{"id":286811,"date":"2019-08-14T00:00:00","date_gmt":"2019-08-14T07:00:00","guid":{"rendered":"http:\/\/62.151.178.150\/blog\/2019\/08\/deciphera%e6%99%9a%e6%9c%9fgist%e7%9a%84%e9%97%9c%e9%8d%b5%e4%b8%89%e6%9c%9f%e8%87%a8%e5%ba%8a%e7%a0%94%e7%a9%b6invictus%e7%8d%b2%e5%be%97%e7%a9%8d%e6%a5%b5%e7%b5%90%e6%9e%9c\/"},"modified":"2019-09-23T07:38:08","modified_gmt":"2019-09-23T14:38:08","slug":"deciphera%e6%99%9a%e6%9c%9fgist%e7%9a%84%e9%97%9c%e9%8d%b5%e4%b8%89%e6%9c%9f%e8%87%a8%e5%ba%8a%e7%a0%94%e7%a9%b6invictus%e7%8d%b2%e5%be%97%e7%a9%8d%e6%a5%b5%e7%b5%90%e6%9e%9c","status":"publish","type":"post","link":"https:\/\/nai500.com\/zh-hant\/blog\/2019\/08\/deciphera%e6%99%9a%e6%9c%9fgist%e7%9a%84%e9%97%9c%e9%8d%b5%e4%b8%89%e6%9c%9f%e8%87%a8%e5%ba%8a%e7%a0%94%e7%a9%b6invictus%e7%8d%b2%e5%be%97%e7%a9%8d%e6%a5%b5%e7%b5%90%e6%9e%9c\/","title":{"rendered":"Deciphera\u665a\u671fGIST\u7684\u95dc\u9375\u4e09\u671f\u81e8\u5e8a\u7814\u7a76INVICTUS\u7372\u5f97\u7a4d\u6975\u7d50\u679c"},"content":{"rendered":"

Deciphera Pharmaceuticals, Inc.\uff08\u7d0d\u65af\u9054\u514b\u80a1\u7968\u4ee3\u78bc\uff1aDCPH\uff09\u662f\u4e00\u5bb6\u5c08\u6ce8\u65bc\u89e3\u6c7a\u816b\u7624\u8010\u85e5\u6027\u95dc\u9375\u6a5f\u5236\u7684\u81e8\u5e8a\u968e\u6bb5\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u4eca\u5929\u516c\u4f48\u4e86Ripretinib\u4f5c\u70ba\u4e00\u7a2e\u5ee3\u8b5cKIT\u53caPDGFR\u03b1\u6291\u5236\u5291\u7528\u65bc\u6cbb\u7642\u56db\u7dda\u53ca\u56db\u7dda\u4ee5\u4e0a\u80c3\u8178\u9053\u9593\u8cea\u7624(GIST)\u60a3\u8005\u7684\u95dc\u9375\u4e09\u671f\u81e8\u5e8a\u7814\u7a76INVICTUS\u7372\u5f97\u7a4d\u6975\u7d50\u679c\u3002 Fox Chase\u764c\u75c7\u4e2d\u5fc3Margaret von Mehren\u535a\u58eb\u8868\u793a\uff1a\u201c\u5c0d\u65bc\u90a3\u4e9b\u5df2\u7d93\u63a5\u53d7\u904e\u6a19\u6e96\u6cbb\u7642\u5931\u6557\u7684\u665a\u671fGIST\u60a3\u8005\u4f86\u8aaa\uff0c\u4ed6\u5011\u6025\u9700\u65b0\u7684\u6cbb\u7642\u624b\u6bb5\u4f86\u63a7\u5236\u75be\u75c5\u7684\u9032\u5c55\u3002\u6b64\u9805\u96a8\u6a5f\u3001\u5b89\u6170\u5291\u5c0d\u7167\u7684\u4e09\u671f\u81e8\u5e8a\u7814\u7a76\u7684\u7d50\u679c\u975e\u5e38\u4ee4\u4eba\u8b9a\u6b4e\uff0c\u986f\u793a\u4e86Ripretinib\u53ef\u4ee5\u986f\u8457\u6539\u5584\u65e2\u5f80\u7d93\u904e\u591a\u7dda\u6cbb\u7642\u7684GIST\u60a3\u8005\u7684PFS\uff0c\u7279\u5225\u503c\u5f97\u6ce8\u610f\u7684\u9084\u6709\u8a72\u9805\u7814\u7a76\u4e2d\u89c0\u5bdf\u5230\u7684\u986f\u8457\u7684\u7e3d\u751f\u5b58\u7372\u76ca\u3002\u201d INVICTUS\u4e09\u671f\u81e8\u5e8a\u7814\u7a76\u662f\u4e00\u9805\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u7684\u570b\u969b\u591a\u4e2d\u5fc3\u7814\u7a76\uff0c\u5171\u5165\u7d44129\u4f8b\u60a3\u8005\uff0c\u65e8\u5728\u8a55\u4f30Ripretinib\u5728\u665a\u671fGIST\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\uff0c\u8010\u53d7\u6027\u548c\u7642\u6548\uff0c\u9019\u4e9b\u60a3\u8005\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u904e\u5305\u62ec\u4f0a\u99ac\u66ff\u5c3c\u3001\u8212\u5c3c\u66ff\u5c3c\u548c\u745e\u6208\u975e\u5c3c\u5728\u5167\u7684\u6cbb\u7642\u65b9\u6848\u3002\u8a72\u7814\u7a76\u4e2d\uff0c\u76f8\u6bd4\u5b89\u6170\u5291\uff0cRipretinib\u5728\u7e3d\u751f\u5b58\u671f\uff08OS\uff09\u9019\u4e00\u6b21\u8981\u7814\u7a76\u7d42\u9ede\u4e5f\u986f\u793a\u51fa\u6709\u81e8\u5e8a\u610f\u7fa9\u7684\u6539\u5584\u3002 Deciphera\u7e3d\u88c1\u517c\u9996\u5e2d\u57f7\u884c\u5b98Hoerter\u8868\u793a\uff1a\u201c\u4eca\u5929\u662f\u6211\u5011\u8e10\u884c\u63d0\u4f9b\u5275\u65b0\u764c\u75c7\u6cbb\u7642\u85e5\u7269\u9019\u4e00\u4f7f\u547d\u7684\u91cd\u8981\u91cc\u7a0b\u7891\u3002\u5728\u6b64\uff0c\u6211\u4ee3\u8868Deciphera\u5168\u9ad4\u6210\u54e1\uff0c\u611f\u8b1d\u53c3\u8207INVICTUS\u7814\u7a76\u7684\u60a3\u8005\u548c\u91ab\u8b77\u4eba\u54e1\u3002INVICTUS\u7814\u7a76\u7684\u6578\u64da\u4f7f\u6211\u5011\u66f4\u52a0\u5805\u4fe1\uff0cRipretinib\u6709\u53ef\u80fd\u6539\u8b8aGIST\u7684\u6cbb\u7642\u73fe\u72c0\u3002\u201d \u6839\u64daINVICTUS\u7814\u7a76\u7684\u967d\u6027\u6578\u64da\uff0cDeciphera\u516c\u53f8\u9810\u8a08\u5c07\u57282020\u5e74\u7b2c\u4e00\u5b63\u5ea6\u5411\u7f8e\u570bFDA\u63d0\u4ea4Ripretinib\u7684\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\uff08NDA\uff09\uff0c\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u5df2\u63a5\u53d7\u4f0a\u99ac\u66ff\u5c3c\u3001\u8212\u5c3c\u66ff\u5c3c\u548c\u745e\u6208\u975e\u5c3c\u6cbb\u7642\u7684\u665a\u671fGIST\u60a3\u8005\u3002 \u82f1\u6587\u4f86\u6e90\uff1aBiospace<\/p>\n","protected":false},"excerpt":{"rendered":"

Deciphera Pharmaceuticals, Inc.\uff08\u7d0d\u65af\u9054\u514b\u80a1\u7968\u4ee3\u78bc\uff1aDCPH\uff09\u662f\u4e00\u5bb6\u5c08\u6ce8\u65bc\u89e3\u6c7a\u816b […]<\/p>\n","protected":false},"author":9,"featured_media":289460,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[1522,194],"tags":[809,927,563,459,570],"class_list":["post-286811","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-1522","category-uncategorized_zh-hant","tag-809","tag-927","tag--zh-hant","tag-459","tag-570","sectors-life-science-zh-hant","locations-us-zh-hant"],"acf":[],"_links":{"self":[{"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/posts\/286811","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/comments?post=286811"}],"version-history":[{"count":0,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/posts\/286811\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/media\/289460"}],"wp:attachment":[{"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/media?parent=286811"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/categories?post=286811"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/tags?post=286811"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}