{"id":300407,"date":"2019-10-30T17:57:29","date_gmt":"2019-10-31T00:57:29","guid":{"rendered":"https:\/\/nai500.com\/blog\/2019\/10\/%e5%9f%ba%e5%9b%a0%e7%bc%96%e8%be%91%e5%85%ac%e5%8f%b8crispr-therapeutics%e8%82%a1%e4%bb%b7%e6%9c%89%e6%9c%9b%e5%86%8d%e6%ac%a1%e5%88%9b%e5%87%ba%e6%96%b0%e9%ab%98%e7%9a%843%e4%b8%aa%e7%90%86%e7%94%b1\/"},"modified":"2019-10-30T17:57:46","modified_gmt":"2019-10-31T00:57:46","slug":"%e5%9f%ba%e5%9b%a0%e7%b7%a8%e8%bc%af%e5%85%ac%e5%8f%b8crispr-therapeutics%e8%82%a1%e5%83%b9%e6%9c%89%e6%9c%9b%e5%86%8d%e6%ac%a1%e5%89%b5%e5%87%ba%e6%96%b0%e9%ab%98%e7%9a%843%e5%80%8b%e7%90%86%e7%94%b1","status":"publish","type":"post","link":"https:\/\/nai500.com\/zh-hant\/blog\/2019\/10\/%e5%9f%ba%e5%9b%a0%e7%b7%a8%e8%bc%af%e5%85%ac%e5%8f%b8crispr-therapeutics%e8%82%a1%e5%83%b9%e6%9c%89%e6%9c%9b%e5%86%8d%e6%ac%a1%e5%89%b5%e5%87%ba%e6%96%b0%e9%ab%98%e7%9a%843%e5%80%8b%e7%90%86%e7%94%b1\/","title":{"rendered":"\u57fa\u56e0\u7de8\u8f2f\u516c\u53f8CRISPR Therapeutics\u80a1\u50f9\u6709\u671b\u518d\u6b21\u5275\u51fa\u65b0\u9ad8\u76843\u500b\u7406\u7531"},"content":{"rendered":"

\u7f8e\u570b\u9818\u5148\u7684\u57fa\u56e0\u7de8\u8f2f\u516c\u53f8CRISPR Therapeutics AG\uff08NASDAQ: CRSP\uff09<\/a>\u80a1\u50f92019\u5e74\u4e0a\u6f3252%\uff0c\u4f46\u8f03\u51762018\u5e74\u5275\u51fa\u7684\u7d00\u9304\u9ad8\u50f9\u4ecd\u4f4e40%\u3002\u4e0d\u904e\uff0c\u516c\u53f8\u767c\u5e03\u7684\u4e09\u5b63\u5831\u7684\u7576\u4e2d\uff0c\u7ba1\u7406\u5c64\u5f3a\u8abf\u4e86\u6709\u671b\u9a45\u52d5\u8a72\u751f\u7269\u79d1\u6280\u80a1\u80a1\u50f9\u518d\u6b21\u5275\u51fa\u65b0\u9ad8\u7684\u6578\u500b\u50ac\u5316\u5291\u3002<\/p>\n

1.\u00a0\u00a0 \u57fa\u56e0\u7de8\u8f2f\u9020\u8840\u5e79\u7d30\u80de\u7642\u6cd5CTX001\u7684\u7d50\u679c\u5373\u5c07\u516c\u5e03<\/h2>\n

\u4eca\u5e742\u6708\uff0cCRISPR Therapeutics\u806f\u5408\u798f\u6cf0\u88fd\u85e5Vertex Pharmaceuticals\uff08NASDAQ: VRTX\uff09<\/a>\u5c0d\u5916\u5ba3\u5e03\uff0c\u57fa\u56e0\u7de8\u8f2f\u9020\u8840\u5e79\u7d30\u80de\u7642\u6cd5CTX001\u5553\u52d5\u81e8\u5e8a\u8a66\u9a57\uff0c\u76ee\u524d\u5df2\u6709\u9996\u4f8b\u60a3\u8005\u63a5\u53d7\u6cbb\u7642\u3002\u5169\u5bb6\u516c\u53f8\u5206\u5225\u958b\u5c55\u5169\u9805\u8a66\u9a57\u8a55\u4f30CTX001\uff0c\u4e00\u9805\u8a66\u9a57\u7684\u53d7\u8a66\u8005\u662f\u8f38\u8840\u4f9d\u8cf4\u6027\u5730\u4e2d\u6d77\u8ca7\u8840\uff08TDT\uff09\u60a3\u8005\uff0c\u53e6\u4e00\u9805\u662f\u56b4\u91cd\u7684\u942e\u72c0\u7d30\u80de\u75c5\uff08SCD\uff09\u60a3\u8005\u3002\u9019\u5169\u7a2e\u75be\u75c5\u5747\u7531\u8840\u7d05\u86cb\u767d\u57fa\u56e0\u7f3a\u9677\u5c0e\u81f4\uff0c\u60a3\u8005\u9700\u8981\u983b\u7e41\u9032\u884c\u8f38\u8840\u3002<\/p>\n

CTX001\u901a\u904e\u526a\u5207BCL11A\u57fa\u56e0\uff08\u6291\u5236\u80ce\u5152\u8840\u7d05\u86cb\u767d\u7684\u7523\u751f\uff09\u5be6\u73fe\u6cbb\u7642\u76ee\u7684\uff0c\u8a66\u9a57\u4eba\u54e1\u5f9e\u60a3\u8005\u9ad4\u5167\u53d6\u51fa\u9020\u8840\u5e79\u7d30\u80de\uff0c\u5728\u9ad4\u5916\u5c0d\u5176\u9032\u884c\u7de8\u8f2f\uff0c\u7136\u5f8c\u518d\u6ce8\u5165\u60a3\u8005\u9ad4\u5167\uff0c\u7de8\u8f2f\u5f8c\u7684\u5e79\u7d30\u80de\u80fd\u591f\u751f\u6210\u8db3\u591f\u80ce\u5152\u8840\u7d05\u86cb\u767d\u7684\u7d05\u7d30\u80de\uff0c\u5f9e\u800c\u51cf\u5c11\u60a3\u8005\u5c0d\u4e8e\u8f38\u8840\u7684\u4f9d\u8cf4\u3002<\/p>\n

CRISPR Therapeutics\u5c07\u5728\u5e74\u5e95\u524d\uff0c\u6700\u6709\u53ef\u80fd\u662f\u572812\u6708\u8209\u884c\u7684\u7f8e\u570b\u8840\u6db2\u5b78\u6703\uff08ASH\uff09\u5e74\u6703\u4e0a\u516c\u5e03CTX001\u7684\u521d\u671f\u7d50\u679c\u3002\u5982\u679c\u8a66\u9a57\u7d50\u679c\u76f8\u8f03Bluebird bio Inc\uff08NASDAQ: BLUE\uff09<\/a>\u7684\u65b0\u578b\u57fa\u56e0\u7642\u6cd5LentiGlobin\u5177\u5099\u7af6\u722d\u529b\uff0cCRISPR Therapeutics\u6709\u671b\u6210\u7232\u4eca\u5e74\u751f\u7269\u79d1\u6280\u9818\u57df\u7684\u4e00\u96bb\u5927\u725b\u80a1\u3002<\/p>\n

2.\u00a0\u00a0 \u540c\u7a2e\u5f02\u9ad4CAR-T\u7d30\u80de\u7642\u6cd5\uff1a\u764c\u75c7\u6cbb\u7642\u7684\u65b0\u9014\u5f91<\/h2>\n

CRISPR Therapeutics\u7684\u540c\u7a2e\u5f02\u9ad4CAR-T\u7d30\u80de\u7642\u6cd5CTX110\u5df2\u7d93\u958b\u59cb\u6cbb\u7642\u764c\u75c7\u60a3\u8005\u3002\u8ddf\u5409\u5229\u5fb7\u79d1\u5b78Gilead Sciences\uff08NASDAQ: GILD\uff09<\/a>\u7684CAR-T\u7d30\u80de\u7642\u6cd5Yescarta\u4e0d\u540c\u7684\u662f\uff0c\u5118\u7ba1\u5169\u7a2e\u7642\u6cd5\u5747\u7531\u9776\u5411CD19\u7684\u514d\u75ab\u7d30\u80de\u88fd\u6210\uff0c\u4f46Yescarta\u5c6c\uffff\u81ea\u9ad4\u7d30\u80de\u7642\u6cd5\uff0c\u6210\u672c\u6548\u76ca\u4e0d\u9ad8\uff0c\u92b7\u552e\u60c5\u51b5\u4e5f\u4e0d\u5982\u4eba\u610f\u3002<\/p>\n

\u5982\u679cCTX110\u7684\u7d50\u679c\u7a4d\u6975\uff0c\u8a72\u540c\u7a2e\u5f02\u9ad4\u7d30\u80de\u7642\u6cd5\u5c0d\u4e8eCRISPR\u80a1\u50f9\u7684\u63d0\u632f\u4f5c\u7528\u751a\u81f3\u8981\u9ad8\u4e8eCTX001\uff0c\u539f\u56e0\u6709\u4e8c\uff1a\u8ddfCTX001\u4e0d\u540c\u7684\u662f\uff0cCRISPR Therapeutics\u5b8c\u5168\u638c\u63e1\u764c\u75c7\u9805\u76ee\uff0c\u56e0\u6b64\u7121\u9700\u8ddf\u798f\u6cf0\u88fd\u85e5\u6216\u5176\u4ed6\u88fd\u85e5\u5546\u5206\u4eab\u5229\u6f64\u3002\u53e6\u5916\uff0c\u9776\u5411BCMA\u7684CTX120\u7684\u81e8\u5e8a\u8a66\u9a57\u5c07\u4e8e2020\u5e74\u4e0a\u534a\u5e74\u5553\u52d5\uff0c\u7b2c\u4e09\u6b3e\u9776\u5411CD70\u7684\u540c\u7a2e\u5f02\u9ad4\u7d30\u80de\u7642\u6cd5\u4e5f\u5c07\u5728\u4e0d\u4e45\u4e4b\u5f8c\u9032\u5165\u81e8\u5e8a\u8a66\u9a57\u3002<\/p>\n

3.\u00a0\u00a0 \u540c\u7a2e\u5f02\u9ad4\u5e79\u7d30\u80de\u7642\u6cd5\uff1a\u7cd6\u5c3f\u75c5\u6cbb\u7642\u7684\u65b0\u9014\u5f91<\/h2>\n

\u53bb\u5e749\u6708\uff0cCRISPR\u548c\u79c1\u4eba\u516c\u53f8ViaCyte\u9054\u6210\u6230\u7565\u5408\u4f5c\uff0c\u96d9\u65b9\u5c07\u5171\u540c\u958b\u767c\u6cbb\u7642\u4e00\u578b\u7cd6\u5c3f\u75c5\u7684\u540c\u7a2e\u5f02\u9ad4\u5e79\u7d30\u80de\u7523\u54c1\u3002\u76ee\u524d\u5168\u7403\u7bc4\u570d\u5167\u7684\u4e00\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u4eba\u6578\u8d85\u904e2000\u842c\uff0c\u7531\u4e8e\u80f0\u5cf6\u7d30\u80de\u7684\u529f\u80fd\u7834\u58de\uff0c\u60a3\u8005\u9700\u8981\u9577\u671f\u4f9d\u8cf4\u80f0\u5cf6\u7d20\u9032\u884c\u6cbb\u7642\u3002\u5c07\u5065\u5eb7\u500b\u9ad4\u7684\u80f0\u5cf6\u7d20\u751f\u6210\u7d30\u80de\u79fb\u690d\u81f3\u60a3\u8005\u7684\u80f0\u817a\uff0c\u9019\u662f\u4e00\u689d\u53ef\u884c\u7684\u6cbb\u7642\u65b9\u6848\uff0c\u4f46\u7531\u4e8e\u5b58\u5728\u6392\u65a5\u53cd\u61c9\uff0c\u9019\u6a23\u7684\u624b\u8853\u76f8\u7576\u7f55\u898b\u3002<\/p>\n

\u6b64\u6b21\u958b\u767c\u7684\u9019\u7a2e\u5e79\u7d30\u80de\u80fd\u591f\u751f\u6210\u80f0\u5cf6\u7d20\u548c\u8868\u9762\u86cb\u767dPD-L1\uff0c\u540c\u6642\u80fd\u591f\u9003\u9038\u4eba\u9ad4\u7684\u514d\u75ab\u7cfb\u7d71\u653b\u64ca\u3002\u5728\u57f9\u990a\u76bf\u7576\u4e2d\uff0c\u9019\u4e9b\u5e79\u7d30\u80de\u4f3c\u4e4e\u80fd\u591f\u9032\u884c\u81ea\u6211\u4fdd\u8b77\u3002\u5982\u679c\u5728\u8f49\u79fb\u81f3\u80f0\u817a\u4e2d\u4e4b\u5f8c\u4ecd\u5177\u5099\u9019\u4e00\u80fd\u529b\uff0cCRISPR\u5c07\u80fd\u591f\u529f\u80fd\u6027\u6cbb\u6108\u4e00\u578b\u7cd6\u5c3f\u75c5\u3002<\/p>\n

\u9700\u8981\u6ce8\u610f\u7684\u98a8\u96aa<\/h2>\n

\u5be6\u9a57\u5ba4\u8b49\u660e\u67d0\u7a2e\u7642\u6cd5\u7b26\u5408\u9810\u671f\u53ea\u662f\u7b2c\u4e00\u6b65\uff0c\u5e77\u4e0d\u4ee3\u8868\u5c07\u5728\u4eba\u9ad4\u81e8\u5e8a\u8a66\u9a57\u4e2d\u4e5f\u80fd\u53d6\u5f97\u6210\u529f\u3002\u6b64\u5916\uff0c\u6295\u8cc7\u8005\u9700\u8981\u505a\u597dCVX001\u548cCVX110\u7684\u65e9\u671f\u7d50\u679c\u4e0d\u5982\u4eba\u610f\u7684\u5fc3\u7406\u6e96\u5099\uff0c\u56e0\u7232\u627e\u5230\u5408\u9069\u6578\u91cf\u7684\u7d30\u80de\u7528\u4e8e\u8a66\u9a57\u6027\u6cbb\u7642\u662f\u4e00\u7a2e\u4e0d\u65b7\u8a66\u932f\u7684\u904e\u7a0b\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u7f8e\u570b\u9818\u5148\u7684\u57fa\u56e0\u7de8\u8f2f\u516c\u53f8CRISPR Therapeutics AG\uff08NASDAQ: CRSP\uff09\u80a1\u50f92019\u5e74\u4e0a […]<\/p>\n","protected":false},"author":27,"featured_media":300395,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[1522,431],"tags":[809,927,563,644,564],"class_list":["post-300407","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-1522","category-trends-strategies-zh-hant","tag-809","tag-927","tag--zh-hant","tag-644","tag-564","sectors-life-science-zh-hant","locations-us-zh-hant","exchange-nasdaq-zh-hant"],"acf":[],"_links":{"self":[{"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/posts\/300407","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/users\/27"}],"replies":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/comments?post=300407"}],"version-history":[{"count":0,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/posts\/300407\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/media\/300395"}],"wp:attachment":[{"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/media?parent=300407"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/categories?post=300407"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/tags?post=300407"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}