{"id":357564,"date":"2020-11-13T18:33:46","date_gmt":"2020-11-14T02:33:46","guid":{"rendered":"https:\/\/nai500.com\/blog\/2020\/11\/apollomics-inc-receives-china-investigational-new-drug-approval-for-apl-102-to-initiate-a-phase-1-study\/"},"modified":"2020-11-13T18:34:55","modified_gmt":"2020-11-14T02:34:55","slug":"%e4%b8%ad%e7%be%8e%e8%8d%af%e4%bc%81%e5%86%a0%e7%a7%91%e7%be%8e%e5%8d%9a-apl-102-%e4%b8%80%e6%9c%9f%e4%b8%b4%e5%ba%8a%e8%af%95%e9%aa%8c%e8%8e%b7%e6%89%b9","status":"publish","type":"post","link":"https:\/\/nai500.com\/zh-hans\/blog\/2020\/11\/%e4%b8%ad%e7%be%8e%e8%8d%af%e4%bc%81%e5%86%a0%e7%a7%91%e7%be%8e%e5%8d%9a-apl-102-%e4%b8%80%e6%9c%9f%e4%b8%b4%e5%ba%8a%e8%af%95%e9%aa%8c%e8%8e%b7%e6%89%b9\/","title":{"rendered":"\u4e2d\u7f8e\u836f\u4f01\u51a0\u79d1\u7f8e\u535aAPL-102\u4e00\u671f\u4e34\u5e8a\u8bd5\u9a8c\u83b7\u6279"},"content":{"rendered":"<p>\u51a0\u79d1\u7f8e\u535a\uff08Apollomics, Inc.\uff09\u662f\u4e00\u5bb6\u521b\u65b0\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u53d1\u73b0\u548c\u5f00\u53d1\u65b0\u578b\u80bf\u7624\u9776\u5411\u5242\u548c\u514d\u75ab\u80bf\u7624\u5242\u53ca\u5176\u7ec4\u5408\u7597\u6cd5\uff0c\u5ba3\u5e03APL-102\u83b7\u5f97\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE\uff09\u6838\u51c6\u7b7e\u53d1\u7684\u300a\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u6279\u51c6\u901a\u77e5\u4e66\u300b\uff0c\u6279\u51c6\u542f\u52a8APL-102 I\u671f\u5728\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\u8fdb\u884c\u836f\u4ee3\u52a8\u529b\u5b66\uff08PK\uff09\u548c\u8010\u53d7\u6027\u7814\u7a76\u3002<\/p>\n<p>\u51a0\u79d1\u7f8e\u535a\u516c\u53f8\u8054\u5408\u521b\u59cb\u4eba\u3001\u8463\u4e8b\u957f\u517c\u9996\u5e2d\u6267\u884c\u5b98\u4f59\u56fd\u826f\u535a\u58eb\u8868\u793a \uff1a\u201cAPL-102\u662f\u6211\u4eec\u81ea\u4e3b\u7814\u53d1\u7684\u4e00\u4e2a\u5c0f\u5206\u5b50\u591a\u6fc0\u9176\u6291\u5236\u5242\u3002\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\uff0c\u5b83\u5728\u809d\u764c\u3001\u4e73\u817a\u764c\u3001\u7ed3\u80a0\u76f4\u80a0\u764c\u3001\u80c3\u764c\u3001\u98df\u9053\u764c\u548c\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u60a3\u8005\u6765\u6e90\u7684\u80bf\u7624\u79fb\u690d\u5c0f\u9f20\u6a21\u578b\uff08PDX\uff09\u4e2d\u8868\u73b0\u51fa\u5e7f\u6cdb\u5e76\u4e14\u5f88\u5f3a\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u5177\u6709\u4f18\u5f02\u7684\u53e3\u670d\u751f\u7269\u5229\u7528\u5ea6\uff0c\u4e14\u6bd2\u6027\u8f83\u4f4e\u3002APL-102\u4e0d\u4ec5\u6709\u53ef\u80fd\u4f5c\u4e3a\u5355\u4e00\u836f\u7269\u6cbb\u7597\u60a3\u8005\uff0c\u4e5f\u5177\u6709\u548c\u514d\u75ab\u6cbb\u7597\u7b49\u8fdb\u884c\u8054\u5408\u6cbb\u7597\u7684\u5de8\u5927\u6f5c\u529b\u3002<\/p>\n<p><strong>\u5173\u4e8eAPL-102<\/strong><\/p>\n<p>\u51a0\u79d1\u7f8e\u535aAPL-102\u662f\u9488\u5bf9\u591a\u79cd\u5173\u952e\u81f4\u764c\u9a71\u52a8\u56e0\u5b50\u7684\u53e3\u670d\u591a\u6fc0\u9176\u6291\u5236\u5242\uff08mKi\uff09\u3002 APL-102\u6291\u5236\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\uff08RTKs\uff09\u548c\u4e1d\u6c28\u9178\/\u82cf\u6c28\u9178\u6fc0\u9176\uff0c\u5305\u62ec\uff1a\u8840\u7ba1\u751f\u6210\uff0c\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08VEGFR\uff09\u548c\u8840\u5c0f\u677f\u884d\u751f\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08PDGFR\uff09\uff1b\u4e1d\u88c2\u539f\u6d3b\u5316\u86cb\u767d\u6fc0\u9176\uff08MAPK\uff09\u9014\u5f84\uff0cB-RAF\u548cC-RAF\uff1bRET\uff0cCSF1R\uff0cDDR1\u548cc-KIT\u3002Apollomics\u62e5\u6709APL-102\u7684\u5168\u7403\u4e34\u5e8a\u5f00\u53d1\uff0c\u751f\u4ea7\u548c\u5546\u4e1a\u9500\u552e\u6743\u3002<\/p>\n<p>\u82f1\u6587\u6765\u6e90\uff1aBiospace<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u51a0\u79d1\u7f8e\u535a\uff08Apollomics, Inc.\uff09\u662f\u4e00\u5bb6\u521b\u65b0\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u53d1\u73b0\u548c\u5f00\u53d1\u65b0\u578b\u80bf\u7624\u9776\u5411\u5242\u548c\u514d\u75ab\u80bf\u7624 [&hellip;]<\/p>\n","protected":false},"author":9,"featured_media":357561,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[427],"tags":[455,925,459],"class_list":["post-357564","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-market-news-zh-hans","tag-455","tag-925","tag-459","sectors-life-science-zh-hans","locations-china-zh-hans","locations-us-zh-hans"],"acf":[],"_links":{"self":[{"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/posts\/357564","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/comments?post=357564"}],"version-history":[{"count":0,"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/posts\/357564\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/media\/357561"}],"wp:attachment":[{"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/media?parent=357564"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/categories?post=357564"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/tags?post=357564"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}