{"id":466676,"date":"2023-07-11T20:06:35","date_gmt":"2023-07-12T03:06:35","guid":{"rendered":"https:\/\/nai500.com\/?p=466676"},"modified":"2024-02-26T13:28:10","modified_gmt":"2024-02-26T21:28:10","slug":"%e5%8c%bb%e7%96%97%e4%b9%9f%e6%9c%89%e6%88%90%e9%95%bf%e8%82%a1-%e8%b7%91%e8%b5%a2%e6%a0%87%e6%99%ae500%e6%8c%87%e6%95%b0","status":"publish","type":"post","link":"https:\/\/nai500.com\/zh-hans\/blog\/2023\/07\/%e5%8c%bb%e7%96%97%e4%b9%9f%e6%9c%89%e6%88%90%e9%95%bf%e8%82%a1-%e8%b7%91%e8%b5%a2%e6%a0%87%e6%99%ae500%e6%8c%87%e6%95%b0\/","title":{"rendered":"\u533b\u7597\u4e5f\u6709\u6210\u957f\u80a1\uff0c\u800c\u4e14\u8dd1\u8d62\u6807\u666e500\u6307\u6570"},"content":{"rendered":"<p>\u53bb\u5e74\uff0c\u7f8e\u56fd\u4e09\u5927\u80a1\u6307\u5747\u8dcc\u5165\u718a\u5e02\uff0c\u4f46\u76ee\u524d\u5df2\u7ecf\u6709\u660e\u663e\u7684\u53cd\u5f39\u3002\u5c31\u62ff\u6807\u666e500\u6307\u6570\u6765\u8bf4\uff0c\u8be5\u6307\u6570\u4eca\u5e74\u4e0a\u6da8\u7ea614%\uff0c\u4e2a\u80a1\u7684\u6da8\u5e45\u5c31\u66f4\u5927\u4e86\u3002\u867d\u71362023\u5e74\u4e0a\u534a\u5e74\u533b\u7597\u677f\u5757\u4e0d\u6da8\u53cd\u8dcc\uff0c\u8868\u73b0\u5728\u7f8e\u80a1\u5404\u5927\u677f\u5757\u5f53\u4e2d\u57ab\u5e95\uff0c\u4f46\u533b\u7597\u80a1\u5f53\u4e2d\u4e5f\u4e0d\u4e4f\u6210\u957f\u80a1\u3002<\/p>\n<p>\u4e0b\u9762\u8fd9\u4e24\u53ea\u533b\u7597\u6210\u957f\u80a1\u4e0d\u4ec5\u9006\u52bf\u4e0a\u6da8\uff0c\u6da8\u5e45\u8fbe\u5230\u4e24\u4f4d\u6570\uff0c\u8dd1\u8d62\u4e86\u6807\u666e500\u6307\u6570\u3002\u800c\u4e14\u5b83\u4eec\u7684\u957f\u671f\u524d\u666f\u5149\u660e\uff0c\u672a\u6765\u8fd8\u6709\u7ee7\u7eed\u4e0a\u6da8\u7684\u7a7a\u95f4\u3002<\/p>\n<h2>\u533b\u7597\u6210\u957f\u80a11\uff1aCRISPR Therapeutics<\/h2>\n<p><a href=\"https:\/\/nai500.com\/zh-hans\/%e8%82%a1%e7%a5%a8%e6%9f%a5%e8%af%a2\/?qm_symbol=CRSP\">CRISPR Therapeutics AG\uff08NASDAQ:CRSP\uff09<\/a>\u6216\u8bb8\u6b63\u5728\u5f00\u542f\u4e00\u4e2a\u5b8f\u5927\u7684\u6210\u957f\u6545\u4e8b\uff1a\u8be5\u516c\u53f8\u4e13\u653bCRISPR\/Cas9\u57fa\u56e0\u7f16\u8f91\u6280\u672f\uff0c\u8fd9\u4e00\u5de5\u5177\u672a\u6765\u5c06\u5728\u57fa\u56e0\u75be\u75c5\u7684\u6cbb\u7597\u4e2d\u626e\u6f14\u4e00\u4e2a\u91cd\u8981\u7684\u89d2\u8272\u3002<\/p>\n<p>\u6700\u8fd1\uff0c\u8be5\u751f\u7269\u79d1\u6280\u516c\u53f8\u548c\u5408\u4f5c\u516c\u53f8\u798f\u6cf0\u5236\u836fVertex Pharmaceuticals\uff08NASDAQ:VRTX\uff09\u5411\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u63d0\u4ea4\u4e86\u57fa\u56e0\u7f16\u8f91\u7597\u6cd5exa-cel\u6cbb\u7597\u9570\u72b6\u7ec6\u80de\u75c5\uff08SCD\uff09\u548c\u03b2\u5730\u4e2d\u6d77\u8d2b\u8840\u7684\u4e0a\u5e02\u7533\u8bf7\uff0c\u5e76\u4e14FDA\u8ba1\u5212\u5206\u522b\u572812\u6708\u548c\u660e\u5e74\u76843\u6708\u5c31\u8fd9\u4e24\u79cd\u9002\u5e94\u75c7\u7684\u5ba1\u6279\u4f5c\u51fa\u51b3\u5b9a\u3002\u5982\u679c\u83b7\u6279\uff0cExa-cel\u5c06\u6210\u4e3a\u8be5\u516c\u53f8\u7684\u9996\u6b3e\u4ea7\u54c1\u3002\u6b64\u5916\uff0cCRISPR\u8fd8\u6709\u5176\u4ed6\u4f9d\u8d56\u4e8e\u57fa\u56e0\u7f16\u8f91\u7684\u5728\u7814\u5019\u9009\u7597\u6cd5\uff0c\u5176\u4e2d\u514d\u75ab\u80bf\u7624\u5019\u9009\u7597\u6cd5CTX-110\u6b63\u5904\u4e8e\u8bd5\u9a8c\u9636\u6bb5\u3002<\/p>\n<p>\u5373\u4f7f\u8003\u8651\u5230\u4eca\u5e74\u8fc4\u4eca\u7684\u6da8\u5e45\uff0cCRISPR\u7684\u80a1\u7968\u4ef7\u683c\u672a\u6765\u8fd8\u6709\u5f88\u5927\u7684\u4e0a\u6da8\u7a7a\u95f4\u3002\u9664\u4e86\u4e0a\u9762\u63d0\u5230\u7684\u57fa\u56e0\u7f16\u8f91\u7597\u6cd5\u672a\u6765\u5c06\u4e3a\u516c\u53f8\u5e26\u6765\u4ea7\u54c1\u6536\u5165\uff0c\u8be5\u516c\u53f8\u8fd8\u53ef\u4ee5\u5c06CRISPR\/Cas9\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u6388\u6743\u7ed9\u5176\u4ed6\u516c\u53f8\u83b7\u5f97\u6536\u5165\u3002\u6bd4\u5982\u8bf4\uff0c\u798f\u6cf0\u5236\u836f\u5df2\u83b7\u5f97\u8be5\u6280\u672f\u6388\u6743\u7528\u4e8e\u5b83\u7684\u4e00\u578b\u7cd6\u5c3f\u75c5\u7814\u53d1\u9879\u76ee\u3002<\/p>\n<h2>\u533b\u7597\u6210\u957f\u80a12. 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