{"id":442412,"date":"2022-11-03T23:46:16","date_gmt":"2022-11-04T06:46:16","guid":{"rendered":"https:\/\/nai500.com\/?p=442412"},"modified":"2022-11-03T23:46:16","modified_gmt":"2022-11-04T06:46:16","slug":"%e5%86%85%e9%83%a8%e4%ba%ba-%e4%b9%b0%e8%b7%8c-%e4%b8%a4%e5%8f%aa-%e7%be%8e%e5%9b%bd%e7%94%9f%e7%89%a9%e7%a7%91%e6%8a%80%e8%82%a1%e7%a5%a8-%e8%a7%81%e5%ba%95","status":"publish","type":"post","link":"https:\/\/nai500.com\/zh-hans\/blog\/2022\/11\/%e5%86%85%e9%83%a8%e4%ba%ba-%e4%b9%b0%e8%b7%8c-%e4%b8%a4%e5%8f%aa-%e7%be%8e%e5%9b%bd%e7%94%9f%e7%89%a9%e7%a7%91%e6%8a%80%e8%82%a1%e7%a5%a8-%e8%a7%81%e5%ba%95\/","title":{"rendered":"\u5185\u90e8\u4eba\u90fd\u5728\u4e70\u8dcc\uff0c\u8fd9\u4e24\u53ea\u7f8e\u56fd\u751f\u7269\u79d1\u6280\u80a1\u7968\u53ef\u80fd\u5373\u5c06\u89c1\u5e95"},"content":{"rendered":"

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\u8fd9\u4e9b\u9ad8\u7ba1\u548c\u8463\u4e8b\u7b49\u5185\u90e8\u4eba\u6700\u4e86\u89e3\u516c\u53f8\u7684\u7ecf\u8425\u60c5\u51b5\u3002\u5982\u679c\u4ed6\u4eec\u613f\u610f\u81ea\u638f\u8170\u5305\u4e70\u5165\u516c\u53f8\u80a1\u7968\uff0c\u81f3\u5c11\u8bf4\u660e\u4ed6\u4eec\u8ba4\u4e3a\u80a1\u7968\u88ab\u4f4e\u4f30\u4e86\u3002\u4e0b\u9762\u8fd9\u4e24\u53ea\u7f8e\u56fd\u751f\u7269\u79d1\u6280\u80a1\u7968\u7684\u80a1\u4ef7\u4eca\u5e74\u5927\u5e45\u4e0b\u8dcc\uff0c\u6700\u8fd1\u5185\u90e8\u4eba\u5f00\u59cb\u9022\u4f4e\u4e70\u5165\u8fd9\u4e9b\u80a1\u7968\uff0c\u8fd9\u53ef\u80fd\u9884\u793a\u7740\u80a1\u4ef7\u5373\u5c06\u89c1\u5e95\u3002<\/p>\n

Insmed Inc\uff08NASDAQ:INSM\uff09<\/a><\/h2>\n

2018\u5e74\uff0c\u4e13\u6ce8\u4e8e\u7f55\u89c1\u75c5\u836f\u7269\u5f00\u53d1\u7684\u751f\u7269\u79d1\u6280\u516c\u53f8Insmed\u7684\u6297\u83cc\u836fArikayce\u2014\u2014\u9002\u5e94\u75c7\u4e3a\u9e1f\u80de\u5185\u5206\u679d\u6746\u83cc\u590d\u5408\u4f53\uff08MAC\uff09\u611f\u67d3\u5f15\u53d1\u7684\u96be\u6cbb\u6027\u975e\u7ed3\u6838\u5206\u679d\u6746\u83cc\uff08NTM\uff09\u80ba\u75c5\u2014\u2014\u83b7\u5f97\u6279\u51c6\uff0c\u56e0\u6b64\u83b7\u5f97\u4e86\u7a33\u5b9a\u7684\u6536\u5165\u6765\u6e90\u3002\u6700\u65b0\u53d1\u5e03\u7684\u4e09\u5b63\u62a5\u663e\u793a\uff0cArikayce\u7684\u9500\u552e\u989d\u540c\u6bd4\u589e\u957f45%\u81f3$6770\u4e07\uff0c\u6709\u671b\u5b9e\u73b0\u516c\u53f82022\u5e74\u9500\u552e\u989d\u81f3\u5c11\u589e\u957f30%\u7684\u76ee\u6807\u3002<\/p>\n

\u9664\u4e86\u5df2\u7ecf\u4e0a\u5e02\u7684\u836f\uff0cInsmed\u7684\u5728\u7814\u836f\u7269\u5305\u62ec\u652f\u6c14\u7ba1\u6269\u5f20\u836f\u7269brensocatib\uff0c\u4e09\u671fASPEN\u7814\u7a76\u7684\u62db\u52df\u5de5\u4f5c\u9884\u8ba1\u5c06\u4e8e1Q23\u5b8c\u6210\uff0c\u8bd5\u9a8c\u6570\u636e2Q24\u51fa\u7089\u3002\u6b64\u5916\uff0cbrensocatib\u6cbb\u7597\u56ca\u6027\u7ea4\u7ef4\u5316\uff08CF\uff09\u60a3\u8005\u7684\u4e8c\u671f\u836f\u4ee3\u52a8\u529b\u5b66\/\u836f\u6548\u5b66\u8bd5\u9a8c\u4e5f\u5728\u8fdb\u884c\u4e2d\uff0c\u6570\u636e\u9884\u8ba1\u5c06\u57282022\u5e74\u5e95\u53d1\u5e03\u3002TPIP\u5438\u5165\u5242\u7684\u4e24\u9879\u4e8c\u671f\u7814\u7a76\u6b63\u5728\u62db\u52df\u88ab\u8bd5\uff0c\u6570\u636e\u9884\u8ba1\u5c06\u57282023\u5e74\u53d1\u5e03\u3002\u6700\u540e\uff0cArikayce\u7684\u4e0a\u5e02\u540e\u786e\u8bc1\u6027\u4e34\u5e8a\u8bd5\u9a8c\uff08ARISE\u548cENCORE\u8bd5\u9a8c\uff09\u6b63\u5728\u8fdb\u884c\u4e2d\u3002<\/p>\n

\u5c3d\u7ba1\u5982\u6b64\uff0cINSM\u80a1\u4ef7\u4eca\u5e74\u4e0b\u8dcc34%\u3002\u597d\u6d88\u606f\u662f\uff0c\u672c\u5468\u4e24\u4f4d\u5185\u90e8\u4eba\u8ba4\u4e3a\u4e70\u5165\u65f6\u673a\u5230\u4e86\uff0c\u5176\u4e2d\u8463\u4e8bMelvin Sharoky\u4e70\u51653\u4e07\u80a1\uff0c\u4ef7\u503c$527700\u7684\u80a1\u7968\uff0c\u53e6\u5916\u8463\u4e8bLeo Lee\u4e70\u51654.5\u4e07\u80a1\uff0c\u4ef7\u503c$791550\u7684\u80a1\u7968\u3002<\/p>\n

Taysha Gene Therapies Inc\uff08NASDAQ:TSHA\uff09<\/a><\/h2>\n

\u53e6\u4e00\u53ea\u7f8e\u56fd\u751f\u7269\u79d1\u6280\u516c\u53f8Taysha Gene Therapies\u65e8\u5728\u5f00\u53d1\u591a\u79cd\u6cbb\u7597\u5355\u57fa\u56e0\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u7684\u57fa\u56e0\u7597\u6cd5\u5e76\u4e0a\u5e02\u3002<\/p>\n

Taysha\u7684\u817a\u76f8\u5173\u75c5\u6bd2\uff08AAV\uff09\u57fa\u56e0\u7597\u6cd5\u5728\u7814\u836f\u7269\u5f53\u4e2d\uff0cTSHA-120\u6cbb\u7597\u7684\u662f\u4e00\u79cd\u7f55\u89c1\u7684\u9057\u4f20\u6027\u57fa\u56e0\u75be\u75c5\u2014\u2014\u5de8\u8f74\u7d22\u795e\u7ecf\u75c5\uff08GAN\uff09\uff0c\u5e76\u4e14\u5df2\u7ecf\u83b7\u5f97\u4e86FDA\u7684\u5b64\u513f\u836f\u548c\u7f55\u89c1\u5c0f\u513f\u75be\u75c5\u8d44\u683c\u8ba4\u5b9a\u30021\/2\u671f\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u663e\u793a\uff0c\u63a5\u53d7\u6cbb\u7597\u7684\u60a3\u8005\u91cd\u65b0\u83b7\u5f97\u4e86\u611f\u89c9\u795e\u7ecf\u6ce2\u5e45\uff08SNAPs\uff09\uff0c\u540c\u65f6\u663e\u793a\u4e34\u5e8a\u6539\u5584\u3002\u8be5\u516c\u53f8\u9884\u8ba1\u5c06\u572812\u670813\u65e5\u4e0eFDA\u4f1a\u9762\u3002<\/p>\n

\u6b64\u5916\uff0cTSHA-102\u662f\u7b2c\u4e00\u4e5f\u662f\u552f\u4e00\u6b63\u5728\u5f00\u53d1\u6cbb\u7597\u96f7\u7279\u7efc\u5408\u5f81\u2014\u2014\u4e00\u79cd\u5f71\u54cd\u5927\u8111\u53d1\u80b2\u7684\u7f55\u89c1\u9057\u4f20\u75c5\u2014\u2014\u7684\u57fa\u56e0\u7597\u6cd5\u3002TSHA-102\u5df2\u7ecf\u83b7\u5f97\u5b64\u513f\u836f\u548c\u7f55\u89c1\u5c0f\u513f\u75be\u75c5\u7684\u8d44\u683c\u8ba4\u5b9a\uff0c1\/2\u671f\u7814\u7a76\u7684\u6570\u636e\u9884\u8ba1\u5c06\u4e8e1H23\u51fa\u7089\u3002<\/p>\n

10\u6708\uff0cTaysha\u5ba3\u5e03\u83b7\u5f97\u5b89\u65af\u6cf0\u6765\u5236\u836fAstellas Pharma\uff08JP:4503\uff09$5000\u4e07\u7684\u6218\u7565\u6295\u8d44\uff0c\u83b7\u5f97\u8be5\u516c\u53f8\u5927\u7ea615%\u7684\u80a1\u6743\uff0c\u4ee5\u53caTSHA-102\uff08\u96f7\u7279\u7efc\u5408\u5f81\uff09\u548cTSHA-120\uff08\u5de8\u8f74\u7d22\u795e\u7ecf\u75c5\uff09\u7684\u72ec\u5360\u8bb8\u53ef\u9009\u62e9\u6743\u3002\u6b64\u5916\u5728\u672c\u5468\uff0c\u8463\u4e8bPaul B Manning\u4e70\u5165150\u4e07\u80a1\uff0c\u603b\u989d\u8fbe$300\u4e07\u7684Taysha\u80a1\u7968\u3002\u8be5\u80a1\u80a1\u4ef7\u4eca\u5e74\u8fc4\u4eca\u4e0b\u8dcc83%\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

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