{"id":306815,"date":"2019-11-26T16:38:20","date_gmt":"2019-11-27T00:38:20","guid":{"rendered":"https:\/\/nai500.com\/blog\/2019\/11\/crispr-therapeutics-ctx001-%e5%9f%ba%e5%9b%a0%e7%bc%96%e8%be%91%e6%a6%82%e5%bf%b5%e8%82%a1\/"},"modified":"2019-11-26T16:38:40","modified_gmt":"2019-11-27T00:38:40","slug":"crispr-therapeutics-ctx001-%e5%9f%ba%e5%9b%a0%e7%b7%a8%e8%bc%af%e6%a6%82%e5%bf%b5%e8%82%a1","status":"publish","type":"post","link":"https:\/\/nai500.com\/zh-hant\/blog\/2019\/11\/crispr-therapeutics-ctx001-%e5%9f%ba%e5%9b%a0%e7%b7%a8%e8%bc%af%e6%a6%82%e5%bf%b5%e8%82%a1\/","title":{"rendered":"CTX001\u8a66\u9a57\u7d50\u679c\u7a4d\u6975\uff0cCRISPR Therapeutics\u662f\u76ee\u524d\u6700\u4f73\u7684\u57fa\u56e0\u7de8\u8f2f\u6982\u5ff5\u80a1\u55ce\uff1f"},"content":{"rendered":"

\u57fa\u56e0\u7de8\u8f2f\u516c\u53f8CRISPR Therapeutics AG\uff08NASDAQ: CRSP\uff09<\/a>\u6700\u8fd1\u767c\u5e03\u57fa\u56e0\u7de8\u8f2f\u9020\u8840\u5e79\u7d30\u80de\u7642\u6cd5CTX001\u7684\u8a66\u9a57\u7d50\u679c\u975e\u5e38\u7a4d\u6975\uff0c\u53e0\u52a0\u6b64\u524dOppenheimer\u5206\u6790\u5e2b\u8abf\u5347\u8a72\u80a1\u8a55\u7d1a\uff0c\u8a72\u80a1\u80a1\u50f9\u572811\u670819\u65e5\u7576\u5929\u66b4\u6f32\u8d85\u904e25%\u3002\u4e0d\u904e\uff0c\u6b64\u5f8cCRISPR\u56de\u5410\u591a\u6578\u6f32\u5e45\uff0c\u6700\u8fd1\u7684\u56de\u8abf\u662f\u6295\u8cc7\u8005\u9022\u4f4e\u8cb7\u5165\u9019\u53ea\u57fa\u56e0\u7de8\u8f2f\u6982\u5ff5\u80a1\u7684\u6a5f\u6703\u55ce\uff1f<\/p>\n

\u57fa\u56e0\u7de8\u8f2f\u85e5\u7269CTX001\u7684\u8a66\u9a57\u7d50\u679c<\/h2>\n

\u672c\u6708\u65e9\u4e9b\u6642\u5019\uff0cCRISPR\u767c\u5e03\u5019\u9078\u85e5\u7269CTX001\u7684\u7b2c\u4e00\u500b\u81e8\u5e8a\u8a66\u9a57\u6578\u64da\uff0c\u5176\u4e2d\u5305\u62ec\u4e00\u540d\u942e\u72c0\u7d30\u80de\u75c5\uff08SCD\uff09\u60a3\u8005\u4ee5\u53ca\u4e00\u540d\u8f38\u8840\u4f9d\u8cf4\u578b\u03b2\u5730\u4e2d\u6d77\u8ca7\u8840\u60a3\u8005\u7684\u7d50\u679c\u3002\u7d50\u679c\u986f\u793a\uff0c\u5169\u540d\u60a3\u8005\u5747\u5831\u544a\u4e3b\u8981\u75c7\u72c0\u5b8c\u5168\u6d88\u5931\u3002<\/p>\n

\u5177\u9ad4\u4f86\u770b\uff0c\u942e\u72c0\u7d30\u80de\u75c5\u60a3\u8005\u6b64\u524d\u6bcf\u5e74\u5e73\u5747\u767c\u751f7\u6b21\u8840\u7ba1\u5835\u585e\uff08\u8840\u7ba1\u9589\u585e\u5371\u6a5f\uff09\uff0c\u4f46\u5728\u6cbb\u7642\u76849\u500b\u6708\u671f\u9593\uff0c\u60a3\u8005\u6c92\u6709\u767c\u751f\u904e1\u6b21\u5835\u585e\u3002\u03b2\u5730\u4e2d\u6d77\u8ca7\u8840\u60a3\u8005\u6b64\u524d\u6bcf\u5e74\u5e73\u5747\u9700\u8981\u8f38\u884016.5\u6b21\uff0c\u4e0d\u904e\u5728\u63a5\u53d7CTX001\u6cbb\u7642\u5169\u5e74\u5f8c\uff0c\u9019\u4e00\u6578\u5b57\u964d\u81f3\u96f6\uff0c\u5373\u5b8c\u5168\u64fa\u812b\u4e86\u5c0d\u4e8e\u8f38\u8840\u7684\u4f9d\u8cf4\u3002<\/p>\n

\u8a66\u9a57\u7d50\u679c\u9084\u6709\u66f4\u591a\u7684\u7d30\u7bc0\uff0c\u4f46\u7c21\u55ae\u4f86\u8aaa\uff0c\u521d\u6b65\u7d50\u679c\u975e\u5e38\u4ee4\u4eba\u632f\u596e\u3002<\/p>\n

\u6f5c\u5728\u7684\u7af6\u722d\u5c0d\u624b<\/h2>\n

\u5118\u7ba1\u5230\u76ee\u524d\u7232\u6b62\uff0cCTX001\u7684\u8a66\u9a57\u7d50\u679c\u7a4d\u6975\uff0c\u4f46\u76f8\u8f03\u6b63\u8655\u4e8e\u958b\u767c\u904e\u7a0b\u4e2d\u7684\u5176\u4ed6\u7af6\u722d\u85e5\u7269\u9818\u5148\u512a\u52e2\u5e77\u6c92\u6709\u90a3\u9ebd\u660e\u986f\u3002\u8840\u6db2\u75c5\u662f\u57fa\u56e0\u7de8\u8f2f\u516c\u53f8\u4e3b\u653b\u7684\u4e00\u500b\u65b9\u5411\uff0c\u5176\u4e2dEditas Medicine Inc\uff08NASDAQ: EDIT\uff09<\/a>\u548cSangamo Therapeutics Inc\uff08NASDAQ: SGMO\uff09<\/a>\u90fd\u5728\u958b\u767c\u81ea\u5df1\u7684\u942e\u72c0\u7d30\u80de\u75c5\u548c\u03b2\u5730\u4e2d\u6d77\u8ca7\u8840\u6cbb\u7642\u65b9\u6cd5\u3002<\/p>\n

\u4eca\u5e74\u65e9\u4e9b\u6642\u5019\uff0cEditas\u7684\u942e\u72c0\u7d30\u80de\u75c5\u85e5\u7269EDIT-301\u986f\u793a\u4e0d\u932f\u7684\u81e8\u5e8a\u524d\u7d50\u679c\uff0c\u9810\u8a08\u5e74\u5e95\u524d\u5c07\u63d0\u4f9b\u66f4\u591a\u7684\u7814\u7a76\u4fe1\u606f\u3002\u4e0d\u904e\uff0c\u8ddfCRISPR\u4e0d\u540c\u7684\u662f\uff0cEditas\u7684\u65d7\u8266\u85e5\u7269\u5e77\u4e0d\u662f\u91dd\u5c0d\u8840\u6db2\u75c5\u7684EDIT-301\uff0c\u800c\u662f\u4e3b\u653b\u7f55\u898b\u5152\u7ae5\u773c\u75c5\u2014\u2014Leber\u5148\u5929\u6027\u9ed1\u6726\u7684EDIT-101\u3002Leber\u5148\u5929\u6027\u9ed1\u6726\u662f\u4e00\u7a2e\u56b4\u91cd\u7684\u907a\u50b3\u6027\u8996\u7db2\u819c\u8b8a\u6027\u75be\u75c5\uff0c\u5c0e\u81f4\u5b30\u5e7c\u5152\u5148\u5929\u6027\u76f2\u3002<\/p>\n

\u81f3\u4e8eSangamo\uff0c\u8a72\u516c\u53f8\u7684\u85e5\u7269\u7814\u767c\u7ba1\u7dab\u76f8\u7576\u5bec\uff0c\u5176\u4e2d\u5305\u62ec\u8655\u4e8e\u958b\u767c\u904e\u7a0b\u4e2d\u7684\u03b2\u5730\u4e2d\u6d77\u8ca7\u8840\u85e5\u7269ST-400\u548c\u942e\u72c0\u7d30\u80de\u75c5\u85e5\u7269BIVV-003\u3002\u4e0d\u904e\uff0c\u9019\u5169\u6b3e\u85e5\u7269\u4ecd\u8655\u4e8e\u81e8\u5e8a\u8a66\u9a57\u975e\u5e38\u521d\u671f\u7684\u968e\u6bb5\uff0c\u5176\u4e2d\u4e00\u9805\u7814\u7a76\u62db\u52df\u4e86\u5169\u540d\u60a3\u8005\u8a55\u4f30ST-400\u6cbb\u7642\u03b2-\u5730\u4e2d\u6d77\u8ca7\u8840\u3002\u521d\u671f\u6578\u64da\u9810\u8a08\u5c07\u4e8e\u5e74\u5e95\u524d\u51fa\u7210\uff0c\u751f\u7269\u79d1\u6280\u6295\u8cc7\u8005\u61c9\u7576\u4e88\u4ee5\u95dc\u6ce8\u3002<\/p>\n

\u4e0d\u904e\uff0c\u8ddfEditas\u985e\u4f3c\u7684\u662f\uff0cSangamo\u7684\u03b2\u5730\u4e2d\u6d77\u8ca7\u8840\u548c\u942e\u72c0\u7d30\u80de\u75c5\u7642\u6cd5\u5e77\u4e0d\u662f\u8a72\u516c\u53f8\u7684\u4e3b\u8981\u5019\u9078\u85e5\u7269\u3002\u76f8\u53cd\uff0c\u8a72\u516c\u53f8\u7684\u65d7\u8266\u7642\u6cd5\u662f\u7532\u578b\u8840\u53cb\u75c5\u85e5\u7269SB-525\u3002\u7532\u578b\u8840\u53cb\u75c5\u662f\u4e00\u7a2e\u7f55\u898b\u7684\u51fa\u8840\u6027\u75be\u75c5\uff0c\u81f4\u75c5\u539f\u56e0\u662f\u8840\u6f3f\u4e2d\u7684\u51dd\u8840\u56e0\u5b50VIII\u4e0d\u8db3\u3002<\/p>\n

CRISPR\u662f\u76ee\u524d\u6700\u4f73\u7684\u57fa\u56e0\u7de8\u8f2f\u6982\u5ff5\u80a1\u55ce\uff1f<\/h2>\n

CRISPR\u76ee\u524d\u662f\u5426\u662f\u7d55\u5c0d\u7684\u6700\u4f73\u57fa\u56e0\u7de8\u8f2f\u6982\u5ff5\u80a1\u9084\u5b58\u7591\u3002\u8a72\u516c\u53f8\u5728\u942e\u72c0\u7d30\u80de\u75c5\u548c\u03b2\u5730\u4e2d\u6d77\u8ca7\u8840\u6cbb\u7642\u9818\u57df\u9818\u8dd1\uff08\u672a\u4f86\u5e7e\u5e74\u9019\u5169\u500b\u9818\u57df\u7684\u5e02\u5834\u898f\u6a21\u4f30\u8a08\u5c07\u5206\u5225\u9054$35\u5104\u548c$55\u5104\uff09\u3002\u4e0d\u904e\uff0c\u5728\u5176\u4ed6\u6cbb\u7642\u9818\u57df\uff0c\u5176\u4ed6\u57fa\u56e0\u7de8\u8f2f\u516c\u53f8\u5177\u5099CRISPR\u6c92\u6709\u7684\u512a\u52e2\u3002Sangamo\u7684\u8840\u53cb\u75c5\u6cbb\u7642\u5c31\u662f\u4e00\u500b\u6975\u597d\u7684\u4f8b\u5b50\uff1a\u8a72\u9818\u57df\u7684\u5e02\u5834\u898f\u6a21\u9810\u8a08\u52302025\u5e74\u5c07\u9054$148\u5104\u3002<\/p>\n

\u8207\u6b64\u540c\u6642\uff0c\u6709\u4e9b\u6bba\u5165\u57fa\u56e0\u7de8\u8f2f\u9818\u57df\u7684\u88fd\u85e5\u516c\u53f8\u5df2\u7d93\u958b\u59cb\u5f03\u7528CRISPR Therapeutics\u958b\u767c\u7684CRISPR\/Cas9\u57fa\u56e0\u7de8\u8f2f\u5de5\u5177\u3002\u8afe\u548c\u8afe\u5fb7Novo Nordisk\uff08NYSE: NVO\uff09<\/a>\u6700\u8fd1\u5c31\u5ba3\u5e03\uff0c\u8a72\u516c\u53f8\u6c92\u6709\u9078\u7528CRISPR\/Cas9\u6280\u8853\uff0c\u800c\u5c07\u91c7\u7528Bluebird bio Inc\uff08NASDAQ: BLUE\uff09<\/a>\u958b\u767c\u7684\u53e6\u4e00\u7a2e\u57fa\u4e8emRNA\u7684\u6280\u8853megaTALs\u3002\u6709\u7814\u7a76\u986f\u793a\uff0c\u9019\u4e00\u66f4\u65b0\u7684\u57fa\u56e0\u7de8\u8f2f\u6280\u8853\u76f8\u8f03CRISPR\/Cas9\u6e96\u78ba\u6027\u66f4\u9ad8\u3002<\/p>\n

\u76ee\u524d\u54ea\u53ea\u57fa\u56e0\u7de8\u8f2f\u500b\u80a1\u662f\u6700\u4f73\u7684\u6295\u8cc7\u9078\u64c7\uff0c\u9019\u5f88\u96e3\u8aaa\uff0c\u4f46\u50c5\u5f9e\u942e\u72c0\u7d30\u80de\/\u03b2\u5730\u4e2d\u6d77\u8ca7\u8840\u7684\u8a66\u9a57\u7d50\u679c\u51fa\u767c\uff0cCRISPR Therapeutics\u7684\u512a\u52e2\u9084\u662f\u6bd4\u8f03\u7a81\u51fa\u7684\u3002\u4e0d\u904e\uff0c\u6295\u8cc7\u8005\u6700\u597d\u9084\u662f\u61c9\u7576\u91c7\u53d6\u9ce5\u69cd\u7b56\u7565\uff0c\u5373\u591a\u5143\u5316\u6301\u80a1\uff0c\u5206\u6563\u5c0f\u984d\u6301\u6709\u5305\u62ecCRISPR\u3001Editas\u548cSangamo\u7b49\u982d\u90e8\u7684\u57fa\u56e0\u7de8\u8f2f\u6982\u5ff5\u80a1\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u57fa\u56e0\u7de8\u8f2f\u516c\u53f8CRISPR Therapeutics AG\uff08NASDAQ: CRSP\uff09\u6700\u8fd1\u767c\u5e03\u57fa\u56e0\u7de8\u8f2f\u9020\u8840\u5e79\u7d30\u80de […]<\/p>\n","protected":false},"author":27,"featured_media":306801,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[1522,431],"tags":[809,927,563,564],"class_list":["post-306815","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-1522","category-trends-strategies-zh-hant","tag-809","tag-927","tag--zh-hant","tag-564","sectors-life-science-zh-hant","locations-us-zh-hant","exchange-nasdaq-zh-hant","exchange-nyse-zh-hant"],"acf":[],"_links":{"self":[{"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/posts\/306815","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/users\/27"}],"replies":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/comments?post=306815"}],"version-history":[{"count":0,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/posts\/306815\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/media\/306801"}],"wp:attachment":[{"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/media?parent=306815"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/categories?post=306815"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/tags?post=306815"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}