{"id":649117,"date":"2026-07-08T18:38:55","date_gmt":"2026-07-09T01:38:55","guid":{"rendered":"https:\/\/nai500.com\/?p=649117"},"modified":"2026-07-08T18:38:55","modified_gmt":"2026-07-09T01:38:55","slug":"%e9%ab%98%e6%ba%a2%e4%bb%b7%e6%94%b6%e8%b4%ad-crinetics-%e8%82%a1%e4%bb%b7%e5%88%9b%e6%96%b0%e9%ab%98%ef%bc%8cvertex-%e8%bf%98%e8%83%bd%e4%b9%b0%e5%90%97%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/nai500.com\/zh-hans\/blog\/2026\/07\/%e9%ab%98%e6%ba%a2%e4%bb%b7%e6%94%b6%e8%b4%ad-crinetics-%e8%82%a1%e4%bb%b7%e5%88%9b%e6%96%b0%e9%ab%98%ef%bc%8cvertex-%e8%bf%98%e8%83%bd%e4%b9%b0%e5%90%97%ef%bc%9f\/","title":{"rendered":"\u9ad8\u6ea2\u4ef7\u6536\u8d2d Crinetics + \u80a1\u4ef7\u521b\u65b0\u9ad8\uff0cVertex \u8fd8\u80fd\u4e70\u5417\uff1f"},"content":{"rendered":"

\u6700\u8fd1\uff0c\u5168\u7403\u7f55\u89c1\u75c5\u836f\u4f01\u9f99\u5934 Vertex Pharmaceuticals\uff08VRTX\uff09<\/a>\u5ba3\u5e03\u4ee5\u5168\u73b0\u91d1\u65b9\u5f0f\u6536\u8d2d\u5185\u5206\u6ccc\u836f\u4f01 Crinetics Pharmaceuticals\uff08CRNX\uff09<\/a>\uff0c\u4ea4\u6613\u603b\u80a1\u6743\u4ef7\u503c\u8fbe 100 \u4ebf\u7f8e\u5143\uff0c\u6ea2\u4ef7\u5e45\u5ea6\u63a5\u8fd1\u7ffb\u500d\u3002\u5c31\u5728\u5e76\u8d2d\u6d88\u606f\u843d\u5730\u524d\u540e\uff0cVertex \u80a1\u4ef7\u521a\u521a\u521b\u4e0b 533.67 \u7f8e\u5143\u7684\u5386\u53f2\u65b0\u9ad8\uff0c\u5e74\u5185\u7d2f\u8ba1\u6da8\u5e45\u8fd1 17%\uff0c\u5927\u5e45\u8dd1\u8d62\u6807\u666e 500 \u6307\u6570\u3002<\/p>\n

\u4e00\u8fb9\u662f\u5927\u624b\u7b14\u5e76\u8d2d\u62d3\u5bbd\u7ba1\u7ebf\u8fb9\u754c\uff0c\u4e00\u8fb9\u662f\u80a1\u4ef7\u9ad8\u4f4d\u3001\u4f30\u503c\u62ac\u5347\uff0c\u5f53\u4e0b\u7684 Vertex \u7a76\u7adf\u662f\u52a0\u4ed3\u826f\u673a\u8fd8\u662f\u4f30\u503c\u89c1\u9876\uff1f<\/p>\n

\u767e\u4ebf\u6ea2\u4ef7\u5e76\u8d2d\uff0c\u8865\u9f50\u5185\u5206\u6ccc\u53cc\u91cd\u78c5\u7ba1\u7ebf<\/h2>\n

\u6839\u636e\u53cc\u65b9\u8054\u5408\u516c\u544a\uff0cVertex \u5c06\u4ee5\u6bcf\u80a1 85 \u7f8e\u5143\u5168\u73b0\u91d1\u6536\u8d2d Crinetics \u5168\u90e8\u80a1\u4efd\uff0c\u5bf9\u5e94\u603b\u80a1\u6743\u4ef7\u503c\u7ea6 100 \u4ebf\u7f8e\u5143\uff0c\u6263\u9664 Crinetics \u8d26\u9762\u73b0\u91d1\u53ca\u77ed\u671f\u6295\u8d44\u540e\uff0c\u51c0\u4ea4\u6613\u5bf9\u4ef7\u7ea6 88 \u4ebf\u7f8e\u5143\u3002\u8be5\u4ef7\u683c\u8f83\u6d88\u606f\u516c\u5e03\u524d\u6536\u76d8\u4ef7\u6ea2\u4ef7\u8fd1 100%\uff0c\u4ea4\u6613\u5df2\u83b7\u53cc\u65b9\u8463\u4e8b\u4f1a\u4e00\u81f4\u6279\u51c6\uff0c\u9884\u8ba1 2026 \u5e74\u7b2c\u4e09\u5b63\u5ea6\u5b8c\u6210\u4ea4\u5272\u3002<\/p>\n

\u8fd9\u7b14\u6536\u8d2d\u7684\u6838\u5fc3\u4ef7\u503c\u5728\u4e8e\u4e24\u6b3e\u91cd\u78c5\u7ea7\u5185\u5206\u6ccc\u836f\u7269\u8d44\u4ea7\u3002\u5176\u4e00\u4e3a\u5df2\u4e0a\u5e02\u4ea7\u54c1 Palsonify\uff0c\u662f\u5168\u7403\u9996\u6b3e\u4e14\u552f\u4e00\u4e00\u6b3e\u6bcf\u65e5\u53e3\u670d\u4e00\u6b21\u7684\u6210\u4eba\u80a2\u7aef\u80a5\u5927\u75c7\u6cbb\u7597\u836f\u7269\uff0c2025 \u5e74 9 \u6708\u83b7 FDA \u6279\u51c6\u30012026 \u5e74 4 \u6708\u62ff\u4e0b\u6b27\u76df\u4e0a\u5e02\u8bb8\u53ef\uff0c\u4e0a\u5e02\u9996\u4e2a\u5b8c\u6574\u5b63\u5ea6\u5373\u5b9e\u73b0 1070 \u4e07\u7f8e\u5143\u8425\u6536\uff0c\u51ed\u501f\u53e3\u670d\u5242\u578b\u4f18\u52bf\u5feb\u901f\u66ff\u4ee3\u539f\u6709\u6ce8\u5c04\u5242\u5e02\u573a\u3002<\/p>\n

\u5176\u4e8c\u4e3a\u6838\u5fc3\u5728\u7814\u7ba1\u7ebf atumelnant\uff0c\u9488\u5bf9\u5148\u5929\u6027\u80be\u4e0a\u817a\u589e\u751f\uff08CAH\uff09\u5df2\u5904\u4e8e III \u671f\u4e34\u5e8a\u540e\u671f\uff0c\u540c\u65f6\u5177\u5907\u62d3\u5c55\u5e93\u6b23\u7efc\u5408\u5f81\u9002\u5e94\u75c7\u7684\u6f5c\u529b\u3002\u673a\u6784\u9884\u8ba1\uff0c\u82e5\u53cc\u9002\u5e94\u75c7\u5747\u6210\u529f\u83b7\u6279\uff0cPalsonify \u4e0e atumelnant \u5408\u8ba1\u5e74\u9500\u552e\u5cf0\u503c\u6709\u671b\u7a81\u7834 50 \u4ebf\u7f8e\u5143\uff0c\u6210\u4e3a Vertex \u56ca\u6027\u7ea4\u7ef4\u5316\u4e4b\u5916\u7684\u5168\u65b0\u589e\u957f\u66f2\u7ebf\u3002<\/p>\n

Vertex \u9996\u5e2d\u6267\u884c\u5b98 Reshma Kewalramani \u8868\u793a\uff0c\u516c\u53f8\u5c06\u4f9d\u6258\u81ea\u8eab\u5728\u7f55\u89c1\u75c5\u9886\u57df\u7684\u5546\u4e1a\u5316\u7ecf\u9a8c\u52a0\u901f Palsonify \u7684\u5168\u7403\u653e\u91cf\uff0c\u5e76\u63a8\u52a8 atumelnant \u5c3d\u5feb\u843d\u5730\u3002\u8d44\u91d1\u5c42\u9762\uff0cVertex \u4e00\u5b63\u5ea6\u672b\u624b\u63e1\u8d85 55 \u4ebf\u7f8e\u5143\u73b0\u91d1\uff0c\u540c\u65f6\u5df2\u83b7\u5f97\u7f8e\u94f6\u3001\u6469\u6839\u58eb\u4e39\u5229\u63d0\u4f9b\u7684 45 \u4ebf\u7f8e\u5143\u8fc7\u6865\u8d37\u6b3e\uff0c\u5168\u989d\u8986\u76d6\u6536\u8d2d\u5bf9\u4ef7\uff0c\u8d22\u52a1\u98ce\u9669\u53ef\u63a7\u3002<\/p>\n

\u80a1\u4ef7\u521b\u5386\u53f2\u65b0\u9ad8\uff0c\u65b0\u65e7\u589e\u957f\u52a8\u80fd\u5207\u6362<\/h2>\n

\u4f5c\u4e3a\u56ca\u6027\u7ea4\u7ef4\u5316\u6cbb\u7597\u9886\u57df\u7684\u7edd\u5bf9\u9f99\u5934\uff0cVertex \u662f\u4eca\u5e74\u7f8e\u80a1\u533b\u836f\u677f\u5757\u7684\u6838\u5fc3\u5f3a\u52bf\u6807\u7684\u3002\u622a\u81f3 7 \u6708 7 \u65e5\u6536\u76d8\uff0c\u516c\u53f8\u80a1\u4ef7\u62a5 522.25 \u7f8e\u5143\uff0c\u603b\u5e02\u503c\u8fbe 1325.5 \u4ebf\u7f8e\u5143\uff0c\u76d8\u4e2d\u6700\u9ad8\u89e6\u53ca 533.67 \u7f8e\u5143\u7684\u5386\u53f2\u65b0\u9ad8\uff0c\u5e74\u5185\u7d2f\u8ba1\u6da8\u5e45\u7ea6 17%\uff0c\u663e\u8457\u8dd1\u8d62\u6807\u666e 500 \u540c\u671f\u7ea6 10% \u7684\u8868\u73b0\u3002<\/p>\n

\u80a1\u4ef7\u8d70\u5f3a\u7684\u5e95\u5c42\u903b\u8f91\uff0c\u662f\u5e02\u573a\u5bf9\u5176\u7b2c\u4e8c\u589e\u957f\u66f2\u7ebf\u7684\u9884\u671f\u6b63\u5728\u5347\u6e29\u3002\u8fd1\u5e74\u6765\uff0c\u516c\u53f8\u6838\u5fc3\u56ca\u6027\u7ea4\u7ef4\u5316\u4e1a\u52a1\u589e\u901f\u9010\u6b65\u56de\u843d\uff0c2026 \u5e74\u4e00\u5b63\u5ea6\u8425\u6536\u540c\u6bd4\u4ec5\u589e\u957f 8.3% \u81f3 29.9 \u4ebf\u7f8e\u5143\uff0c\u4f20\u7edf\u4e1a\u52a1\u8fdb\u5165\u5e73\u7a33\u671f\u3002\u800c\u5f53\u524d\u5e02\u573a\u7684\u589e\u957f\u4fe1\u5fc3\uff0c\u4e3b\u8981\u6765\u81ea\u4e09\u5927\u589e\u91cf\uff1a<\/p>\n

    \n
  • \u57fa\u56e0\u7597\u6cd5 Casgevy \u5904\u4e8e\u4e0a\u5e02\u521d\u671f\uff0c\u5168\u7403\u5546\u4e1a\u5316\u653e\u91cf\u4ecd\u5728\u722c\u5761\uff1b<\/li>\n
  • \u975e\u963f\u7247\u7c7b\u6b62\u75db\u836f Journavx \u83b7\u6279\u6ee1\u4e00\u5e74\uff0c\u5e02\u573a\u6e17\u900f\u6301\u7eed\u63d0\u5347\uff1b<\/li>\n
  • \u672c\u6b21\u6536\u8d2d\u843d\u5730\u540e\uff0c\u5185\u5206\u6ccc\u7ba1\u7ebf\u5c06\u76f4\u63a5\u8d21\u732e\u8425\u6536\u4e0e\u957f\u671f\u589e\u957f\u7a7a\u95f4\u3002<\/li>\n<\/ul>\n

    \u4ece\u673a\u6784\u6001\u5ea6\u6765\u770b\uff0c\u76ee\u524d\u534e\u5c14\u8857\u5206\u6790\u5e08\u5bf9 Vertex \u666e\u904d\u504f\u4e50\u89c2\uff0c21 \u5bb6\u673a\u6784\u7ed9\u51fa\u4e70\u5165\u8bc4\u7ea7\uff0c\u5e73\u5747\u76ee\u6807\u4ef7\u7ea6 557 \u7f8e\u5143\uff0c\u8f83\u5f53\u524d\u80a1\u4ef7\u4ecd\u6709\u8fd1 7% \u7684\u4e0a\u6da8\u7a7a\u95f4\u3002<\/p>\n

    \u4f30\u503c\u5904\u4e8e\u9ad8\u4f4d\uff0c\u77ed\u671f\u6027\u4ef7\u6bd4\u5b58\u7591<\/h2>\n

    \u5c3d\u7ba1\u57fa\u672c\u9762\u4e0e\u7ba1\u7ebf\u903b\u8f91\u624e\u5b9e\uff0c\u4f46\u7ad9\u5728\u5386\u53f2\u65b0\u9ad8\u7684\u80a1\u4ef7\u4f4d\u7f6e\uff0c\u4f30\u503c\u6c34\u5e73\u5df2\u6210\u4e3a\u6295\u8d44\u8005\u8fdb\u573a\u7684\u6838\u5fc3\u987e\u8651\u3002<\/p>\n

    \u622a\u81f3 7 \u6708 7 \u65e5\uff0cVertex \u6eda\u52a8\u5e02\u76c8\u7387\uff08TTM\uff09\u7ea6 31 \u500d\uff0c\u663e\u8457\u9ad8\u4e8e\u6807\u666e 500 \u5e73\u5747 25 \u500d\u7684\u4f30\u503c\u6c34\u5e73\uff0c\u4e5f\u9ad8\u4e8e\u751f\u7269\u5236\u836f\u884c\u4e1a\u5e73\u5747 21.9 \u500d\u7684\u8fdc\u671f\u5e02\u76c8\u7387\u3002\u66f4\u80fd\u53cd\u6620\u589e\u957f\u6027\u4ef7\u6bd4\u7684 PEG \u6307\u6807\u7ea6\u4e3a 2.01\uff0c\u8fdc\u9ad8\u4e8e 1.0 \u7684 \u201c\u5408\u7406\u4f30\u503c\u9608\u503c\u201d\uff0c\u4e5f\u9ad8\u51fa\u884c\u4e1a\u5e73\u5747 1.73 \u7684\u6c34\u5e73\u3002\u8fd9\u610f\u5473\u7740\u5f53\u524d\u80a1\u4ef7\u5df2\u7ecf\u63d0\u524d\u5b9a\u4ef7\u4e86\u672a\u6765\u4e94\u5e74\u7684\u4e1a\u7ee9\u589e\u957f\u9884\u671f\uff0c\u5373\u4fbf\u5e76\u8d2d\u5e26\u6765\u65b0\u589e\u91cf\uff0c\u4e5f\u53ef\u80fd\u88ab\u73b0\u6709\u9ad8\u4f30\u503c\u90e8\u5206\u6d88\u5316\u3002<\/p>\n

    \u9664\u6b64\u4e4b\u5916\uff0c\u8fd9\u7b14\u9ad8\u6ea2\u4ef7\u6536\u8d2d\u4ecd\u5b58\u4e0d\u786e\u5b9a\u6027\uff1aatumelnant \u5c1a\u672a\u5b8c\u6210 III \u671f\u4e34\u5e8a\uff0c\u5b58\u5728\u7814\u53d1\u5931\u8d25\u6216\u6570\u636e\u4e0d\u53ca\u9884\u671f\u7684\u98ce\u9669\uff1bPalsonify \u4f5c\u4e3a\u7f55\u89c1\u75c5\u836f\u7269\uff0c\u60a3\u8005\u7fa4\u4f53\u89c4\u6a21\u6709\u9650\uff0c\u653e\u91cf\u901f\u5ea6\u80fd\u5426\u8fbe\u5230\u5e02\u573a\u9884\u671f\u4ecd\u5f85\u9a8c\u8bc1\uff1b\u540c\u65f6\u767e\u4ebf\u7ea7\u5e76\u8d2d\u540e\u7684\u56e2\u961f\u4e0e\u7ba1\u7ebf\u6574\u5408\uff0c\u4e5f\u53ef\u80fd\u5f71\u54cd\u6700\u7ec8\u6536\u76ca\u5151\u73b0\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

    \u6700\u8fd1\uff0c\u5168\u7403\u7f55\u89c1\u75c5\u836f\u4f01\u9f99\u5934 Vertex Pharmaceuticals\uff08VRTX\uff09\u5ba3\u5e03\u4ee5\u5168\u73b0\u91d1\u65b9\u5f0f\u6536\u8d2d\u5185\u5206\u6ccc\u836f […]<\/p>\n","protected":false},"author":27,"featured_media":485313,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[1521,430],"tags":[455,747,766,459],"class_list":["post-649117","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-1521","category-trends-strategies-zh-hans","tag-455","tag-747","tag-766","tag-459","sectors-life-science-zh-hans","locations-us-zh-hans","exchange-nasdaq-zh-hans"],"acf":[],"_links":{"self":[{"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/posts\/649117","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/users\/27"}],"replies":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/comments?post=649117"}],"version-history":[{"count":3,"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/posts\/649117\/revisions"}],"predecessor-version":[{"id":649120,"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/posts\/649117\/revisions\/649120"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/media\/485313"}],"wp:attachment":[{"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/media?parent=649117"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/categories?post=649117"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nai500.com\/zh-hans\/wp-json\/wp\/v2\/tags?post=649117"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}