Tharimmune \u80a1\u4ef7\u66b4\u6da8\uff0c\u6b64\u524d\u516c\u53f8\u79f0\u5176 TH-104 \u9879\u76ee\u7684\u65b0\u836f\u4ee3\u52a8\u529b\u5b66\u6a21\u62df\u663e\u793a\uff0c\u53ef\u80fd\u5728\u5bf9\u6297\u82ac\u592a\u5c3c\u5f15\u8d77\u7684\u547c\u5438\u6291\u5236\u65b9\u9762\u5177\u6709\u66f4\u4f18\u7684\u7279\u6027\u3002\u8be5\u5fae\u578b\u5e02\u503c\u516c\u53f8\u5728 8 \u6708 20 \u65e5\u6536\u4e8e 3.59\uff0c\u6da8\u5e45 206.84%\uff0c\u4ea4\u6613\u8005\u5728\u4e00\u8f6e\u77e5\u8bc6\u4ea7\u6743\u80dc\u5229\u548c\u660e\u786e\u50ac\u5316\u5242\u4e4b\u540e\uff0c\u7eb7\u7eb7\u62bc\u6ce8\u4e8e\u751f\u7269\u9632\u5fa1\u517c\u5e94\u5bf9\u963f\u7247\u7c7b\u5371\u673a\u7684\u53d9\u4e8b\uff0c\u4f7f\u5176\u7a81\u7136\u5177\u6709\u53ef\u6295\u8d44\u6027\u3002<\/p>\n
\u80a1\u4ef7\u98d9\u5347\u4e0e\u80cc\u666f\uff1a \u6b64\u6b21\u4e0a\u6da8\u6807\u5fd7\u7740 Tharimmune \u7ecf\u5386\u4e86\u4e00\u4e2a\u53cd\u590d\u65e0\u5e38\u7684\u5e74\u4efd\uff0c\u8be5\u80a1\u5728 2024 \u5e74 4 \u6708\u66fe\u89e6\u53ca 52 \u5468\u4f4e\u70b9 0.95\uff0c5 \u6708\u66fe\u6da8\u81f3\u6b64\u524d\u9ad8\u70b9 6.45\u3002\u5468\u4e8c\u7684\u66b4\u6da8\u53d1\u751f\u5728\u516c\u53f8\u66f4\u65b0\u79f0\u5176\u5efa\u6a21\u8868\u660e TH-104 \u5728\u7f13\u89e3\u7531\u82ac\u592a\u5c3c\u53ca\u5176\u4ed6\u5f3a\u6548\u963f\u7247\u7c7b\u836f\u7269\u5f15\u8d77\u7684\u547c\u5438\u6291\u5236\u65b9\u9762\uff0c\u53ef\u80fd\u4f18\u4e8e\u73b0\u6709\u65b9\u6cd5\u4e4b\u540e\u3002\u8be5\u80a1\u56e0\u6ce2\u52a8\u591a\u6b21\u505c\u724c\uff0c\u5e76\u5728\u63a5\u8fd1\u76d8\u4e2d\u9ad8\u4f4d\u6536\u76d8\uff0c\u5de9\u56fa\u4e86\u7eb3\u65af\u8fbe\u514b\u4eca\u5e74\u6700\u5927\u5355\u65e5\u6da8\u5e45\u4e4b\u4e00\u3002\u5bf9\u4e8e\u5fae\u578b\u80a1\uff0c\u4ef7\u683c\u53ef\u4ee5\u5f15\u9886\u53d9\u4e8b\u3002\u5728\u8fd9\u91cc\uff0c\u53d9\u4e8b\u672c\u8eab\u5177\u6709\u5f3a\u70c8\u5438\u5f15\u529b\uff1a\u4e00\u79cd\u6f5c\u5728\u7684\u89e3\u836f\u7528\u4e8e\u5904\u4e8e\u516c\u5171\u536b\u751f\u548c\u56fd\u5bb6\u5b89\u5168\u6838\u5fc3\u7684\u836f\u7269\u3002\u8fd9\u79cd\u7ec4\u5408\u5438\u5f15\u4e86\u52a8\u91cf\u8d44\u91d1\u3001\u653f\u7b56\u5173\u6ce8\u8005\u548c\u6295\u673a\u6027\u751f\u7269\u79d1\u6280\u57fa\u91d1\u7684\u540c\u7b49\u5173\u6ce8\u3002<\/p>\n
TH-104 \u8bd5\u56fe\u505a\u4ec0\u4e48\uff1a Tharimmune \u7684\u7406\u8bba\u5f88\u76f4\u63a5\u3002\u5f53\u524d\u4e00\u7ebf\u7684\u9006\u8f6c\u5242\u2014\u2014\u7eb3\u6d1b\u916e\u4ee5\u53ca\u6700\u8fd1\u7684\u7eb3\u7f8e\u82ac\u2014\u2014\u5728\u9762\u5bf9\u50cf\u82ac\u592a\u5c3c\u8fd9\u6837\u9ad8\u6548\u5408\u6210\u7269\u65f6\u53ef\u80fd\u53d7\u5230\u6311\u6218\uff0c\u6b64\u7c7b\u7269\u8d28\u7684\u8d77\u6548\u901f\u5ea6\u5feb\u3001\u518d\u9547\u9759\u98ce\u9669\u548c\u4f5c\u7528\u6301\u7eed\u65f6\u95f4\u53d8\u5f97\u81f3\u5173\u91cd\u8981\u3002\u516c\u53f8\u8868\u793a\uff0c\u5176\u6a21\u62df\u663e\u793a TH-104 \u5728\u5e94\u5bf9\u82ac\u592a\u5c3c\u7c7b\u963f\u7247\u5f15\u8d77\u7684\u547c\u5438\u6291\u5236\u65b9\u9762\uff0c\u53ef\u80fd\u6bd4\u73b0\u6709\u836f\u7269\u63d0\u4f9b\u66f4\u6709\u5229\u7684\u66b4\u9732\u8c31\u3002\u8fd9\u5e76\u975e\u4e34\u5e8a\u7597\u6548\u8bc1\u636e\uff0c\u4e5f\u4e0d\u662f FDA \u7684\u80cc\u4e66\u3002\u8fd9\u662f\u5efa\u6a21\u2014\u2014\u5982\u679c\u5047\u8bbe\u4e0e\u4eba\u4f53\u751f\u7269\u5b66\u76f8\u7b26\uff0c\u5219\u662f\u4e00\u4e2a\u65e9\u671f\u4f46\u53ef\u4fe1\u7684\u4fe1\u53f7\u3002\u6295\u8d44\u8005\u5b9e\u9645\u4e0a\u662f\u5728\u4e3a TH-104 \u53ef\u80fd\u5177\u6709\u7684\u9009\u62e9\u6743\u4e70\u5355\uff1a\u5b83\u8981\u4e48\u53ef\u4ee5\u7eb3\u5165\u533b\u9662\u7528\u4e8e\u7ba1\u7406\u82ac\u592a\u5c3c\u9547\u9759\u548c\u672f\u540e\u547c\u5438\u6291\u5236\u7684\u65b9\u6848\uff0c\u8981\u4e48\u66f4\u620f\u5267\u6027\u5730\uff0c\u4f5c\u4e3a\u5728\u5927\u89c4\u6a21\u66b4\u9732\u60c5\u666f\u4e2d\u53ef\u5728\u73b0\u573a\u90e8\u7f72\u7684\u5bf9\u6297\u63aa\u65bd\u3002<\/p>\n
\u4e13\u5229\u4e0e\u751f\u7269\u9632\u5fa1\u89d2\u5ea6\uff1a \u5728\u80a1\u4ef7\u66b4\u6da8\u4e00\u5468\u524d\uff0cTharimmune \u62ab\u9732\u4e86\u56f4\u7ed5 TH-104 \u7684\u5168\u7403\u65b0\u4e13\u5229\uff0c\u5e76\u5c06\u8be5\u836f\u5b9a\u4f4d\u4e3a\u9488\u5bf9\u6b66\u5668\u5316\u82ac\u592a\u5c3c\u7684\u56fd\u5bb6\u5b89\u5168\u533b\u7597\u5bf9\u6297\u63aa\u65bd\u3002\u8fd9\u79cd\u8868\u8ff0\u5f88\u91cd\u8981\u3002\u7f8e\u56fd\u7684\u673a\u6784\u5982 BARDA \u548c ASPR \u6709\u4e3a\u88ab\u89c6\u4e3a\u5bf9\u516c\u5171\u51c6\u5907\u81f3\u5173\u91cd\u8981\u7684\u5bf9\u6297\u63aa\u65bd\u63d0\u4f9b\u540e\u671f\u5f00\u53d1\u548c\u91c7\u8d2d\u8d44\u91d1\u7684\u901a\u9053\u3002Project BioShield \u53ca\u5176\u540e\u7eed\u6388\u6743\u5b58\u5728\uff0c\u4ee5\u4fbf\u653f\u5e9c\u53ef\u4ee5\u4e3a\u90a3\u4e9b\u5546\u4e1a\u9700\u6c42\u4e0d\u53ef\u9884\u6d4b\u4f46\u5c0f\u4f17\u4e14\u5fc5\u9700\u7684\u4ea7\u54c1\u652f\u4ed8\u8d39\u7528\uff0c\u4f7f\u5176\u53ef\u7528\u3002\u963f\u7247\u7c7b\u9006\u8f6c\u9886\u57df\u5e76\u975e\u7a7a\u767d\u2014\u2014\u975e\u5904\u65b9 Narcan \u666e\u53ca\uff0cIndivior \u5728 2023 \u5e74\u83b7\u6279 OPVEE\uff08\u7eb3\u7f8e\u82ac\uff09\u2014\u2014\u56e0\u6b64 TH-104 \u5fc5\u987b\u5728\u6d89\u53ca\u5408\u6210\u7269\u65f6\u663e\u793a\u51fa\u660e\u663e\u4f18\u52bf\u3002\u4f46\u5728\u9009\u4e3e\u5e74\u8fa9\u8bba\u548c\u56fd\u571f\u5b89\u5168\u7b80\u62a5\u4e2d\u82ac\u592a\u5c3c\u5904\u4e8e\u6838\u5fc3\u4f4d\u7f6e\u65f6\uff0c\u4e00\u4e2a\u53ef\u4fe1\u7684\u5dee\u5f02\u5316\u56e0\u7d20\u53ef\u80fd\u4f1a\u5f00\u542f\u975e\u7a00\u91ca\u6027\u8d44\u91d1\uff0c\u4ece\u800c\u964d\u4f4e\u5f00\u53d1\u98ce\u9669\u3002<\/p>\n
\u8d22\u52a1\u73b0\u5b9e\u68c0\u9a8c\uff1a Tharimmune \u62a5\u544a\u7b2c\u4e8c\u5b63\u5ea6\u6bcf\u80a1\u4e8f\u635f -0.64\uff0c\u5c1a\u65e0\u5df2\u53d1\u5e03\u7684\u5171\u8bc6\u3002\u5bf9\u4e8e\u4e00\u5bb6\u5904\u4e8e\u5f00\u53d1\u9636\u6bb5\u7684\u751f\u7269\u79d1\u6280\u516c\u53f8\u6765\u8bf4\uff0c\u8fd9\u79cd\u4e8f\u635f\u6570\u636e\u5c5e\u6b63\u5e38\u3002\u76ee\u524d\u7684\u6838\u5fc3\u95ee\u9898\u662f\u73b0\u91d1\u7eed\u822a\u2014\u2014\u4ee5\u53ca\u7ba1\u7406\u5c42\u662f\u5426\u4f1a\u5728\u80a1\u4ef7\u5f3a\u52bf\u65f6\u5c1d\u8bd5\u52df\u8d44\u3002\u5386\u53f2\u8868\u660e\u4ed6\u4eec\u5e94\u8be5\u8fd9\u4e48\u505a\u3002\u50cf\u5468\u4e8c\u8fd9\u6837\u7684\u706b\u7bad\u884c\u60c5\u901a\u5e38\u4f1a\u968f\u540e\u51fa\u73b0 ATM \u52df\u8d44\u6216\u4e8c\u6b21\u53d1\u884c\uff0c\u5c06\u8d26\u9762\u6536\u76ca\u8f6c\u6362\u4e3a\u672a\u6765 12 \u5230 24 \u4e2a\u6708\u7814\u7a76\u7684\u71c3\u6599\u3002\u8fd9\u5e76\u975e\u60b2\u89c2\uff1b\u8fd9\u662f\u5e38\u89c1\u7b56\u7565\u3002\u5982\u679c\u516c\u53f8\u80fd\u5c06\u52df\u8d44\u4e0e\u6e05\u6670\u7684\u4e34\u5e8a\u524d\u8fdb\u5c55\u62ab\u9732\u3001IND \u65f6\u95f4\u8868\u4ee5\u53ca\u4efb\u4f55\u653f\u5e9c\u6216\u5b66\u672f\u5408\u4f5c\u76f8\u7ed3\u5408\uff0c\u6295\u8d44\u8005\u53ef\u80fd\u4f1a\u5bb9\u5fcd\u7a00\u91ca\u3002\u4ed6\u4eec\u65e0\u6cd5\u5bb9\u5fcd\u7684\u662f\u6c89\u9ed8\u6216\u9879\u76ee\u8303\u56f4\u8513\u5ef6\u3002\u5728\u88ab\u8bc1\u660e\u4e4b\u524d\uff0c\u8fd9\u4ecd\u7136\u662f\u4e00\u6b3e\u5355\u4e00\u4ea7\u54c1\u7684\u6545\u4e8b\u3002<\/p>\n
\u4ece\u5371\u673a\u89c6\u89d2\u7684\u4f30\u503c\uff1a \u5468\u4e8c\u7684\u4ef7\u683c\u8d70\u52bf\u8868\u660e\u5e02\u573a\u6b63\u5728\u4e3a\u4e24\u91cd\u91cd\u53e0\u673a\u4f1a\u8d4b\u4e88\u671f\u6743\u4ef7\u503c\uff1a\u7528\u4e8e\u82ac\u592a\u5c3c\u76f8\u5173\u547c\u5438\u6291\u5236\u7684\u4e34\u5e8a\u62a4\u7406\uff0c\u4ee5\u53ca\u751f\u7269\u9632\u5fa1\u91c7\u8d2d\u3002\u524d\u8005\u7ade\u4e89\u6fc0\u70c8\u4f46\u89c4\u6a21\u5e9e\u5927\u4e14\u6301\u7eed\uff1b\u540e\u8005\u5219\u4e0d\u7a33\u5b9a\u4f46\u53ef\u80fd\u5229\u6da6\u4e30\u539a\uff0c\u5177\u6709\u591a\u5e74\u91c7\u8d2d\u534f\u8bae\uff0c\u53ef\u4ee5\u5e73\u6ed1\u6536\u5165\u5e76\u964d\u4f4e\u5236\u9020\u89c4\u6a21\u5316\u7684\u98ce\u9669\u3002\u95ee\u9898\u5728\u4e8e\u6267\u884c\u3002\u751f\u7269\u79d1\u6280\u6b63\u5904\u4e8e\u98ce\u9669\u504f\u597d\u9636\u6bb5\uff0c\u5e26\u6709\u6311\u8845\u6027\u7684\u8d44\u4ea7\u5728\u5efa\u6a21\u6570\u636e\u53d1\u5e03\u540e\u53ef\u4ee5\u4e3a\u5e02\u503c\u589e\u52a0\u6570\u5343\u4e07\u6216\u6570\u4ebf\u7f8e\u5143\uff1b\u5f53\u65f6\u95f4\u8868\u5ef6\u8fdf\u6216\u4e0b\u4e00\u4e2a\u6570\u636e\u96c6\u8868\u73b0\u6df7\u4e71\u65f6\uff0c\u56de\u843d\u4fbf\u4f1a\u5230\u6765\u3002\u8fd9\u91cc\u7684\u4e8b\u5b9e\u6a21\u5f0f\u2014\u20148 \u6708 13 \u65e5\u7684\u77e5\u8bc6\u4ea7\u6743\u80dc\u5229\u3001\u660e\u786e\u7684\u516c\u5171\u536b\u751f\u4f7f\u7528\u6848\u4f8b\u4ee5\u53ca\u6697\u793a\u5dee\u5f02\u5316\u7684\u6a21\u62df\u2014\u2014\u4e3a\u91cd\u65b0\u5b9a\u4ef7\u63d0\u4f9b\u4e86\u7406\u7531\u3002\u91cd\u65b0\u5b9a\u4ef7\u662f\u5426\u80fd\u6301\u7eed\uff0c\u53d6\u51b3\u4e8e\u7ba1\u7406\u5c42\u5c06\u6a21\u62df\u8f6c\u5316\u4e3a\u76d1\u7ba1\u7ea7\u522b\u6570\u636e\u7684\u80fd\u529b\u3002<\/p>\n
\u76d1\u7ba1\u8def\u5f84\u4e0e Animal Rule \u7684\u95ee\u9898\uff1a \u963f\u7247\u7c7b\u9006\u8f6c\u5242\u6709\u660e\u786e\u7684 FDA \u8def\u5f84\uff0c\u5728\u53d7\u63a7\u73af\u5883\u4e0b\u53ef\u884c\u7684\u4eba\u4f53\u6311\u6218\u7814\u7a76\u4e5f\u662f\u53ef\u884c\u7684\u3002\u8fd9\u8868\u660e TH-104 \u4e0d\u5fc5\u4f9d\u8d56 FDA \u7684 Animal Rule\uff0c\u90a3\u662f\u9488\u5bf9\u4e0d\u80fd\u5728\u4eba\u4f53\u8fdb\u884c\u4f26\u7406\u6d4b\u8bd5\u7684\u751f\u7269\u9632\u5fa1\u4ea7\u54c1\u7684\u4e00\u79cd\u673a\u5236\u3002\u4e0d\u8fc7\uff0c\u56fd\u5bb6\u5b89\u5168\u5b9a\u4f4d\u6253\u5f00\u4e86\u5e73\u884c\u5de5\u4f5c\u6d41\u7684\u5927\u95e8\uff1a\u4e00\u65b9\u9762\u4e3a\u533b\u7597\u7528\u9014\u8fdb\u884c\u4e34\u5e8a\u5f00\u53d1\uff0c\u53e6\u4e00\u65b9\u9762\u8fdb\u884c\u65e8\u5728\u5927\u89c4\u6a21\u66b4\u9732\u51c6\u5907\u7684\u653f\u5e9c\u652f\u6301\u7814\u7a76\u3002\u8fd1\u671f\u5173\u952e\u91cc\u7a0b\u7891\u662f\u5177\u4f53\u7684\uff1a\u76ee\u6807\u4ea7\u54c1\u7279\u5f81\u3001\u6765\u81ea FDA \u7684 IND \u524d\u53cd\u9988\u3001\u80fd\u660e\u786e\u8d77\u6548\u65f6\u95f4\u548c\u6301\u7eed\u65f6\u95f4\u5e76\u4e0e\u7eb3\u6d1b\u916e\u53ca\u7eb3\u7f8e\u82ac\u6bd4\u8f83\u7684\u836f\u7406\u5b66\u6570\u636e\uff0c\u4ee5\u53ca\u9996\u6b21\u4eba\u4f53\u8bd5\u9a8c\u7684\u65f6\u95f4\u8868\u3002\u6295\u8d44\u8005\u8fd8\u5e94\u5173\u6ce8\u5236\u9020\u65b9\u9762\u7684\u66f4\u65b0\uff1b\u5728\u5bf9\u6297\u63aa\u65bd\u60c5\u666f\u4e0b\uff0c\u7a33\u5b9a\u4f9b\u5e94\u548c\u8d27\u67b6\u671f\u4e0e\u7597\u6548\u4e00\u6837\u91cd\u8981\u3002<\/p>\n
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