754c\u4e0a\u8bb8\u591a\u5176\u4ed6\u516c\u53f8\u548c\u673a\u6784\u4e5f\u5728\u52aa\u529b\u5f00\u53d1\u9488\u5bf9\u65b0\u51a0\u75c5\u6bd2\u7684\u75ab\u82d7\uff0c\u5176\u4e2d\u5305\u62ecInovio Pharmaceuticals\uff0c\u8be5\u516c\u53f8\u9884\u8ba1\u4e0b\u4e2a\u6708\u5c06\u5728\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5927\u5b66\u548c\u5bc6\u82cf\u91cc\u5dde\u582a\u8428\u65af\u5e02\u7684\u6d4b\u8bd5\u4e2d\u5fc3\u5f00\u59cb\u8bd5\u9a8c\u3002<\/p>\n
\u518d\u751f\u5143\u548c\u8d5b\u8bfa\u83f2\uff08Sanofi\uff09\u5df2\u5728\u91cd\u75c7\u4f4f\u9662\u65b0\u51a0\u80ba\u708e\u60a3\u8005\u4e2d\u542f\u52a8\u4e86Kevzara\uff08sarilumab\uff09\u7684\u7f8e\u56fd\u4e34\u5e8a\u8bd5\u9a8c\u3002\u5b83\u5c06\u5728\u7f8e\u56fd\u7ea616\u4e2a\u5730\u70b9\u6d4b\u8bd5400\u540d\u60a3\u8005\u3002<\/p>\n
\u5409\u5229\u5fb7\u79d1\u5b66\u516c\u53f8\uff08Gilead Sciences\uff09\u5ba3\u5e03\u5c06\u9488\u5bf9\u8bca\u65ad\u60a3\u6709\u65b0\u51a0\u75c5\u6bd2\u7684\u6210\u5e74\u4eba\u5f00\u5c55\u6297\u75c5\u6bd2\u836f\u7269\u745e\u5fb7\u6614\u97e6\u7684\u4e24\u9879III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n
\u8fd9\u4e9b\u516c\u53f8\u901a\u5e38\u81f4\u529b\u4e8e\u4f7f\u7528\u4e0d\u540c\u7684\u65b9\u6cd5\u6765\u5f00\u53d1\u75ab\u82d7\uff0c\u8fd9\u5c06\u5177\u6709\u4e0d\u540c\u7684\u751f\u4ea7\u65f6\u95f4\u8868\u548c\u4e0d\u540c\u7684\u6548\u529b\u6c34\u5e73\u3002\u636e\u300a\u8d22\u5bcc\u300b\u6742\u5fd7\u62a5\u9053\uff0c\u4e00\u4e9b\u7814\u7a76\u4eba\u5458\u6b63\u5728\u7814\u7a76\u4e34\u65f6\u75ab\u82d7\uff0c\u8fd9\u4e9b\u4e34\u65f6\u75ab\u82d7\u53ef\u80fd\u4f1a\u5728\u5f00\u53d1\u66f4\u6301\u4e45\u7684\u75ab\u82d7\u65f6\u63d0\u4f9b\u6570\u6708\u7684\u4fdd\u62a4\u3002<\/p>\n
Moderna mRNA\u65b9\u6cd5\u7684\u4e00\u9879\u4f18\u52bf\u662f\u5176\u5f00\u53d1\u901f\u5ea6\u3002\u8be5\u75c5\u6bd2\u57281\u67087\u65e5\u548c1\u670813\u65e5\u83b7\u5f97\u9274\u5b9a\uff0c\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\u548cModerna\u7814\u7a76\u4eba\u5458\u5df2\u7ecf\u63d0\u51fa\u4e86\u8be5\u75ab\u82d7\u7684mRNA\u5e8f\u5217\uff0c\u5e76\u5728\u653f\u5e9c\u6587\u4ef6\u4e2d\u5199\u9053\uff1a\u201c\u6211\u4eec\u5df2\u52a8\u5458\u8d77\u6765\u8fdb\u884c\u4e34\u5e8a\u751f\u4ea7\u3002\u201d2\u670824\u65e5\u81f325\u65e5\uff0c\u4ed6\u4eec\u5c06\u75ab\u82d7\u4ece\u9a6c\u8428\u8bf8\u585e\u5dde\u8bfa\u4f0d\u5fb7\u5e02\u7684\u5236\u9020\u5de5\u5382\u8fd0\u9001\u5230\u9a6c\u91cc\u5170\u5dde\u7684NIAID\u3002<\/p>\n
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