{"id":611619,"date":"2025-12-24T04:59:30","date_gmt":"2025-12-24T12:59:30","guid":{"rendered":"https:\/\/nai500.com\/?p=611619"},"modified":"2025-12-24T04:59:30","modified_gmt":"2025-12-24T12:59:30","slug":"sanofi-sny-22-dynavax-dvax","status":"publish","type":"post","link":"https:\/\/nai500.com\/zh-hans\/blog\/2025\/12\/sanofi-sny-22-dynavax-dvax\/","title":{"rendered":"Sanofi SNY \u4ee5 22 \u4ebf\u7f8e\u5143\u6536\u8d2d Dynavax DVAX\uff0c\u8f6c\u5411\u75ab\u82d7\u4e1a\u52a1"},"content":{"rendered":"

Sanofi \u901a\u8fc7\u4e00\u9879\u4ef7\u503c 22 \u4ebf\u7f8e\u5143\u7684\u6536\u8d2d\u4ea4\u6613\u6536\u7d27\u5176\u75ab\u82d7\u4e1a\u52a1\uff0c\u4ee5\u73b0\u91d1\u6bcf\u80a1 15.50 \u7f8e\u5143\u6536\u8d2d Dynavax Technologies\uff0c\u6b64\u62a5\u4ef7\u8f83\u5468\u4e00\u6536\u76d8\u4ef7\u6ea2\u4ef7 39%\u3002\u6b64\u6b21\u8981\u7ea6\u53d1\u751f\u5728 FDA \u5bf9 Sanofi \u7684\u591a\u53d1\u6027\u786c\u5316\u5019\u9009\u836f\u7269 tolebrutinib \u53d1\u51fa\u5b8c\u6574\u56de\u5e94\u4fe1\uff08complete response letter\uff09\u6570\u65e5\u4e4b\u540e\uff0c\u8fd9\u4e00\u632b\u6298\u4f7f\u4eba\u4eec\u66f4\u52a0\u5173\u6ce8\u7a33\u5b9a\u589e\u957f\u7684\u4e1a\u52a1\u7ebf\u3002\u5728\u6d41\u52a8\u6027\u7a00\u8584\u7684\u5047\u671f\u4ea4\u6613\u4e2d\uff0cSanofi \u80a1\u4ef7\u5c0f\u5e45\u4e0a\u6da8\uff0c\u800c Dynavax \u80a1\u4ef7\u4f4e\u4e8e\u8981\u7ea6\u4ef7\uff0c\u51f8\u663e\u51fa\u6295\u8d44\u8005\u5bf9\u6210\u4ea4\u65f6\u673a\u548c\u6267\u884c\u7684\u8c28\u614e\u6001\u5ea6\u3002Sanofi \u8868\u793a\u6b64\u6b21\u6536\u8d2d\u4e0d\u4f1a\u6539\u53d8\u5176 2025 \u5e74\u6307\u5f15\uff0c\u5e76\u5c06\u4ee5\u73b0\u6709\u73b0\u91d1\u652f\u4ed8\u3002<\/p>\n

\u4ea4\u6613\u6761\u6b3e\u4e0e\u4f30\u503c<\/h3>\n

\u8be5\u4ea4\u6613\u7ed3\u6784\u4e3a\u5bf9 Dynavax \u53d1\u8d77\u5168\u90e8\u73b0\u91d1\u8981\u7ea6\uff0c\u4ef7\u683c\u4e3a\u6bcf\u80a1 15.50 \u7f8e\u5143\uff0c\u968f\u540e\u901a\u8fc7\u5408\u5e76\u6536\u8d2d\u5269\u4f59\u80a1\u4efd\u3002\u6b64\u6b21\u6ea2\u4ef7\u6709\u52a9\u4e8e\u5b9e\u73b0\u591a\u6570\u80a1\u4efd\u7684\u6295\u6807\uff0c\u76ee\u6807\u4e8e 2026 \u5e74\u7b2c\u4e00\u5b63\u5ea6\u5b8c\u6210\u4ea4\u5272\uff0c\u987b\u6ee1\u8db3\u5e38\u89c4\u6761\u4ef6\u5e76\u53d6\u5f97\u76d1\u7ba1\u6279\u51c6\u3002\u6309\u6807\u4ef7\u8ba1\u7b97\uff0cSanofi \u4e3a\u5df2\u4e0a\u5e02\u8d44\u4ea7 HEPLISAV-B\uff08\u4e00\u79cd\u6210\u4eba\u4e59\u578b\u809d\u708e\u75ab\u82d7\uff09\u652f\u4ed8\u6ea2\u4ef7\uff0c\u540c\u65f6\u8fd8\u83b7\u5f97\u4e00\u4e2a\u5904\u4e8e\u65e9\u671f\u7684\u5e26\u72b6\u75b1\u75b9\u5019\u9009\u548c\u4e00\u5957\u7ecf\u9a8c\u8bc1\u7684\u4f50\u5242\u5e73\u53f0\u3002\u5bf9 Sanofi \u6765\u8bf4\uff0c\u8fd9\u7b14\u4ea4\u6613\u7684\u8ba1\u7b97\u66f4\u591a\u662f\u5173\u4e8e\u5728\u6210\u4eba\u514d\u75ab\u9886\u57df\u7684\u6218\u7565\u5951\u5408\uff0c\u800c\u975e\u77ed\u671f\u6536\u76ca\u8d21\u732e\uff0c\u56e0\u4e3a\u5176\u5728\u8be5\u9886\u57df\u5df2\u6709\u89c4\u6a21\u4e0e\u5206\u9500\u7f51\u7edc\u3002\u516c\u53f8\u672a\u8c03\u6574\u6307\u5f15\uff0c\u8868\u660e\u660e\u5e74\u8d2d\u5e76\u4f1a\u8ba1\u4e0e\u6574\u5408\u8d39\u7528\u5e26\u6765\u7684\u8d22\u52a1\u62d6\u7d2f\u662f\u53ef\u7ba1\u7406\u7684\u3002<\/p>\n

\u5728\u6210\u4eba\u514d\u75ab\u9886\u57df\u7684\u6218\u7565\u5951\u5408<\/h3>\n

Dynavax \u5e26\u6765\u4e86 HEPLISAV-B\uff0c\u8fd9\u662f\u4e00\u79cd\u5dee\u5f02\u5316\u7684\u4e24\u5242\u75ab\u82d7\uff0c\u53ef\u4e0e\u4f20\u7edf\u7684\u4e09\u5242\u65b9\u6848\u7ade\u4e89\uff0c\u5e76\u62e5\u6709\u4ee5 CpG 1018 \u4f50\u5242\u6280\u672f\u4e3a\u57fa\u7840\u7684\u5e26\u72b6\u75b1\u75b9\u9879\u76ee\u3002\u7f8e\u56fd\u75be\u75c5\u63a7\u5236\u4e0e\u9884\u9632\u4e2d\u5fc3\u5728 2022 \u5e74\u6269\u5927\u4e86\u6210\u4eba\u4e59\u578b\u809d\u708e\u75ab\u82d7\u5efa\u8bae\uff0c\u6269\u5927\u4e86\u9002\u7528\u4eba\u7fa4\u5e76\u63d0\u5347\u4e86\u9700\u6c42\u987a\u98ce\uff0cHEPLISAV-B \u5df2\u901a\u8fc7\u836f\u623f\u3001\u533b\u7597\u7cfb\u7edf\u548c\u96c7\u4e3b\u8bca\u6240\u5e03\u5c40\u4ee5\u4e89\u53d6\u8fd9\u4e9b\u9700\u6c42\u3002Sanofi \u7684\u75ab\u82d7\u5f15\u64ce\u4ee5\u6d41\u611f\u548c\u513f\u7ae5\u75ab\u82d7\u7ec4\u5408\u4e3a\u6838\u5fc3\uff0c\u4e14\u5728\u836f\u623f\u548c\u533b\u751f\u529e\u516c\u5ba4\u62e5\u6709\u5e7f\u6cdb\u5546\u4e1a\u8db3\u8ff9\u3002\u65b0\u589e\u4e00\u79cd\u5546\u4e1a\u5316\u6210\u4eba\u4e59\u809d\u75ab\u82d7\u548c\u5e26\u72b6\u75b1\u75b9\u5019\u9009\u53ef\u5c06\u5176\u8986\u76d6\u8303\u56f4\u5ef6\u4f38\u5230\u4e24\u5927\u9ad8\u4f7f\u7528\u7387\u7684\u6210\u4eba\u7c7b\u522b\u3002\u6b63\u5982 Sanofi \u75ab\u82d7\u4e1a\u52a1\u8d1f\u8d23\u4eba Thomas Triomphe \u6240\u8a00\uff0cDynavax \u7684\u75ab\u82d7\u8865\u5145\u4e86 Sanofi \u7684\u4e13\u957f\u3002\u5728 tolebrutinib \u53d7\u5230\u632b\u6298\u7684\u80cc\u666f\u4e0b\uff0c\u6b64\u4e3e\u663e\u793a\u516c\u53f8\u7406\u6027\u5730\u8f6c\u5411\u4e00\u4e2a\u5177\u6709\u53ef\u89c1\u3001\u653f\u7b56\u652f\u6301\u9700\u6c42\u7684\u751f\u7269\u5236\u836f\u7ec6\u5206\u9886\u57df\u3002<\/p>\n

\u5e02\u573a\u53cd\u5e94\u4e0e\u5957\u5229\u4ef7\u5dee<\/h3>\n

\u5373\u65f6\u5e02\u573a\u53cd\u5e94\u504f\u8c28\u614e\u3002Sanofi \u7565\u6709\u4e0a\u626c\uff0c\u53cd\u6620\u51fa\u5e02\u573a\u5bf9\u5b9a\u4ef7\u53ca\u6218\u7565\u903b\u8f91\u7684\u8ba4\u53ef\u3002\u7136\u800c Dynavax \u80a1\u4ef7\u8fdc\u4f4e\u4e8e\u8981\u7ea6\u4ef7\uff0c\u7559\u4e0b\u4e86\u8f83\u5927\u7684\u5e76\u8d2d\u5957\u5229\u4ef7\u5dee\uff0c\u5bf9\u4e8e\u4e00\u6869\u91cd\u53e0\u8f83\u4f4e\u7684\u4ea4\u6613\u800c\u8a00\u8fd9\u5e76\u4e0d\u7f55\u89c1\u3002\u90e8\u5206\u5dee\u8ddd\u53ef\u5f52\u56e0\u4e8e\u5047\u671f\u671f\u95f4\u7684\u6d41\u52a8\u6027\u4e0d\u8db3\u4ee5\u53ca\u5230 2026 \u5e74\u7b2c\u4e00\u5b63\u5ea6\u8f83\u957f\u7684\u4ea4\u5272\u65f6\u95f4\uff0c\u8fd9\u4f1a\u62ac\u9ad8\u5957\u5229\u6536\u76ca\u4e2d\u6240\u9690\u542b\u7684\u65f6\u95f4\u4ef7\u503c\u3002\u8be5\u4ef7\u5dee\u4e5f\u53ef\u80fd\u53cd\u6620\u51fa\u5e38\u89c4\u7684\u76d1\u7ba1\u4e0d\u786e\u5b9a\u6027\u548c\u8981\u7ea6\u95e8\u69db\u3002\u5c06\u6d41\u611f\u4e0e\u6210\u4eba\u4e59\u809d\u7684\u5206\u9500\u4e0e\u5355\u4e00\u8d44\u4ea7\u751f\u7269\u6280\u672f\u516c\u53f8\u5408\u5e76\uff0c\u660e\u663e\u7684\u53cd\u5784\u65ad\u6469\u64e6\u4e0d\u591a\uff0c\u4f46\u5728\u7ecf\u5386\u4e86\u533b\u7597\u5065\u5eb7\u5e76\u8d2d\u5e02\u573a\u7684\u8270\u96be\u4e00\u5e74\u540e\uff0c\u6295\u8d44\u8005\u5df2\u7ecf\u5b66\u4f1a\u4e0d\u628a\u4e00\u5207\u89c6\u4e3a\u6ce8\u5b9a\u6210\u529f\u3002\u5e02\u573a\u5728\u8981\u6c42 Sanofi \u5e72\u51c0\u5229\u843d\u5730\u6267\u884c\uff0c\u907f\u514d\u5728\u8d28\u91cf\u3001\u4f9b\u5e94\u6216\u6807\u7b7e\u65b9\u9762\u51fa\u73b0\u4ee4\u4eba\u610f\u5916\u7684\u95ee\u9898\u3002<\/p>\n

\u5e26\u72b6\u75b1\u75b9\u4e4b\u4e89\u4e0e\u7ade\u4e89\u683c\u5c40<\/h3>\n

\u5e26\u72b6\u75b1\u75b9\u662f\u9664\u6d41\u611f\u4e4b\u5916\u6700\u5927\u7684\u6210\u4eba\u75ab\u82d7\u5546\u673a\u3002GSK \u7684 Shingrix \u5360\u636e\u4e3b\u5bfc\u5730\u4f4d\uff0c\u5e74\u9500\u552e\u989d\u6570\u5341\u4ebf\u7f8e\u5143\uff0c\u51ed\u501f\u826f\u597d\u7684\u7597\u6548\u4e0e\u79ef\u6781\u7684\u5168\u7403\u63a8\u5e7f\u5efa\u7acb\u4e86\u5730\u4f4d\u3002Sanofi \u5b9e\u9645\u4e0a\u6bd4\u8bb8\u591a\u4eba\u9884\u671f\u5f97\u66f4\u65e9\u4e70\u5165\u4e86\u8fdb\u5165\u8fd9\u573a\u7ade\u4e89\u7684\u95e8\u7968\uff0cDynavax \u7684 Z-1018 \u6b63\u5904\u4e8e I\/II \u671f\u5f00\u53d1\u3002\u65e9\u671f\u9879\u76ee\u98ce\u9669\u8f83\u5927\uff0c\u4f46\u6218\u7565\u7406\u7531\u660e\u786e\uff1aSanofi \u64c5\u957f\u5728\u89c4\u6a21\u4e0a\u6784\u5efa\u6210\u4eba\u75ab\u82d7\u4e1a\u52a1\uff0c\u82e5\u6b64\u9879\u76ee\u6210\u529f\uff0c\u5c06\u6709\u52a9\u4e8e\u4ece\u5b63\u8282\u6027\u6d41\u611f\u4e2d\u5206\u6563\u98ce\u9669\u5e76\u589e\u6dfb\u6301\u7eed\u589e\u957f\u52a8\u529b\u3002\u5728\u4e59\u809d\u65b9\u9762\uff0cHEPLISAV-B \u4e3b\u8981\u4e0e GSK \u548c Merck \u7684\u957f\u671f\u4ea7\u54c1\u7ade\u4e89\u3002\u5176\u5728\u4e00\u4e2a\u6708\u5185\u5b8c\u6210\u4e24\u5242\u7684\u63a5\u79cd\u65b9\u6848\uff0c\u5728\u4f9d\u4ece\u6027\u548c\u804c\u4e1a\u5065\u5eb7\u9879\u76ee\u4e2d\u5177\u6709\u5dee\u5f02\u5316\u4f18\u52bf\u3002\u968f\u7740\u6210\u4eba\u63a5\u79cd\u5efa\u8bae\u7684\u6269\u5927\uff0c\u836f\u623f\u4e2d\u7684\u91c7\u7528\u7387\u5728\u4e0a\u5347\uff0cSanofi \u7684\u5546\u4e1a\u80fd\u529b\u53ef\u4ee5\u52a0\u901f\u4efd\u989d\u589e\u957f\u3002\u8be5\u8d4c\u6ce8\u662f\uff1a\u66f4\u5927\u7684\u5916\u52e4\u961f\u4f0d\u548c\u4ed8\u6b3e\u65b9\u5408\u7ea6\u80fd\u529b\u80fd\u591f\u653e\u5927\u8fd9\u4e00\u8d8b\u52bf\u3002<\/p>\n

\u5e73\u53f0\u4e0e\u5236\u9020\u534f\u540c<\/h3>\n

\u9664\u6807\u7684\u4ea7\u54c1\u5916\uff0cDynavax \u7684 CpG 1018 \u4f50\u5242\u4e3a Sanofi \u63d0\u4f9b\u4e86\u53ef\u9009\u6027\u3002\u4f50\u5242\u5bf9\u57fa\u4e8e\u86cb\u767d\u7684\u75ab\u82d7\u7684\u514d\u75ab\u539f\u6027\u548c\u8282\u7701\u5242\u91cf\u81f3\u5173\u91cd\u8981\uff0c\u8be5\u5e73\u53f0\u5df2\u5546\u4e1a\u5316\u5e94\u7528\u4e8e HEPLISAV-B\uff0c\u5e76\u5728\u75ab\u60c5\u671f\u95f4\u5e7f\u6cdb\u4e3a\u5408\u4f5c\u4f19\u4f34\u75ab\u82d7\u4f9b\u8d27\u4ee5\u589e\u5f3a\u6548\u4ef7\u3002Sanofi \u5728\u4f50\u5242\u86cb\u767d\u75ab\u82d7\u65b9\u9762\u7684\u5386\u53f2\u53ca\u5176\u5168\u7403\u5236\u9020\u7f51\u7edc\u8868\u660e\u5b58\u5728\u5b9e\u9645\u7684\u6574\u5408\u8def\u5f84\u3002\u5176\u53ef\u5229\u7528\u8d28\u91cf\u4f53\u7cfb\u3001\u704c\u88c5\u4e0e\u5b8c\u6210\uff08fill-finish\uff09\u4ea7\u80fd\u548c\u91c7\u8d2d\u89c4\u6a21\u6765\u964d\u4f4e\u5355\u4f4d\u6210\u672c\u5e76\u7a33\u5b9a\u4f9b\u5e94\u3002\u516c\u53f8\u5728\u65e9\u671f\u5df2\u5728\u4e0e\u5916\u90e8\u5408\u4f5c\u4f19\u4f34\u7684 mRNA \u8ba1\u5212\u4e0a\u8c03\u6574\u6218\u7565\uff0c\u63a8\u52a8\u75ab\u82d7\u7ba1\u7ebf\u7684\u4f18\u5316\u3002\u62e5\u6709\u4e00\u9879\u5df2\u9a8c\u8bc1\u7684\u4f50\u5242\u6280\u672f\uff0c\u7ed9 Sanofi \u63d0\u4f9b\u4e86\u5185\u90e8\u6760\u6746\u4ee5\u8fed\u4ee3\u6297\u539f\u3001\u63d0\u9ad8\u514d\u75ab\u539f\u6027\uff0c\u5e76\u53ef\u80fd\u5728\u591a\u4e2a\u9879\u76ee\u4e0a\u5ef6\u957f\u751f\u547d\u5468\u671f\u3002\u8fd9\u79cd\u5e73\u53f0\u903b\u8f91\uff0c\u800c\u4e0d\u4ec5\u4ec5\u662f HEPLISAV-B \u7684\u6536\u5165\u7ebf\uff0c\u5e2e\u52a9\u5408\u7406\u5316\u4e86\u6536\u8d2d\u4ef7\u683c\u3002<\/p>\n

\u76d1\u7ba1\u4e0e\u4ea4\u5272\u65f6\u95f4\u8868<\/h3>\n

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