{"id":262359,"date":"2019-04-12T18:23:49","date_gmt":"2019-04-13T01:23:49","guid":{"rendered":"https:\/\/nai500.com\/?p=262359"},"modified":"2019-04-12T18:23:49","modified_gmt":"2019-04-13T01:23:49","slug":"intercept%e7%9a%84nash%e6%96%b0%e8%97%a5%e8%a9%a6%e9%a9%97%e5%8f%96%e5%be%97%e6%88%90%e5%8a%9f%ef%bc%8c%e4%bd%86%e5%8d%b4%e6%9a%97%e8%97%8f%e9%9b%b7%e5%8d%80","status":"publish","type":"post","link":"https:\/\/nai500.com\/zh-hant\/blog\/2019\/04\/intercept%e7%9a%84nash%e6%96%b0%e8%97%a5%e8%a9%a6%e9%a9%97%e5%8f%96%e5%be%97%e6%88%90%e5%8a%9f%ef%bc%8c%e4%bd%86%e5%8d%b4%e6%9a%97%e8%97%8f%e9%9b%b7%e5%8d%80\/","title":{"rendered":"Intercept\u7684NASH\u65b0\u85e5\u8a66\u9a57\u53d6\u5f97\u6210\u529f\uff0c\u4f46\u5374\u6697\u85cf\u96f7\u5340"},"content":{"rendered":"

\u4eca\u5e74\u7684\u570b\u969b\u809d\u81df\u5927\u6703\u7372\u5f97\u4e86\u8f03\u4ee5\u5f80\u66f4\u591a\u7684\u95dc\u6ce8\uff0c\u539f\u56e0\u662f\u751f\u7269\u88fd\u85e5\u516c\u53f8Intercept Pharmaceuticals Inc\uff08NASDAQ: ICPT\uff09\u5728\u6703\u4e0a\u767c\u5e03\u4e86\u809d\u75c5\u65b0\u85e5Ocaliva\uff08\u5967\u8c9d\u81bd\u9178\uff09Regenerate\u8a66\u9a57\u7684\u5b8c\u6574\u7d50\u679c\u3002\u4e0d\u904e\uff0c\u516c\u53f8\u5e77\u672a\u6eff\u8db3\u6295\u8cc7\u8005\u7684\u671f\u5f85\u3002<\/p>\n

\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d\u708e\uff08NASH\uff09\u7684\u60a3\u8005\u7fa4\u9ad4\u6975\u7232\u9f90\u5927\uff0c\u5e77\u4e14\u76ee\u524d\u5c1a\u7121\u7372\u6279\u7684\u6709\u6548\u7642\u6cd5\u3002\u5982\u679c\u67d0\u7a2eNASH\u65b0\u85e5\u7372\u6279\u4e0a\u5e02\uff0c\u5176\u5e74\u5ea6\u92b7\u552e\u984d\u4f30\u8a08\u5728\u6578\u5341\u5104\u898f\u6a21\u3002\u90a3\u9ebd\uff0cIntercept\u6b64\u6b21\u5099\u53d7\u671f\u5f85\u7684\u8a66\u9a57\u7d50\u679c\u767c\u5e03\uff0c\u7232\u4f55\u6c92\u6709\u63d0\u5347\u6295\u8cc7\u8005\u5c0d\u4e8eOcaliva\u5c07\u6210\u7232NASH\u91cd\u78c5\u65b0\u85e5\u7684\u9810\u671f\u5462\uff1f<\/p>\n

\u9f90\u5927\u7684\u5e02\u5834<\/strong><\/p>\n

\u5728\u7f8e\u570b\uff0c\u5927\u7d04\u4e09\u5206\u4e4b\u4e00\u6210\u4eba\u7684\u809d\u81df\u8102\u80aa\u542b\u91cf\u9ad8\u4e8e\u6b63\u5e38\u6c34\u5e73\uff0c\u5176\u4e2d\u7684\u5927\u7d042000\u842c\u4eba\u9084\u60a3\u6709\u6162\u6027\u708e\u75c7\uff0c\u5373\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d\u708e\uff08NASH\uff09\u3002NASH\u60a3\u8005\u9ad4\u5167\u6703\u53cd\u5fa9\u9032\u884c\u514d\u75ab\u7cfb\u7d71\u653b\u64ca\uff0c\u9019\u901a\u5e38\u6703\u5c0e\u81f4\u809d\u81df\u7d44\u7e54\u7684\u640d\u50b7\u548c\u50f5\u786c\uff0c\u4e5f\u5c31\u662f\u6240\u8b02\u7684\u7e96\u7dad\u5316\u3002\u7e96\u7dad\u5316\u60e1\u5316\u53ef\u80fd\u6703\u5c0e\u81f4\u809d\u529f\u80fd\u5fb9\u5e95\u8870\u7aed\uff0c\u9019\u4e5f\u662f\u7232\u4ec0\u9ebdNASH\u6b63\u5728\u6210\u7232\u7f8e\u570b\u809d\u81df\u79fb\u690d\u7684\u9996\u56e0\u3002\u5728\u7f8e\u570b\u548c\u6b50\u6d32\uff0c\u81f3\u5c11\u6709100\u842cNASH\u60a3\u8005\u4f34\u6709\u4e8c\u671f\u6216\u4e09\u671f\u7e96\u7dad\u5316\uff0c\u800cOcaliva\u662f\u9996\u500b\u9032\u5165\u95dc\u9375\u7814\u7a76\uff08\u901a\u5e38\u6307\u7684\u662f\u85e5\u7269\u7684\u4e09\u671f\u81e8\u5e8a\u8a66\u9a57\uff09\u968e\u6bb5\u7684\u6297\u7e96\u7dad\u5316\u85e5\u7269\u3002<\/p>\n

\u6210\u529f\u964d\u4f4e\u7e96\u7dad\u5316\u9032\u7a0b<\/strong><\/p>\n

\u4eca\u5e742\u6708\uff0cIntercept\u767c\u5e03\u7684\u7814\u7a76\u6578\u64da\u986f\u793a\uff0cOcaliva\u5728\u60a3\u8005\u708e\u75c7\u6c92\u6709\u60e1\u5316\u7684\u60c5\u51b5\u4e0b\u986f\u8457\u964d\u4f4e\u4e86\u7e96\u7dad\u5316\u7a0b\u5ea6\u3002\u4e0d\u904e\u53ef\u60dc\u7684\u662f\uff0c\u4e8c\u671f\u6216\u4e09\u671f\u7e96\u7dad\u5316\u60a3\u8005\u7684NASH\u75c7\u72c0\u5e77\u672a\u51fa\u73fe\u986f\u8457\u6539\u5584\u3002\u6b64\u5916\uff0cOcaliva\u5c0d\u4e8e\u4e00\u671f\u809d\u7e96\u7dad\u5316\u60a3\u8005\u7684\u6cbb\u7642\u6548\u679c\u66f4\u7232\u660e\u986f\u3002\u7d93\u904e18\u500b\u6708\u7684\u9ad8\u5291\u91cf\u6cbb\u7642\u5f8c\uff0c14.9%\u7684NASH\u60a3\u8005\uff08\u5305\u62ec\u4e00\u671f\u3001\u4e8c\u671f\u548c\u4e09\u671f\u7e96\u7dad\u5316\uff09\u6c92\u6709\u51fa\u73fe\u708e\u75c7\uff0c\u9060\u9ad8\u4e8e\u5b89\u6170\u5291\u5c0d\u7167\u7d44\u76847.9%\u3002<\/p>\n

\u9452\u4e8e\u7e96\u7dad\u5316\u6975\u9ad8\u7684\u5371\u96aa\u6027\uff0c\u5982\u679c\u4e00\u7a2e\u5019\u9078\u85e5\u54ea\u6015\u4e0d\u80fd\u986f\u8457\u964d\u4f4eNASH\u75c7\u72c0\uff0c\u4f46\u53ea\u8981\u80fd\u591f\u9006\u8f49\u7e96\u7dad\u5316\uff0c\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7ba1\u5c40\uff08FDA\uff09\u90fd\u9858\u610f\u63a5\u53d7\u9019\u6a23\u7684\u65b0\u85e5\u7533\u8acb\u3002\u5f9e\u6709\u6548\u6027\u7684\u89d2\u5ea6\u4f86\u770b\uff0cOcaliva\u6709\u7406\u7531\u7372\u5f97FDA\u7684\u6279\u51c6\u3002<\/p>\n

\u6210\u529f\u80cc\u5f8c\u7684\u6697\u7901<\/strong><\/p>\n

Regenerate\u7814\u7a76\u8a55\u4f30\u4e86\u5169\u7a2e\u5291\u91cf\uff0810mg\u548c25mg\uff0c\u6bcf\u65e5\u4e00\u6b21\uff09\u7684Ocaliva\u76f8\u8f03\u5b89\u6170\u5291\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\uff0c\u5176\u4e2d\u4f4e\u5291\u91cf\u7d44\u7684\u7d50\u679c\u4e0d\u591f\u7406\u60f3\u30022\u6708\u8a66\u9a57\u7d50\u679c\u767c\u5e03\u5f8c\uff0cIntercept\u7684\u80a1\u50f9\u61c9\u8072\u4e0b\u632b\uff0c\u539f\u56e0\u662f\u5e02\u5834\u8a8d\u7232\u6709\u6548\u5291\u91cf\u53ef\u80fd\u904e\u9ad8\u3002<\/p>\n

\u96d6\u7136\u9ad8\u5291\u91cfOcaliva\u7684\u6709\u6548\u6027\u7372\u5f97\u8a8d\u53ef\uff0c\u4f46\u5374\u6697\u85cf\u8457\u5de8\u5927\u7684\u96b1\u6182\uff1a51%\u63a5\u53d7\u6709\u6548\u5291\u91cf\u6cbb\u7642\u7684\u60a3\u8005\u51fa\u73fe\u6162\u6027\u7619\u7662\uff0c\u5e77\u4e14\u5176\u4e2d\u9084\u67099%\u7684\u60a3\u8005\u56e0\u7232\u7619\u7662\u75c7\u800c\u7d42\u6b62\u6cbb\u7642\u3002\u7619\u7662\u53ef\u80fd\u662f\u7531\u53d7\u640d\u809d\u81df\u6ef2\u6f0f\u81bd\u6c41\u9178\u6240\u5f15\u8d77\uff0c\u56e0\u6b64\u503c\u5f97\u56b4\u8085\u5c0d\u5f85\u3002\u6b64\u5916\uff0c\u7814\u7a76\u4e2d\u4e0d\u52301%\u7684\u60a3\u8005\u7684\u809d\u9176\u6c34\u5e73\u904e\u9ad8\u3002Intercept\u57282\u6708\u6307\u51fa\uff0c\u6240\u67093\u500b\u5206\u7d44\u5747\u51fa\u73fe\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff0c\u5176\u4e2d\u6709\u6548\u5291\u91cf\u6cbb\u7642\u7d44\u7684\u9019\u4e00\u6578\u503c\u66f4\u9ad8\u3002<\/p>\n

\u6c92\u6709\u65b0\u7684\u4fe1\u606f\u62ab\u9732<\/strong><\/p>\n

\u6295\u8cc7\u8005\u6b64\u6b21\u53c3\u8207\u570b\u5bb6\u809d\u81df\u5927\u6703\uff0c\u662f\u5e0c\u671b\u7372\u5f97\u6709\u95dcOcaliva\u5b89\u5168\u6027\u4ee5\u53ca\u6709\u6548\u6027\u7684\u66f4\u591a\u4fe1\u606f\u3002\u4e0d\u904e\u4ee4\u4eba\u5931\u671b\u7684\u662f\uff0c\u9664\u4e86Regenerate\u7814\u7a76\u7d50\u679c\u7684\u9075\u65b9\u6848\u5206\u6790\uff0cIntercept\u5e77\u672a\u63d0\u4f9b\u4efb\u4f55\u65b0\u7684\u4fe1\u606f\u3002<\/p>\n

Regenerate\u8a66\u9a57\u5c1a\u672a\u5b8c\u6210\u60a3\u8005\u62db\u52df\u5de5\u4f5c\uff0c\u540c\u6642Intercept\u64c1\u67091,968\u540d\u53d7\u8a66\u8005\u7684\u90e8\u5206\u5b89\u5168\u6027\u6578\u64da\u3002\u907a\u61be\u7684\u662f\uff0c\u53c3\u8207Regenerate\u7814\u7a763\u671f\u8a66\u9a57\u7684931\u540d\u60a3\u8005\u7576\u4e2d\uff0cIntercept\u50c5\u7372\u5f97668\u540d\u60a3\u8005\u768418\u500b\u6708\u6d3b\u7d44\u7e54\u6aa2\u67e5\u7d50\u679c\u3002\u7d50\u679c\u986f\u793a\uff0c13.3%\u7684\u60a3\u8005\u7684\u7e96\u7dad\u5316\u51fa\u73fe\u5169\u500b\u9ede\u53ca\u4ee5\u4e0a\u7684\u6539\u5584\uff0c\u800c\u5b89\u6170\u5291\u5c0d\u7167\u7d44\u7684\u9019\u4e00\u6bd4\u4f8b\u50c5\u72324.5%\u3002<\/p>\n

\u4e0d\u904e\uff0c\u76e3\u7ba1\u6a5f\u69cb\u4e00\u822c\u90fd\u5ffd\u7565\u5b50\u7d44\u6578\u64da\uff0c\u5c24\u5176\u662f\u4e0a\u8ff0\u6578\u64da\u9084\u5254\u9664\u4e86\u63d0\u524d\u9000\u51fa\u7684\u60a3\u8005\u3002\u6211\u5011\u5f9eIntercept\u7684\u9075\u65b9\u6848\u5206\u6790\u5f97\u51fa\u7684\u552f\u4e00\u7d50\u8ad6\u662f\uff0c\u8a72\u516c\u53f8\u61c9\u7576\u958b\u5c55\u65b0\u7684\u95dc\u9375\u6027\u8a66\u9a57\uff0c\u5e77\u4e14\u62db\u52df\u9000\u51fa\u53ef\u80fd\u6027\u66f4\u4f4e\u7684NASH\u60a3\u8005\u3002<\/p>\n

\u6700\u58de\u7684\u5047\u8a2d<\/strong><\/p>\n

\u5728\u6b64\u6b21\u570b\u969b\u809d\u81df\u5927\u6703\u4e0a\uff0cIntercept\u5c0d\u6240\u67091,968\u540d\u4f34\u6709\u7e96\u7dad\u5316\u7684NASH\u60a3\u8005\u7684\u540c\u6a23\u7684\u5b89\u5168\u6027\u6578\u64da\u9032\u884c\u4e86\u91cd\u65b0\u8868\u8ff0\u3002\u7559\u5fc3\u7684\u6295\u8cc7\u8005\u61c9\u8a72\u5df2\u7d93\u6ce8\u610f\u5230\uff0c\u8a72\u516c\u53f8\u5e77\u672a\u62ab\u9732\u4efb\u4f55\u6709\u95dc\u53c3\u8207\u95dc\u9375\u8a66\u9a57\u7684931\u540d\u60a3\u8005\u6216\u5b8c\u621018\u500b\u6708\u6d3b\u7d44\u7e54\u6aa2\u67e5\u7684668\u540d\u60a3\u8005\u7684\u5b89\u5168\u6027\u6578\u64da\u3002<\/p>\n

Intercept\u8a08\u5283\u4eca\u5e74\u4e0b\u534a\u5e74\u5411FDA\u63d0\u4ea4Ocaliva\u7684\u65b0\u85e5\u7533\u8acb\uff0c\u5c07\u8a72\u85e5\u7684\u9069\u61c9\u75c7\u7bc4\u570d\u64f4\u5927\u81f3\u4f34\u6709\u7e96\u7dad\u5316\u7684NASH\u60a3\u8005\u3002\u5c4a\u6642\uff0c\u76e3\u7ba1\u6a5f\u69cb\u61c9\u8a72\u4e0d\u6703\u653e\u904e\u6cbb\u7642\u7d44\u7684\u5b89\u5168\u6027\u6578\u64da\u3002\u7531\u4e8e\u67d0\u7a2e\u539f\u56e0\uff0cIntercept\u5e77\u4e0d\u60f3\u62ab\u9732\u9019\u4e9b\u60a3\u8005\u7684\u5b89\u5168\u6027\u6578\u64da\u3002\u53ef\u4ee5\u60f3\u898b\uff0c\u5982\u679c\u9019\u4e00\u6578\u64da\u6b63\u9762\uff0cIntercept\u5c31\u4e0d\u6703\u523b\u610f\u96b1\u779e\u3002<\/p>\n

\u5728FDA\u7684\u8a55\u4f30\u610f\u898b\u51fa\u7210\u524d\uff0cOcaliva\u4f5c\u7232\u6f5c\u5728\u7684NASH\u91cd\u78c5\u85e5\u7684\u524d\u666f\u9084\u5f88\u4e0d\u660e\u6717\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

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