{"id":569420,"date":"2025-03-20T23:16:45","date_gmt":"2025-03-21T06:16:45","guid":{"rendered":"https:\/\/nai500.com\/?p=569420"},"modified":"2025-03-20T23:16:45","modified_gmt":"2025-03-21T06:16:45","slug":"%e7%be%8e%e8%82%a1%e5%9f%ba%e5%9b%a0%e7%bc%96%e8%be%91%e8%82%a1%e7%a5%a8%e6%8a%95%e8%b5%84%e6%8c%87%e5%8d%97%e5%8f%8a%e7%b2%be%e9%80%89%e4%b8%aa%e8%82%a1","status":"publish","type":"post","link":"https:\/\/nai500.com\/zh-hans\/blog\/2025\/03\/%e7%be%8e%e8%82%a1%e5%9f%ba%e5%9b%a0%e7%bc%96%e8%be%91%e8%82%a1%e7%a5%a8%e6%8a%95%e8%b5%84%e6%8c%87%e5%8d%97%e5%8f%8a%e7%b2%be%e9%80%89%e4%b8%aa%e8%82%a1\/","title":{"rendered":"\u7f8e\u80a1\u57fa\u56e0\u7f16\u8f91\u80a1\u7968\u6295\u8d44\u6307\u5357\u53ca\u7cbe\u9009\u4e2a\u80a1"},"content":{"rendered":"<p>2020\u5e74\uff0c\u7f8e\u56fd\u751f\u7269\u5316\u5b66\u5bb6Jennifer Doudna\u4e0e\u6cd5\u56fd\u5fae\u751f\u7269\u5b66\u5bb6Emmanuelle Charpentier\u56e0\u53d1\u73b0CRISPR\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u8363\u83b7\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u3002\u745e\u5178\u7687\u5bb6\u79d1\u5b66\u9662\u8bc4\u4ef7\u8fd9\u4e00\u53d1\u73b0\u201c\u6539\u5199\u4e86\u751f\u547d\u7684\u5bc6\u7801\u201d\uff0c\u4e3a\u533b\u5b66\u9886\u57df\u5f00\u542f\u9769\u547d\u6027\u53ef\u80fd\u3002\u5728\u8d44\u672c\u5e02\u573a\u4e0a\uff0c\u57fa\u56e0\u7f16\u8f91\u80a1\u7968\u4e5f\u7eb7\u7eb7\u6d8c\u73b0\uff0c\u4e3a\u6295\u8d44\u8005\u63d0\u4f9b\u4e86\u65b0\u7684\u6295\u8d44\u673a\u4f1a\u3002<\/p>\n<p>\u57fa\u56e0\u7f16\u8f91\u5e02\u573a\u9884\u8ba1\u52302032\u5e74\u5c06\u8fbe308\u4ebf\u7f8e\u5143\uff0c\u6838\u5fc3\u9a71\u52a8\u529b\u4e3aCRISPR\u6280\u672f\u5bf9\u9057\u4f20\u75be\u75c5\u7684\u6cbb\u7597\u6f5c\u529b\u3002\u8be5\u6280\u672f\u901a\u8fc7\u7cbe\u51c6\u4fee\u6539DNA\uff0c\u6709\u671b\u5b9e\u73b0\u201c\u4e00\u52b3\u6c38\u9038\u201d\u7684\u6cbb\u6108\u65b9\u6848\uff0c\u8986\u76d6\u9570\u72b6\u7ec6\u80de\u8d2b\u8840\u3001\u7f55\u89c1\u4ee3\u8c22\u75c5\u3001\u764c\u75c7\u7b49\u9886\u57df\u3002\u5982\u300a\u5bc6\u7801\u7834\u8bd1\u8005\u300b\u4f5c\u8005Walter Isaacson\u6240\u8a00\uff0cCRISPR\u5c06\u201c\u91cd\u5851\u4eba\u7c7b\u672a\u6765\u201d\u3002<\/p>\n<h2>\u6295\u8d44\u7b56\u7565\u4e0e\u98ce\u9669\u63d0\u793a<\/h2>\n<p><strong>\u7b56\u7565\u5efa\u8bae<\/strong>\uff1a<\/p>\n<ul>\n<li><strong>\u7ec4\u5408\u5206\u6563\uff1a<\/strong>\u57fa\u56e0\u7f16\u8f91\u884c\u4e1a\u6ce2\u52a8\u6027\u9ad8\uff0c\u5efa\u8bae\u914d\u7f6e\u591a\u53ea\u80a1\u7968\uff08\u5982Intellia+CRISPR+Beam\uff09\u4ee5\u5e73\u8861\u98ce\u9669\u3002<\/li>\n<li><strong>\u957f\u671f\u6301\u6709\uff1a<\/strong>\u836f\u7269\u7814\u53d1\u5468\u671f\u957f\uff085-10\u5e74\uff09\uff0c\u9700\u8010\u5fc3\u7b49\u5f85\u7ba1\u7ebf\u63a8\u8fdb\u4e0e\u5546\u4e1a\u5316\u653e\u91cf\u3002<\/li>\n<li><strong>\u5173\u6ce8\u91cc\u7a0b\u7891\uff1a<\/strong>\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u3001FDA\u5ba1\u6279\u3001\u5408\u4f5c\u4f19\u4f34\u52a8\u6001\u4e3a\u80a1\u4ef7\u5173\u952e\u50ac\u5316\u5242\u3002<\/li>\n<\/ul>\n<p><strong>\u98ce\u9669\u8b66\u793a<\/strong>\uff1a<\/p>\n<ul>\n<li><strong>\u6280\u672f\u4e0d\u786e\u5b9a\u6027<\/strong>\uff1a\u57fa\u56e0\u7f16\u8f91\u53ef\u80fd\u5f15\u53d1\u8131\u9776\u6548\u5e94\uff0c\u957f\u671f\u5b89\u5168\u6027\u9700\u9a8c\u8bc1\u3002<\/li>\n<li><strong>\u653f\u7b56\u76d1\u7ba1<\/strong>\uff1a\u4f26\u7406\u4e89\u8bae\u4e0e\u5404\u56fd\u6cd5\u89c4\u53ef\u80fd\u5f71\u54cd\u7814\u53d1\u8fdb\u5ea6\u3002<\/li>\n<li><strong>\u5e02\u573a\u6ce2\u52a8<\/strong>\uff1a\u4f01\u4e1a\u4f9d\u8d56\u878d\u8d44\uff0c\u80a1\u4ef7\u6613\u53d7\u4e34\u5e8a\u6570\u636e\u6216\u884c\u4e1a\u60c5\u7eea\u5f71\u54cd\u5267\u70c8\u6ce2\u52a8\u3002<\/li>\n<\/ul>\n<h2>\u6838\u5fc3\u4f01\u4e1a\u5206\u6790\u4e0e\u6295\u8d44\u6807\u7684<\/h2>\n<p>\u4ee5\u4e0b\u4e09\u53ea\u57fa\u56e0\u7f16\u8f91\u80a1\u7968\u503c\u5f97\u5173\u6ce8\uff08\u6570\u636e\u622a\u81f32025\u5e743\u670820\u65e5\uff09\uff1a<\/p>\n<table>\n<thead>\n<tr>\n<td><strong>\u516c\u53f8\u540d\u79f0<\/strong><\/td>\n<td><strong>\u80a1\u7968\u4ee3\u7801<\/strong><\/td>\n<td><strong>\u5e02\u503c<\/strong><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Intellia Therapeutics<\/td>\n<td><a href=\"https:\/\/nai500.com\/zh-hans\/%e8%82%a1%e7%a5%a8%e6%9f%a5%e8%af%a2\/?qm_symbol=NTLA\">NASDAQ:NTLA<\/a><\/td>\n<td>9.63\u4ebf\u7f8e\u5143<\/td>\n<\/tr>\n<tr>\n<td>CRISPR Therapeutics<\/td>\n<td>NASDAQ:CRSP<\/td>\n<td>\u6570\u636e\u6682\u7f3a<\/td>\n<\/tr>\n<tr>\n<td>Beam Therapeutics<\/td>\n<td>NASDAQ:BEAM<\/td>\n<td>20\u4ebf\u7f8e\u5143<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3>1. Intellia Therapeutics<\/h3>\n<ul>\n<li><strong>\u521b\u59cb\u4eba<\/strong>\uff1a\u8bfa\u8d1d\u5c14\u5956\u5f97\u4e3bJennifer Doudna\u4e8e2014\u5e74\u8054\u5408\u521b\u7acb\u3002<\/li>\n<li><strong>\u6280\u672f\u4eae\u70b9<\/strong>\uff1a\u4e13\u6ce8<strong>\u4f53\u5185\u57fa\u56e0\u7f16\u8f91<\/strong>\uff08in vivo\uff09\uff0c\u4e0e\u518d\u751f\u5143\uff08Regeneron\uff09\u5408\u4f5c\u5f00\u53d1CRISPR-Cas9\u7597\u6cd5\u3002\n<ul>\n<li><strong>nexiguran ziclumeran\uff08\u524d\u79f0NTLA-2001\uff09<\/strong>\uff1a\u9488\u5bf9\u8f6c\u7532\u72b6\u817a\u7d20\u86cb\u767d\u6dc0\u7c89\u6837\u53d8\u6027\uff08ATTR\uff09\u7684\u540e\u671f\u4e34\u5e8a\u5019\u9009\u836f\u7269\u3002<\/li>\n<li><strong>NTLA-2002<\/strong>\uff1a\u8ba1\u52122026\u5e74\u5411\u7f8e\u56fdFDA\u7533\u8bf7\u6279\u51c6\u6cbb\u7597\u9057\u4f20\u6027\u8840\u7ba1\u6027\u6c34\u80bf\uff0c2027\u5e74\u4e0a\u5e02\u3002<\/li>\n<li><strong>B\u578b\u8840\u53cb\u75c5\u7597\u6cd5<\/strong>\uff1a\u518d\u751f\u5143\u4e3b\u5bfc\u7684II\u671f\u4e34\u5e8a\u9879\u76ee\uff0cIntellia\u6709\u671b\u83b7\u5f97\u91cc\u7a0b\u7891\u4ed8\u6b3e\u4e0e\u9500\u552e\u5206\u6210\u3002<\/li>\n<\/ul>\n<\/li>\n<li><strong>\u4f18\u52bf<\/strong>\uff1a\u6280\u672f\u9a8c\u8bc1\u65e9\uff0c\u5408\u4f5c\u4f19\u4f34\u5b9e\u529b\u5f3a\u52b2\uff0c\u7ba1\u7ebf\u8986\u76d6\u591a\u4e2a\u9002\u5e94\u75c7\u3002<\/li>\n<\/ul>\n<h3>2. CRISPR Therapeutics<\/h3>\n<ul>\n<li><strong>\u521b\u59cb\u4eba<\/strong>\uff1a\u8bfa\u5956\u5f97\u4e3bEmmanuelle Charpentier\u4e8e2013\u5e74\u8054\u5408\u521b\u7acb\u3002<\/li>\n<li><strong>\u91cc\u7a0b\u7891<\/strong>\uff1a2023\u5e7412\u6708\u4e0e\u798f\u6cf0\u5236\u836f\uff08Vertex\uff09\u63a8\u51fa\u5168\u7403\u9996\u6b3eCRISPR\u7597\u6cd5<strong>Casgevy<\/strong>\uff0c\u83b7\u6279\u6cbb\u7597\u9570\u72b6\u7ec6\u80de\u75c5\u4e0e\u8f93\u8840\u4f9d\u8d56\u578b\u03b2\u5730\u4e2d\u6d77\u8d2b\u8840\u3002<\/li>\n<\/ul>\n<ul>\n<li><strong>\u7814\u53d1\u7ba1\u7ebf\uff1a<\/strong>\n<ul>\n<li><strong>\u540c\u79cd\u5f02\u4f53CAR-T\u7597\u6cd5\uff1a<\/strong>CTX112\u4e0eCTX131\u8fdb\u5165\u4e34\u5e8a\uff0c\u5c5e\u4e8e\u65e0\u9700\u5b9a\u5236\u5316\u6539\u9020\u6216\u4e2a\u6027\u5316\u8c03\u6574\u7684\u73b0\u6210\uff08off-the-shelf\uff09\u7597\u6cd5\u3002<\/li>\n<li><strong>\u4f53\u5185\u57fa\u56e0\u7f16\u8f91\u7597\u6cd5\uff1a<\/strong>\u5904\u4e8e\u65e9\u671f\u4e34\u5e8a\u7814\u7a76\u9636\u6bb5\u3002<\/li>\n<li><strong>1\u578b\u7cd6\u5c3f\u75c5\u7597\u6cd5\uff1a<\/strong>2025\u5e74\u516c\u5e03\u4e34\u5e8a\u8bd5\u9a8c\u8fdb\u5c55\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li><strong>\u4f18\u52bf<\/strong>\uff1a\u9996\u4e2a\u5546\u4e1a\u5316CRISPR\u7597\u6cd5\u843d\u5730\uff0c\u73b0\u91d1\u6d41\u6f5c\u529b\u5927\uff0c\u5408\u4f5c\u65b9\u798f\u6cf0\u5177\u5907\u5f3a\u5927\u9500\u552e\u7f51\u7edc\u3002<\/li>\n<\/ul>\n<h3>3. Beam Therapeutics<\/h3>\n<ul>\n<li><strong>\u521b\u59cb\u4eba<\/strong>\uff1a\u57fa\u56e0\u7f16\u8f91\u5148\u9a71\u5f20\u950b\uff08Feng Zhang\uff09\u4e0e\u5218\u5982\u8c26\uff08David Liu\uff09\u4e8e2017\u5e74\u521b\u7acb\u3002<\/li>\n<li><strong>\u6280\u672f\u7a81\u7834<\/strong>\uff1a\u5f00\u53d1<strong>\u78b1\u57fa\u7f16\u8f91<\/strong>\uff08Base Editing\uff09\uff0c\u4ee5\u201c\u5206\u5b50\u94c5\u7b14\u201d\u7cbe\u51c6\u62b9\u9664\u548c\u6539\u5199\uff0c\u800c\u975e\u6572\u9664\u53d8\u5f02\uff0c\u907f\u514d\u4f20\u7edfCRISPR\u7684DNA\u53cc\u94fe\u65ad\u88c2\u98ce\u9669\u3002<\/li>\n<li><strong>\u6838\u5fc3\u7ba1\u7ebf<\/strong>\uff1a\n<ul>\n<li><strong>BEAM-302<\/strong>\uff1a\u9488\u5bf9\u03b1-1\u6297\u80f0\u86cb\u767d\u9176\u7f3a\u4e4f\u75c7\uff08AATD\uff09\u7684I\/II\u671f\u4e34\u5e8a\u6570\u636e\u79ef\u6781\u3002<\/li>\n<li><strong>BEAM-101<\/strong>\uff1a\u5904\u4e8e\u65e9\u671f\u4e34\u5e8a\u9636\u6bb5\uff0c\u6cbb\u7597\u9570\u72b6\u7ec6\u80de\u75c5\u3002<\/li>\n<li><strong>BEAM-301<\/strong>\uff1a\u9488\u5bf9\u7cd6\u539f\u8d2e\u79ef\u75c71a\u578b\u7684\u7f55\u89c1\u75c5\u7597\u6cd5\u3002<\/li>\n<\/ul>\n<\/li>\n<li><strong>\u4f18\u52bf<\/strong>\uff1a\u6280\u672f\u8fed\u4ee3\u6f5c\u529b\u5927\uff0c\u9002\u5e94\u75c7\u805a\u7126\u9ad8\u672a\u6ee1\u8db3\u9700\u6c42\u9886\u57df\u3002<\/li>\n<\/ul>\n<h2>\u7ed3\u8bed<\/h2>\n<p>\u57fa\u56e0\u7f16\u8f91\u8d5b\u9053\u5904\u4e8e\u7206\u53d1\u524d\u591c\uff0c\u4e0a\u8ff0\u4e09\u5bb6\u516c\u53f8\u5206\u522b\u4ee3\u8868<strong>\u4f53\u5185\u7f16\u8f91<\/strong>\uff08Intellia\uff09\u3001<strong>\u9996\u6b3e\u5546\u4e1a\u5316<\/strong>\uff08CRISPR\uff09\u4e0e<strong>\u6280\u672f\u8fed\u4ee3<\/strong>\uff08Beam\uff09\u7684\u5dee\u5f02\u5316\u8def\u5f84\u3002\u5bf9\u98ce\u9669\u627f\u53d7\u80fd\u529b\u8f83\u5f3a\u7684\u6295\u8d44\u8005\uff0c\u53ef\u5c06\u5176\u4f5c\u4e3a\u201c\u57fa\u56e0\u7ec4\u9769\u547d\u201d\u957f\u671f\u5e03\u5c40\u7684\u4e00\u90e8\u5206\uff0c\u5206\u4eab\u751f\u7269\u79d1\u6280\u98a0\u8986\u6027\u521b\u65b0\u7684\u7ea2\u5229\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>2020\u5e74\uff0c\u7f8e\u56fd\u751f\u7269\u5316\u5b66\u5bb6Jennifer Doudna\u4e0e\u6cd5\u56fd\u5fae\u751f\u7269\u5b66\u5bb6Emmanuelle Charpent [&hellip;]<\/p>\n","protected":false},"author":27,"featured_media":569421,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[1521,430],"tags":[820,455,747,925],"class_list":["post-569420","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-1521","category-trends-strategies-zh-hans","tag-820","tag-455","tag-747","tag-925","sectors-life-science-zh-hans","locations-us-zh-hans","exchange-nasdaq-zh-hans"],"acf":[],"_links":{"self":[{"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/posts\/569420","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/users\/27"}],"replies":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/comments?post=569420"}],"version-history":[{"count":4,"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/posts\/569420\/revisions"}],"predecessor-version":[{"id":569431,"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/posts\/569420\/revisions\/569431"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/media\/569421"}],"wp:attachment":[{"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/media?parent=569420"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/categories?post=569420"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/tags?post=569420"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}