{"id":553225,"date":"2024-10-02T00:22:54","date_gmt":"2024-10-02T07:22:54","guid":{"rendered":"https:\/\/nai500.com\/?p=553225"},"modified":"2024-10-02T15:00:50","modified_gmt":"2024-10-02T22:00:50","slug":"%e7%99%be%e6%97%b6%e7%be%8e%e6%96%bd%e8%b4%b5%e5%ae%9d%e6%94%af%e4%bb%98-1-1-%e4%ba%bf%e7%be%8e%e5%85%83%e8%be%be%e6%88%90-t-%e7%bb%86%e8%83%9e%e7%96%97%e6%b3%95%e5%8d%8f%e8%ae%ae","status":"publish","type":"post","link":"https:\/\/nai500.com\/zh-hans\/blog\/2024\/10\/%e7%99%be%e6%97%b6%e7%be%8e%e6%96%bd%e8%b4%b5%e5%ae%9d%e6%94%af%e4%bb%98-1-1-%e4%ba%bf%e7%be%8e%e5%85%83%e8%be%be%e6%88%90-t-%e7%bb%86%e8%83%9e%e7%96%97%e6%b3%95%e5%8d%8f%e8%ae%ae\/","title":{"rendered":"\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u652f\u4ed81.1\u4ebf\u7f8e\u5143\u8fbe\u6210T\u7ec6\u80de\u7597\u6cd5\u534f\u8bae"},"content":{"rendered":"<p class=\"p1\"><span class=\"s1\">\u6700\u8fd1\uff0c\u533b\u836f\u4f01\u4e1aPrime Medicine \u5411\u6295\u8d44\u8005\u53d1\u51fa\u8b66\u544a\uff0c\u5bf9\u8be5\u516c\u53f8\u662f\u5426\u6709\u80fd\u529b\u7ef4\u6301 12 \u4e2a\u6708\u7684\u8fd0\u8425\u503c\u5f97\u6000\u7591\u3002\u5468\u4e00\u5ba3\u5e03\u7684\u4e24\u7b14\u4ea4\u6613\u5e94\u6709\u52a9\u4e8e\u7f13\u89e3\u5f53\u524d\u7684\u73b0\u91d1\u95ee\u9898\u3002<a href=\"https:\/\/nai500.com\/zh-hans\/%e8%82%a1%e7%a5%a8%e6%9f%a5%e8%af%a2\/?qm_symbol=BMS\">\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\uff08BMS\uff09<\/a>\u5c06\u5411 Prime Medicine \u652f\u4ed8 1.1 \u4ebf\u7f8e\u5143\u7684\u9884\u4ed8\u6b3e\uff0c\u7528\u4e8e\u5f00\u53d1\u4f53\u5916 T \u7ec6\u80de\u7597\u6cd5\u8bd5\u5242\u3002Prime \u5c06\u83b7\u5f97\u9ad8\u8fbe 35 \u4ebf\u7f8e\u5143\u7684\u91cc\u7a0b\u7891\u6536\u76ca\uff0c\u8be5\u516c\u53f8\u5728\u62ab\u9732\u8fd9\u7b14\u4ea4\u6613\u7684\u540c\u65f6\uff0c\u8fd8\u62ab\u9732\u4e86\u65e8\u5728\u5c06\u5176\u73b0\u91d1\u6d41\u5ef6\u957f\u81f3 2026 \u5e74\u4e0a\u534a\u5e74\u7684\u7ba1\u7ebf\u4f18\u5148\u6392\u5e8f\u7ec6\u8282\u3002<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">BMS \u5c06\u4e0e Prime \u5408\u4f5c\uff0c\u8fdb\u4e00\u6b65\u6316\u6398\u7ec6\u80de\u7597\u6cd5\u5728\u514d\u75ab\u5b66\u548c\u80bf\u7624\u5b66\u9886\u57df\u7684\u6f5c\u529b\u3002\u4f5c\u4e3a\u5bf9\u73b0\u91d1\u652f\u4ed8\u548c\u80a1\u6743\u6295\u8d44\u5e73\u5206\u7684\u9884\u4ed8\u6b3e\u7684\u56de\u62a5\uff0cPrime \u5c06\u9488\u5bf9\u9009\u5b9a\u7684\u76ee\u6807\u8bbe\u8ba1\u4f18\u5316\u7684 Prime Editor \u8bd5\u5242\u3002\u8be5\u9879\u76ee\u5305\u62ec\u4f7f\u7528PASSIGE\u6280\u672f\u7684\u8bd5\u5242\u3002<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Prime \u9996\u5e2d\u6267\u884c\u5b98Keith Gottesdiener\u672c\u6708\u65e9\u4e9b\u65f6\u5019\u5728\u6469\u6839\u58eb\u4e39\u5229\u7684\u4e00\u6b21\u6d3b\u52a8\u4e2d\u8ba8\u8bba\u4e86 PASSIGE \u7684\u5438\u5f15\u529b\u3002 PASSIGE\u53ef\u4ee5\u8fdb\u5165\u57fa\u56e0\u7ec4\u5e76\u8fdb\u884c\u7cbe\u786e\u7684\u6cbb\u7597\u6027\u4fee\u6b63\uff0c\u800c\u4e0d\u9700\u8981\u5728\u57fa\u56e0\u7ec4\u7684\u5176\u4ed6\u5730\u65b9\u4e71\u52a8\uff0c\u8fd9\u5bf9\u533b\u751f\u548c\u75c5\u4eba\u6765\u8bf4\u90fd\u975e\u5e38\u91cd\u8981\uff0c\u53ef\u80fd\u5bf9\u76d1\u7ba1\u673a\u6784\u63a5\u53d7\u57fa\u56e0\u7f16\u8f91\u65b9\u6cd5\u4e5f\u975e\u5e38\u91cd\u8981\u3002<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">BMS\u7684\u4ea4\u6613\u5305\u62ec14\u4ebf\u7f8e\u5143\u7684\u5f00\u53d1\u91cc\u7a0b\u7891\uff0c\u662f\u7f13\u89e3Prime\u73b0\u91d1\u62c5\u5fe7\u7684\u4e24\u4ef6\u4e8b\u4e4b\u4e00\u3002Prime \u516c\u53f8\u6700\u8fd1\u66fe\u8b66\u544a\u6295\u8d44\u8005\uff0c\u6301\u7eed 12 \u4e2a\u6708\u7684\u7ecf\u8425\u80fd\u529b\u4ee4\u4eba\u4e25\u91cd\u6000\u7591\u3002\u9664\u4e86\u901a\u8fc7 BMS \u4ea4\u6613\u5f15\u5165\u73b0\u91d1\u5916\uff0cPrime \u8fd8\u5728\u91c7\u53d6\u63aa\u65bd\u51cf\u7f13\u8d44\u91d1\u7684\u6d41\u51fa\u901f\u5ea6\u3002<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">\u5728\u8840\u6db2\u5b66\u3001\u514d\u75ab\u5b66\u548c\u80bf\u7624\u5b66\u9886\u57df\uff0cPrime\u6b63\u4e13\u6ce8\u4e8e\u4e24\u4e2a\u4f53\u5916\u81ea\u4f53\u9020\u8840\u5e72\u7ec6\u80de\u9879\u76ee\uff0c\u7528\u4e8e\u6cbb\u7597\u4e0d\u540c\u5f62\u5f0f\u7684\u6162\u6027\u8089\u82bd\u80bf\u75c5\u3002\u6700\u5148\u8fdb\u8d44\u4ea7\u7684\u521d\u6b65\u4e34\u5e8a\u6570\u636e\u5c06\u4e8e2025\u5e74\u516c\u5e03\u3002Prime\u516c\u53f8\u5df2\u5c06\u5a01\u5c14\u900a\u6c0f\u75c5\u9879\u76ee\u786e\u5b9a\u4e3a\u809d\u75c5\u5de5\u4f5c\u7684\u91cd\u70b9\uff0c\u8be5\u9879\u76ee\u53ef\u80fd\u4e8e2026\u5e74\u8fdb\u5165\u4e34\u5e8a\u3002\u56ca\u6027\u7ea4\u7ef4\u5316\u57fa\u91d1\u4f1a\uff08Cystic Fibrosis Foundation\uff09\u7684\u8d44\u52a9\u5c06\u4f7f Prime \u80fd\u591f\u7ee7\u7eed\u5f00\u5c55\u56ca\u6027\u7ea4\u7ef4\u5316\u65b9\u9762\u7684\u5de5\u4f5c\u3002<\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">\u9664\u6b64\u4e4b\u5916\uff0c\u8be5\u516c\u53f8\u8fd8\u5728\u5bfb\u627e\u5408\u4f5c\u4f19\u4f34\u6765\u63a8\u8fdb\u9879\u76ee\u3002<\/span><span class=\"s2\">Prime<\/span><span class=\"s1\">\u516c\u53f8\u7684\u4ea7\u54c1\u7ebf\u5305\u62ec\u7cd6\u539f\u8d2e\u79ef\u75c5<\/span><span class=\"s2\">1b<\/span><span class=\"s1\">\u3001\u89c6\u7f51\u819c\u8272\u7d20\u53d8\u6027\u548c\u5f17\u91cc\u5fb7\u96f7\u5e0c\u5171\u6d4e\u5931\u8c03\u7b49\u5df2\u8fbe\u5230\u5148\u5bfc\u4f18\u5316\u9636\u6bb5\u7684\u9879\u76ee\uff0c\u4ee5\u53ca\u5176\u4ed6\u9002\u5e94\u75c7\u7684\u53d1\u73b0\u9636\u6bb5\u9879\u76ee\u3002<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6700\u8fd1\uff0c\u533b\u836f\u4f01\u4e1aPrime Medicine \u5411\u6295\u8d44\u8005\u53d1\u51fa\u8b66\u544a\uff0c\u5bf9\u8be5\u516c\u53f8\u662f\u5426\u6709\u80fd\u529b\u7ef4\u6301 12 \u4e2a\u6708\u7684\u8fd0\u8425\u503c\u5f97\u6000\u7591 [&hellip;]<\/p>\n","protected":false},"author":9,"featured_media":553279,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[427],"tags":[820,455,747,925],"class_list":["post-553225","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-market-news-zh-hans","tag-820","tag-455","tag-747","tag-925","sectors-life-science-zh-hans","locations-us-zh-hans","exchange-nasdaq-zh-hans","exchange-nyse-zh-hans"],"acf":[],"_links":{"self":[{"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/posts\/553225","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/comments?post=553225"}],"version-history":[{"count":1,"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/posts\/553225\/revisions"}],"predecessor-version":[{"id":553233,"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/posts\/553225\/revisions\/553233"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/media\/553279"}],"wp:attachment":[{"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/media?parent=553225"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/categories?post=553225"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/tags?post=553225"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}