{"id":270181,"date":"2019-06-24T22:57:01","date_gmt":"2019-06-25T05:57:01","guid":{"rendered":"https:\/\/nai500.com\/?p=270181"},"modified":"2019-06-24T22:57:01","modified_gmt":"2019-06-25T05:57:01","slug":"%e6%8b%93%e8%87%bb%e7%94%9f%e7%89%a9%e8%88%87genfit%e7%b0%bd%e7%bd%b2elafibranor%e5%a4%a7%e4%b8%ad%e8%8f%af%e5%8d%80%e7%8d%a8%e5%ae%b6%e7%94%a2%e5%93%81%e6%8e%88%e6%ac%8a%e5%8f%8a%e6%88%b0%e7%95%a5","status":"publish","type":"post","link":"https:\/\/nai500.com\/zh-hant\/blog\/2019\/06\/%e6%8b%93%e8%87%bb%e7%94%9f%e7%89%a9%e8%88%87genfit%e7%b0%bd%e7%bd%b2elafibranor%e5%a4%a7%e4%b8%ad%e8%8f%af%e5%8d%80%e7%8d%a8%e5%ae%b6%e7%94%a2%e5%93%81%e6%8e%88%e6%ac%8a%e5%8f%8a%e6%88%b0%e7%95%a5\/","title":{"rendered":"\u62d3\u81fb\u751f\u7269\u8207Genfit\u7c3d\u7f72Elafibranor\u5927\u4e2d\u83ef\u5340\u7368\u5bb6\u7522\u54c1\u6388\u6b0a\u53ca\u6230\u7565\u5408\u4f5c\u5354\u8b70"},"content":{"rendered":"<p>\u62d3\u81fb\u751f\u7269\u4eca\u5929\u5ba3\u4f48\u8207\u6cd5\u570bGenfit\u7c3d\u7f72\u4e86\u7368\u5bb6\u7522\u54c1\u6388\u6b0a\u548c\u6230\u7565\u5408\u4f5c\u5354\u8b70\uff0c\u5f8c\u8005\u662f\u4e00\u5bb6\u5c08\u6ce8\u65bc\u7814\u767c\u4ee3\u8b1d\u75be\u75c5\u548c\u809d\u81df\u75be\u75c5\u6cbb\u7642\u53ca\u8a3a\u65b7\u7684\u6210\u719f\u5275\u65b0\u751f\u7269\u91ab\u85e5\u4f01\u696d\u3002<\/p>\n<p>\u62d3\u81fb\u5c07\u7372\u5f97elafibranor\u5728\u5927\u4e2d\u83ef\u5340\uff08\u4e2d\u570b\u5927\u9678\u3001\u9999\u6e2f\u3001\u6fb3\u9580\u3001\u81fa\u7063\uff09\u7684\u7368\u5bb6\u958b\u767c\u3001\u8a3b\u518a\u3001\u548c\u5546\u696d\u5316\u6b0a\u76ca\uff1b\u6388\u6b0a\u7684\u9069\u61c9\u75c7\u5305\u62ec\u975e\u9152\u7cbe\u6027\u809d\u708e\uff08NASH\uff09\u548c\u539f\u767c\u6027\u81bd\u6c41\u6027\u81bd\u7ba1\u708e\uff08PBC\uff09\u3002<\/p>\n<p>GENFIT\u5c07\u7372\u5f973500\u842c\u7f8e\u5143\u7684\u9996\u4ed8\u6b3e\uff0c\u4e26\u4e14\u6709\u6b0a\u5229\u7372\u5f97\u4e0d\u9ad8\u65bc1.93\u5104\u7f8e\u5143\u7684\u81e8\u5e8a\u3001\u8a3b\u518a\u3001\u548c\u5546\u696d\u5316\u91cc\u7a0b\u7891\u4ed8\u6b3e\u3002\u96d9\u65b9\u9084\u5c07\u5171\u540c\u958b\u767c\u5176\u4ed6\u975e\u9152\u7cbe\u6027\u809d\u708e\uff08NASH\uff09\u548c\u539f\u767c\u6027\u81bd\u6c41\u6027\u81bd\u7ba1\u708e\uff08PBC\uff09\u9818\u57df\u7684\u7814\u767c\u9805\u76ee\uff0c\u5305\u62ecelafibranor\uff08PPAR \u03b1\/\u03b4\u96d9\u91cd\u6fc0\u52d5\u5291\uff09\u548c\u62d3\u81fb\u81ea\u8eab\u7ba1\u7dda\u88e1\u7684TERN-101(FXR\u53d7\u9ad4\u6fc0\u52d5\u5291)\u3001TERN-201\uff08SSAO\u6291\u5236\u5291\uff09\uff0c\u4ee5\u53ca\u76ee\u524d\u8655\u65bc\u81e8\u5e8a\u524d\u968e\u6bb5\u7684(THR) \u03b2\u7279\u7570\u6027\u6fc0\u52d5\u5291\u548cASK-1\u6291\u5236\u5291\u7684\u806f\u5408\u7528\u85e5\u7814\u7a76\u3002<\/p>\n<p>\u62d3\u81fb\u751f\u7269\u7684\u9996\u5e2d\u57f7\u884c\u5b98\u9418\u5049\u6771\u535a\u58eb\u8868\u793a\uff1a\u201c\u62d3\u81fb\u81f4\u529b\u65bc\u7d66\u4e2d\u570b\u548c\u5168\u7403\u5e02\u5834\u5e36\u4f86\u809d\u75c5\u9818\u57df\u7684\u5275\u65b0\u7642\u6cd5\u3002\u6211\u5011\u548cGenfit\u7684\u6230\u7565\u5408\u4f5c\u662f\u6211\u5011\u516c\u53f8\u767c\u5c55\u7684\u91cd\u8981\u4e00\u6b65\u3002\u6211\u5011\u76f8\u4fe1\u806f\u5408\u7528\u85e5\u5c07\u6703\u5f88\u5feb\u7684\u6210\u70ba\u975e\u9152\u7cbe\u6027\u809d\u708e\uff08NASH\uff09\u7684\u6a19\u6e96\u7642\u6cd5\u3002Elafibrnor\u662f\u4e00\u500b\u6709\u8457\u8207\u6211\u5011\u76ee\u524d\u7522\u54c1\u7dda\u4f5c\u7528\u6a5f\u5236\u4e92\u88dc\u7684\u665a\u671f\u7522\u54c1\uff0c\u5b83\u7684\u5f15\u5165\u5c07\u4f7f\u5f97\u6211\u5011\u53ef\u4ee5\u66f4\u597d\u7684\u57f7\u884c\u9019\u4e00\u6230\u7565\u3002\u201d<\/p>\n<p>Elafibranor\u662fGenfit\u7522\u54c1\u7ba1\u7dda\u4e2d\u7684\u6838\u5fc3\u7522\u54c1\uff0c\u5176\u4f5c\u7528\u65bcPPAR alpha\/delta\u901a\u8def\u4f86\u6cbb\u7642\u975e\u9152\u7cbe\u6027\u809d\u708e\uff0c\u9700\u8981\u6bcf\u5929\u53e3\u670d\u4e00\u6b21\u3002\u6839\u64da\u81e8\u5e8a\u6578\u64da\uff0cGenfit\u76f8\u4fe1Elafibranor\u6709\u6f5b\u529b\u5f9e\u5305\u62ec\u708e\u75c7\u3001\u80f0\u5cf6\u7d20\u654f\u611f\u5ea6\u3001\u8102\u80aa\u4ee3\u8b1d\u3001\u4ee5\u53ca\u809d\u529f\u80fd\u6307\u6a19\u7b49\u4e0d\u540c\u7dad\u5ea6\u63a7\u5236\u975e\u9152\u7cbe\u6027\u809d\u708e\u3002<\/p>\n<p>\u82f1\u6587\u4f86\u6e90\uff1aBiospace<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u62d3\u81fb\u751f\u7269\u4eca\u5929\u5ba3\u4f48\u8207\u6cd5\u570bGenfit\u7c3d\u7f72\u4e86\u7368\u5bb6\u7522\u54c1\u6388\u6b0a\u548c\u6230\u7565\u5408\u4f5c\u5354\u8b70\uff0c\u5f8c\u8005\u662f\u4e00\u5bb6\u5c08\u6ce8\u65bc\u7814\u767c\u4ee3\u8b1d\u75be\u75c5\u548c\u809d\u81df\u75be\u75c5\u6cbb\u7642 [&hellip;]<\/p>\n","protected":false},"author":9,"featured_media":270179,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[426],"tags":[809,927,563,570,564],"class_list":["post-270181","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-market-news-zh-hant","tag-809","tag-927","tag--zh-hant","tag-570","tag-564","sectors-life-science-zh-hant","locations-china-zh-hant","locations-europe-zh-hant","locations-us-zh-hant"],"acf":[],"_links":{"self":[{"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/posts\/270181","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/comments?post=270181"}],"version-history":[{"count":0,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/posts\/270181\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/media\/270179"}],"wp:attachment":[{"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/media?parent=270181"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/categories?post=270181"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/tags?post=270181"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}