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HotSpot \u516c\u53f8\u958b\u767c\u4e86\u5c08\u6709\u7684SpotFinder\u2122\u6280\u8853\u5e73\u81fa\uff0c\u80fd\u5920\u7cfb\u7d71\u6027\u5730\u767c\u73fe\u548c\u9776\u5411\u8abf\u7bc0\u86cb\u767d\u529f\u80fd\u7684\u8b8a\u69cb (allosteric) \u4f4d\u9ede\uff0c\u4e26\u4e14\u901a\u904e\u9776\u5411\u9019\u4e9b\u4f4d\u9ede\u958b\u767c\u51fa\u4e00\u6d41\u7684\u5275\u65b0\u85e5\u7269\u3002HotSpot \u516c\u53f8\u662f\u7b2c\u4e00\u5bb6\u7cfb\u7d71\u5730\u5229\u7528\u81ea\u7136\u8abf\u63a7\u71b1\u9ede(regulatory hotspots)\u9032\u884c\u8b8a\u69cb\u85e5\u7269\u767c\u73fe\u7684\u4f01\u696d\u3002<\/p>\n

HotSpot\u516c\u53f8\u806f\u5408\u5275\u59cb\u4eba\u517c\u9996\u5e2d\u57f7\u884c\u5b98Jonathan Montagu\u5148\u751f\u8aaa\uff1a\u201cHotSpot\u516c\u53f8\u9776\u5411\u7684\u662f\u86cb\u767d\u7d93\u904e\u4e0a\u767e\u842c\u5e74\u7684\u9032\u5316\u904e\u7a0b\u4e26\u5f97\u4ee5\u512a\u5316\u7684\u5929\u7136\u8abf\u63a7\u4f4d\u9ede\u3002\u9019\u4e00\u7b56\u7565\u8b93\u6211\u5011\u80fd\u5920\u958b\u767c\u4f7f\u7528\u540c\u6a23\u8abf\u63a7\u6a5f\u5236\u7684\u5275\u65b0\u85e5\u7269\uff0c\u5b83\u5011\u5177\u5099\u540c\u6a23\u7684\u7cbe\u78ba\u6027\u548c\u6548\u529b\u3002\u8abf\u63a7\u71b1\u9ede\u5728\u85e5\u7269\u7814\u767c\u904e\u7a0b\u4e2d\u9084\u672a\u88ab\u958b\u767c\uff0c\u5b83\u5011\u4ee3\u8868\u8457\u5728\u591a\u7a2e\u75be\u75c5\u9818\u57df\u4e2d\u767c\u73fe\u5168\u65b0\u4e00\u6d41\u85e5\u7269\u7684\u91cd\u5927\u6a5f\u9047\u3002\u201d<\/p>\n

\u82f1\u6587\u4f86\u6e90\uff1aBiospace<\/p>\n","protected":false},"excerpt":{"rendered":"

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