{"id":287891,"date":"2019-09-07T00:00:00","date_gmt":"2019-09-07T07:00:00","guid":{"rendered":"http:\/\/62.151.178.150\/blog\/2019\/09\/%e5%be%b7%e5%9c%8b%e5%8b%83%e6%9e%97%e6%a0%bc%e6%ae%b7%e6%a0%bc%e7%bf%b0%e6%94%9c%e6%89%8b%e5%8d%b0%e5%ba%a6%e9%ad%af%e8%b3%93%e8%a3%bd%e8%97%a5\/"},"modified":"2019-09-23T22:25:34","modified_gmt":"2019-09-24T05:25:34","slug":"%e5%be%b7%e5%9c%8b%e5%8b%83%e6%9e%97%e6%a0%bc%e6%ae%b7%e6%a0%bc%e7%bf%b0%e6%94%9c%e6%89%8b%e5%8d%b0%e5%ba%a6%e9%ad%af%e8%b3%93%e8%a3%bd%e8%97%a5","status":"publish","type":"post","link":"https:\/\/nai500.com\/zh-hant\/blog\/2019\/09\/%e5%be%b7%e5%9c%8b%e5%8b%83%e6%9e%97%e6%a0%bc%e6%ae%b7%e6%a0%bc%e7%bf%b0%e6%94%9c%e6%89%8b%e5%8d%b0%e5%ba%a6%e9%ad%af%e8%b3%93%e8%a3%bd%e8%97%a5\/","title":{"rendered":"\u5fb7\u570b\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u651c\u624b\u5370\u5ea6\u9b6f\u8cd3\u88fd\u85e5"},"content":{"rendered":"<p>\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u8207\u9b6f\u8cd3\u6709\u9650\u516c\u53f8\uff08\u9b6f\u8cd3\uff09\u4eca\u65e5\u5ba3\u4f48\u96d9\u65b9\u5c31\u9b6f\u8cd3\u516c\u53f8\u7684MEK\u6291\u5236\u5291\u5316\u5408\u7269\uff08LNP3794\uff09\u9054\u6210\u6388\u6b0a\u3001\u7814\u767c\u8207\u5546\u696d\u5316\u5354\u8b70\u3002LNP3794\u662f\u4e00\u7a2e\u91dd\u5c0d\u96e3\u4ee5\u6cbb\u7652\u7684\u764c\u75c7\u60a3\u8005\u7684\u6f5b\u5728\u9776\u5411\u6cbb\u7642\u3002\u6b64\u6b21\u5408\u4f5c\u65e8\u5728\u958b\u767c\u9b6f\u8cd3\u7684\u5148\u5c0eMEK\u6291\u5236\u5291\u5316\u5408\u7269\uff0c\u4e26\u8207\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u7684\u5275\u65b0KRAS\u6291\u5236\u5291\u76f8\u7d50\u5408\uff0c\u7528\u65bc\u651c\u5e36\u5ee3\u6cdb\u7684\u81f4\u764c\u57fa\u56e0KRAS\u7a81\u8b8a\u7684\u80c3\u8178\u9053\u548c\u80ba\u764c\u60a3\u8005\u3002  \u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u5168\u7403\u764c\u75c7\u7814\u7a76\u8ca0\u8cac\u4ebaNorbert Kraut\u535a\u58eb\u8aaa\u9053\u3002\u201c\u6211\u5011\u76f8\u4fe1\u9019\u6b21\u5408\u4f5c\u5b9a\u80fd\u52a9KRAS\u9805\u76ee\u4e00\u81c2\u4e4b\u529b\u3002\u6211\u5011\u5df2\u7d93\u958b\u767c\u51fa\u4e86\u5168\u9762\u7684\u65b9\u6cd5\u4f86\u5f9e\u6839\u672c\u4e0a\u6210\u529f\u89e3\u6c7a\u81f4\u764c\u7684KRAS\u2013RAF\u2013MEK\u2013ERK\u8def\u5f91\u3002\u800c\u9019\u4e00\u5408\u4f5c\u662f\u6211\u5011\u9577\u671f\u6230\u7565\u7684\u53e6\u4e00\u500b\u81f3\u95dc\u91cd\u8981\u7684\u7d44\u6210\u90e8\u5206\uff0c\u4ee5\u9054\u6210\u70ba\u60a3\u8005\u63d0\u4f9b\u65b0\u7684\u6cbb\u7642\u65b9\u6cd5\u3001\u6230\u52dd\u96e3\u6cbb\u7652\u764c\u75c7\u7684\u76ee\u6a19\u3002\u201d  \u6b64\u6b21\u5408\u4f5c\u7684\u6230\u7565\u76ee\u6a19\u662f\u5c07\u91cd\u9ede\u653e\u5728\u5177\u6709KRAS\u7a81\u8b8a\u7684\u80c3\u8178\u9053\u6216\u80ba\u764c\u60a3\u8005\u8eab\u4e0a\uff0c\u9019\u985e\u4e9e\u7d44\u4eba\u7fa4\u76ee\u524d\u6025\u9700\u66f4\u6709\u6548\u7684\u6cbb\u7642\u65b9\u6848\u3002KRAS\u7a81\u8b8a\u5360\u6240\u6709\u4eba\u985e\u8f49\u79fb\u764c\u7684\u4e03\u5206\u4e4b\u4e00\uff0c\u9019\u4e5f\u4f7f\u5176\u6210\u70ba\u6700\u983b\u7e41\u7a81\u8b8a\u7684\u81f4\u764c\u57fa\u56e0\u3002\u80f0\u817a\u764c\u3001\u7d50\u76f4\u8178\u764c\u548c\u80ba\u817a\u764c\u7684\u7a81\u8b8a\u7387\u5206\u5225\u8d85\u904e90%\u300140%\u548c30%\u3002\u81e8\u5e8a\u524d\u6578\u64da\u986f\u793a\uff0c\u5c07\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u7684\u65b0\u578bKRAS\u6291\u5236\u5291\u548cMEK\u6291\u5236\u5291\u76f8\u7d50\u5408\u53ef\u63d0\u9ad8\u6297\u816b\u7624\u6d3b\u6027\u3002  \u9b6f\u8cd3\u5c07\u6536\u52302000\u842c\u7f8e\u5143\u7684\u9810\u4ed8\u6b3e\uff0c\u4e4b\u5f8c\u9084\u5c07\u6709\u6b0a\u7372\u5f97\u5305\u62ec\u6210\u529f\u5b8c\u6210\u8a2d\u5b9a\u7684\u81e8\u5e8a\u3001\u6cd5\u52d9\u548c\u5546\u696d\u5316\u91cc\u7a0b\u7891\u5728\u5167\u7684\u6f5b\u5728\u968e\u6bb5\u6027\u4ed8\u6b3e\u7e3d\u984d\u9ad8\u90547\u5104\u7f8e\u5143\u3002\u6b64\u5916\uff0c\u9b6f\u8cd3\u9084\u6709\u6b0a\u7372\u5f97\u5169\u4f4d\u6578\u7684\u7522\u54c1\u92b7\u552e\u6b0a\u5229\u91d1\u3002  \u82f1\u6587\u4f86\u6e90\uff1aBiospace<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u8207\u9b6f\u8cd3\u6709\u9650\u516c\u53f8\uff08\u9b6f\u8cd3\uff09\u4eca\u65e5\u5ba3\u4f48\u96d9\u65b9\u5c31\u9b6f\u8cd3\u516c\u53f8\u7684MEK\u6291\u5236\u5291\u5316\u5408\u7269\uff08LNP3794\uff09\u9054\u6210\u6388\u6b0a\u3001\u7814\u767c\u8207 [&hellip;]<\/p>\n","protected":false},"author":9,"featured_media":291005,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[1522,194],"tags":[809,927,459,563,644,564],"class_list":["post-287891","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-1522","category-uncategorized_zh-hant","tag-809","tag-927","tag-459","tag--zh-hant","tag-644","tag-564","sectors-life-science-zh-hant","locations-europe-zh-hant","locations-us-zh-hant"],"acf":[],"_links":{"self":[{"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/posts\/287891","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/comments?post=287891"}],"version-history":[{"count":0,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/posts\/287891\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/media\/291005"}],"wp:attachment":[{"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/media?parent=287891"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/categories?post=287891"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/tags?post=287891"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}