{"id":556115,"date":"2024-11-02T00:56:06","date_gmt":"2024-11-02T07:56:06","guid":{"rendered":"https:\/\/nai500.com\/?p=556115"},"modified":"2024-11-02T00:56:06","modified_gmt":"2024-11-02T07:56:06","slug":"crispr-%e5%9f%ba%e5%9b%a0%e7%bc%96%e8%be%91%e5%b0%86%e8%bf%8e%e6%9d%a5%e9%87%8d%e5%a4%a7%e7%aa%81%e7%a0%b4%e5%93%aa%e4%ba%9b%e8%82%a1%e7%a5%a8%e5%80%bc%e5%be%97%e5%85%b3%e6%b3%a8","status":"publish","type":"post","link":"https:\/\/nai500.com\/zh-hans\/blog\/2024\/11\/crispr-%e5%9f%ba%e5%9b%a0%e7%bc%96%e8%be%91%e5%b0%86%e8%bf%8e%e6%9d%a5%e9%87%8d%e5%a4%a7%e7%aa%81%e7%a0%b4%e5%93%aa%e4%ba%9b%e8%82%a1%e7%a5%a8%e5%80%bc%e5%be%97%e5%85%b3%e6%b3%a8\/","title":{"rendered":"CRISPR\u57fa\u56e0\u7f16\u8f91\u5c06\u8fce\u6765\u91cd\u5927\u7a81\u7834\uff0c\u54ea\u4e9b\u80a1\u7968\u503c\u5f97\u5173\u6ce8\uff1f"},"content":{"rendered":"

CRISPR\u57fa\u56e0\u7ec4\u7f16\u8f91\u591a\u5e74\u6765\u4e00\u76f4\u88ab\u5927\u8086\u5ba3\u4f20\u3002\u4f46CRISPR\u6280\u672f\u7684\u524d\u666f\u5c1a\u672a\u5b9e\u73b0\u3002\u4e0d\u8fc7\uff0c\u8fd9\u79cd\u60c5\u51b5\u53ef\u80fd\u4f1a\u5728\u672a\u6765\u51e0\u5e74\u53d1\u751f\u53d8\u5316\u3002\u57fa\u56e0\u7ec4\u5b66\u7684\u91cd\u5927\u7a81\u7834\u4ee5\u53ca\u67d0\u4e9b\u80a1\u7968\u7684\u6f5c\u5728\u7206\u70b8\u5f0f\u589e\u957f\u53ef\u80fd\u5373\u5c06\u5230\u6765\u3002<\/p>\n

\u591a\u5bb6\u516c\u53f8\u6b63\u5728\u4f7f\u7528CRISPR\u7f16\u8f91\u4eba\u7c7b\u57fa\u56e0\u7ec4\uff0c\u8bd5\u56fe\u6cbb\u7597\uff08\u751a\u81f3\u6cbb\u6108\uff09\u9057\u4f20\u75be\u75c5\u3002\u4f46CRISPR\u7684\u7528\u9014\u4e0d\u4ec5\u9650\u4e8e\u9057\u4f20\u75be\u75c5\u3002\u591a\u5bb6\u57fa\u56e0\u7f16\u8f91\u516c\u53f8\u8fd8\u9488\u5bf9\u5404\u79cd\u7c7b\u578b\u7684\u764c\u75c7\u3002\u7279\u522b\u662f\uff0cCRISPR\u88ab\u7528\u4e8e\u5f00\u53d1\u5d4c\u5408\u6297\u539f\u53d7\u4f53(CAR)T\u7ec6\u80de\u7597\u6cd5\uff0c\u5176\u4e2d\u514d\u75ab\u7ec6\u80de\u7ecf\u8fc7\u57fa\u56e0\u5de5\u7a0b\u6539\u9020\u4ee5\u653b\u51fb\u7279\u5b9a\u80bf\u7624\u3002\u5e76\u975e\u6bcf\u4e2a\u6295\u8d44\u8005\u90fd\u60f3\u8d2d\u4e70CRISPR\u57fa\u56e0\u7f16\u8f91\u80a1\u7968\u3002\u8fd9\u4e9b\u80a1\u7968\u5f80\u5f80\u98ce\u9669\u9ad8\u4e14\u6ce2\u52a8\u6027\u5927\u3002\u7136\u800c\uff0c\u5bf9\u4e8e\u4e0d\u89c4\u907f\u98ce\u9669\u7684\u79ef\u6781\u6295\u8d44\u8005\u6765\u8bf4\uff0c\u4ee5\u4e0b\u662f\u51e0\u53ea\u503c\u5f97\u8d2d\u4e70\u7684CRISPR\u57fa\u56e0\u7f16\u8f91\u80a1\u7968\u3002<\/p>\n

Beam Therapeutics<\/h2>\n

Beam Therapeutics<\/a>\u7684\u78b1\u57fa\u7f16\u8f91\u65b9\u6cd5\u5177\u6709\u591a\u9879\u4f18\u52bf\u3002\u8fd9\u4e9b\u4f18\u52bf\u5305\u62ec\u80fd\u591f\u7cbe\u786e\u7784\u51c6\u7279\u5b9a\u57fa\u56e0\u5e8f\u5217\u5e76\u7f16\u8f91\u57fa\u56e0\uff0c\u800c\u4e0d\u4f1a\u4ea7\u751f\u610f\u5916\u540e\u679c\uff0c\u4f8b\u5982\u4ee5\u6bd4\u8ba1\u5212\u66f4\u5927\u7684\u89c4\u6a21\u91cd\u65b0\u6392\u5217\u57fa\u56e0\u7ec4\u3002\u8be5\u516c\u53f8\u6b63\u5728\u8bc4\u4f30\u56db\u79cd\u5904\u4e8e1\/2\u671f\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\u7684\u5019\u9009\u836f\u7269\uff0c\u8fd9\u4e9b\u836f\u7269\u9488\u5bf9\u7684\u662f\u7f55\u89c1\u7684\u9057\u4f20\u75be\u75c5\u9570\u72b6\u7ec6\u80de\u75c5\u3001\u03b1-1\u6297\u80f0\u86cb\u767d\u9176\u7f3a\u4e4f\u75c7(AATD)\u548c\u7cd6\u539f\u7d2f\u79ef\u75c51a(GSD1a)\u4ee5\u53caT\u7ec6\u80de\u767d\u8840\u75c5\/\u6dcb\u5df4\u7624\u3002<\/p>\n

CRISPR Therapeutics<\/h2>\n

CRISPR Therapeutics<\/a>\u662f\u552f\u4e00\u4e00\u5bb6\u4e13\u6ce8\u4e8eCRISPR\u7684\u751f\u7269\u79d1\u6280\u80a1\u7968\u3002\u8be5\u516c\u53f8\u53ca\u5176\u5408\u4f5c\u4f19\u4f34Vertex Pharmaceuticals (VRTX)<\/a>\u4e8e2023\u5e7412\u6708\u83b7\u5f97\u4e86\u7f8e\u56fd\u76d1\u7ba1\u673a\u6784\u5bf9Casgevy\u7684\u6279\u51c6\uff0c\u7528\u4e8e\u6cbb\u7597\u9570\u72b6\u7ec6\u80de\u75c5\uff0c\u5e76\u4e8e2024\u5e741\u6708\u83b7\u5f97\u4e86\u6cbb\u7597\u8f93\u8840\u4f9d\u8d56\u6027\u03b2-\u5730\u4e2d\u6d77\u8d2b\u8840\u7684\u6279\u51c6\u3002<\/p>\n

\u5c3d\u7ba1\u6240\u6709CRISPR\u80a1\u7968\u90fd\u6709\u98ce\u9669\uff0c\u4f46CRISPR Therapeutics\u7684\u98ce\u9669\u53ef\u4ee5\u8bf4\u6bd4\u5927\u591a\u6570\u80a1\u7968\u90fd\u8981\u5c0f\u3002\u8be5\u516c\u53f8\u62e5\u6709\u5f3a\u5927\u7684\u73b0\u91d1\u72b6\u51b5\uff0c\u8fd9\u4e3b\u8981\u5f52\u529f\u4e8e\u4e0eVertex\u7684\u5408\u4f5c\uff0c\u5e76\u4e14\u5e02\u573a\u4e0a\u6709\u4e00\u6b3e\u83b7\u6279\u4ea7\u54c1\u3002<\/p>\n

Editas Medicine<\/h2>\n

Editas Medicine<\/a>\u5728\u4f7f\u7528CRISPR\u6cbb\u7597\u7f55\u89c1\u9057\u4f20\u6027\u773c\u75c5\u65b9\u9762\u5904\u4e8e\u9886\u5148\u5730\u4f4d\u3002\u7136\u800c\uff0c\u5728\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u4ee4\u4eba\u5931\u671b\u540e\uff0c\u8be5\u516c\u53f8\u6700\u7ec8\u653e\u5f03\u4e86\u8fd9\u4e9b\u52aa\u529b\u3002<\/p>\n

\u4f46Editas\u4ecd\u7136\u5bf9\u4e3b\u8981\u5019\u9009\u836f\u7269reni-cel\uff08\u4ee5\u524d\u79f0\u4e3aEDIT-301\uff09\u5bc4\u4e88\u539a\u671b\u3002\u8be5\u516c\u53f8\u6b63\u5728\u540e\u671f\u7814\u7a76\u4e2d\u8bc4\u4f30\u8be5\u5b9e\u9a8c\u7597\u6cd5\u4f5c\u4e3a\u9570\u72b6\u7ec6\u80de\u75c5\u7684\u6cbb\u7597\u65b9\u6cd5\uff0c\u5e76\u5728\u8fdb\u884c\u9488\u5bf9\u03b2-\u5730\u4e2d\u6d77\u8d2b\u8840\u7684\u65e9\u671f\u7814\u7a76\u3002<\/p>\n

\u8be5\u516c\u53f8\u8ba4\u4e3a\uff0creni-cel\u53ef\u80fd\u662f\u6cbb\u7597\u9570\u72b6\u7ec6\u80de\u75c5\u548c\u03b2-\u5730\u4e2d\u6d77\u8d2b\u8840\u7684\u201c\u4e00\u6d41\u201d\u7597\u6cd5\u3002\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u4e34\u5e8a\u8bd5\u9a8c\u7684\u7ed3\u679c\u4ee4\u4eba\u9f13\u821e\u3002Editas\u8fd8\u5728\u7ee7\u7eed\u5f00\u53d1\u4f53\u5185\u7597\u6cd5\u3002\u4e0d\u8fc7\uff0c\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u8be5\u516c\u53f8\u8fd8\u6ca1\u6709\u5c06\u4efb\u4f55\u5176\u4ed6\u4f53\u5185\u9879\u76ee\u63a8\u8fdb\u5230\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

CRISPR\u57fa\u56e0\u7ec4\u7f16\u8f91\u591a\u5e74\u6765\u4e00\u76f4\u88ab\u5927\u8086\u5ba3\u4f20\u3002\u4f46CRISPR\u6280\u672f\u7684\u524d\u666f\u5c1a\u672a\u5b9e\u73b0\u3002\u4e0d\u8fc7\uff0c\u8fd9\u79cd\u60c5\u51b5\u53ef\u80fd\u4f1a\u5728\u672a\u6765\u51e0\u5e74\u53d1 […]<\/p>\n","protected":false},"author":9,"featured_media":556116,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[427],"tags":[820,455,747,925],"class_list":["post-556115","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-market-news-zh-hans","tag-820","tag-455","tag-747","tag-925","sectors-life-science-zh-hans","locations-us-zh-hans","exchange-nasdaq-zh-hans","exchange-nyse-zh-hans"],"acf":[],"_links":{"self":[{"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/posts\/556115","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/comments?post=556115"}],"version-history":[{"count":1,"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/posts\/556115\/revisions"}],"predecessor-version":[{"id":556123,"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/posts\/556115\/revisions\/556123"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/media\/556116"}],"wp:attachment":[{"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/media?parent=556115"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/categories?post=556115"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/tags?post=556115"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}