{"id":309298,"date":"2019-12-10T22:47:14","date_gmt":"2019-12-11T06:47:14","guid":{"rendered":"https:\/\/nai500.com\/blog\/2019\/12\/cstone-announces-enrollment-target-reached-in-the-global-phase-iii-voyager-trial-of-avapritinib-in-chinese-patients-with-third-line-gist\/"},"modified":"2019-12-10T22:47:55","modified_gmt":"2019-12-11T06:47:55","slug":"%e5%9f%ba%e7%9f%b3%e8%97%a5%e6%a5%ad%e5%85%a8%e7%90%83%e4%b8%89%e6%9c%9f-voyager-%e8%a9%a6%e9%a9%97%e5%9c%a8%e8%8f%af%e5%ae%8c%e6%88%90%e6%82%a3%e8%80%85%e5%85%a5%e7%b5%84","status":"publish","type":"post","link":"https:\/\/nai500.com\/zh-hant\/blog\/2019\/12\/%e5%9f%ba%e7%9f%b3%e8%97%a5%e6%a5%ad%e5%85%a8%e7%90%83%e4%b8%89%e6%9c%9f-voyager-%e8%a9%a6%e9%a9%97%e5%9c%a8%e8%8f%af%e5%ae%8c%e6%88%90%e6%82%a3%e8%80%85%e5%85%a5%e7%b5%84\/","title":{"rendered":"\u57fa\u77f3\u85e5\u696d\u5168\u7403\u4e09\u671fVOYAGER\u8a66\u9a57\u5728\u83ef\u5b8c\u6210\u60a3\u8005\u5165\u7d44"},"content":{"rendered":"<p>\u57fa\u77f3\u85e5\u696d\uff08\u9999\u6e2f\u4ea4\u6613\u6240\uff1a2616\uff09\u4eca\u5929\u5ba3\u4f48\uff0c\u7531\u57fa\u77f3\u85e5\u696d\u5408\u4f5c\u5925\u4f34Blueprint Medicines\u958b\u767c\u7684\u5728\u7814\u7522\u54c1avapritinib\uff0c\u5728\u4e00\u9805\u6b63\u5728\u9032\u884c\u7684\u5168\u7403III\u671f\u81e8\u5e8a\u7814\u7a76VOYAGER\u4e2d\u5b8c\u6210\u4e86\u4e2d\u570b\u60a3\u8005\u5165\u7d44\u76ee\u6a19\u3002\u6b64\u5916\uff0cVOYAGER\u8a66\u9a57\u7684\u5168\u7403\u60a3\u8005\u5165\u7d44\u76ee\u6a19\u4e5f\u5df2\u9054\u6210\u3002VOYAGER\u7814\u7a76\u65e8\u5728\u8a55\u4f30\u76f8\u8f03\u76ee\u524d\u7684\u6a19\u6e96\u4e09\u7dda\u6cbb\u7642\u85e5\u7269\u745e\u6208\u975e\u5c3c\uff0cavapritinib\u7528\u65bc\u4e09\u7dda\u6216\u56db\u7dda\u665a\u671f\u80c3\u8178\u9053\u9593\u8cea\u7624\uff08GIST\uff09\u60a3\u8005\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\u3002<\/p>\n<p>Blueprint Medicines\u9810\u8a08\u5c07\u57282020\u5e74\u7b2c\u4e8c\u5b63\u5ea6\u5831\u544a\u6700\u91cd\u8981\u7684VOYAGER\u8a66\u9a57\u6578\u64da\u30022019\u5e748\u6708\uff0c\u7f8e\u570bFDA\u5df2\u63a5\u53d7Blueprint Medicines\u95dc\u65bcavapritinib\u7528\u65bc\u7121\u8ad6\u4e4b\u524d\u662f\u5426\u63a5\u53d7\u904e\u6cbb\u7642\u7684\u3001\u651c\u5e36PDGFRA\u5916\u986f\u5b5018\u7a81\u8b8a\u7684GIST\uff0c\u53ca\u7528\u65bc\u56db\u7ddaGIST\u7684\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\u3002\u6839\u64da\u521d\u6b65\u5be9\u6279\u60c5\u6cc1\uff0cBlueprint Medicines\u9810\u8a08\u65bc2020\u5e74\u4e0b\u534a\u5e74\u5411FDA\u905e\u4ea4\u65b0\u9069\u61c9\u75c7\u4e0a\u5e02\u7533\u8acb\uff0c\u7528\u65bc\u4e09\u7ddaGIST\u6cbb\u7642\u3002\u57fa\u77f3\u85e5\u696d\u4e5f\u8a08\u5283\u57282020\u5e74\u4e0b\u534a\u5e74\u540c\u6b65\u5411\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u905e\u4ea4avapritnib\u7528\u65bc\u4e09\u7ddaGIST\u6cbb\u7642\u7684\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\u3002<\/p>\n<p>GIST\u662f\u6700\u5e38\u898b\u7684\u80c3\u8178\u9053\u9593\u8cea\u816b\u7624\uff0c\u572850\u81f380\u6b72\u7684\u60a3\u8005\u4e2d\u6700\u666e\u904d\u3002\u6240\u6709GIST\u75c5\u4f8b\u4e2d\uff0c\u7d0490\uff05\u8207KIT\u548cPDGFRA\u916a\u6c28\u9178\u6fc0\u9176\u7a81\u8b8a\u5f15\u8d77\u7684\u7d30\u80de\u751f\u9577\u5931\u8abf\u6709\u95dc\u3002\u76ee\u524d\u7684\u6a19\u6e96\u4e09\u7ddaGIST\u6cbb\u7642\u85e5\u7269regorafenib\u7684\u73fe\u6709\u6578\u64da\u986f\u793a\uff0c\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\u70ba4.8\u500b\u6708\uff0c\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\u50c5\u7d04\u70ba5\uff05\u3002\u5c0d\u65bc\u4e09\u7dda\u6cbb\u7642\u5931\u6557\u7684GIST\u60a3\u8005\uff0c\u76ee\u524d\u5c1a\u7121\u6279\u51c6\u7684\u6cbb\u7642\u65b9\u6cd5\u3002\u56e0\u6b64\uff0c\u4e09\u7dda\u53ca\u4ee5\u5f8c\u7684GIST\u60a3\u8005\u6709\u5f88\u9ad8\u7684\u672a\u6eff\u8db3\u81e8\u5e8a\u9700\u6c42\u3002<\/p>\n<p>Avapritinib\u662f\u4e00\u7a2e\u5728\u7814\u7684\u53e3\u670d\u3001\u5f37\u6548\u3001\u9ad8\u9078\u64c7\u6027\u7684KIT\u548cPDGFRA\u6291\u5236\u5291\u3002\u5df2\u516c\u4f48\u7684\u81e8\u5e8a\u8a66\u9a57\u6578\u64da\u986f\u793a\uff0cavapritinib\u5728PDGFRA\u5916\u986f\u5b5018\u7a81\u8b8a\uff08\u5305\u62ecD842V\u7a81\u8b8a\uff09GIST\u548c\u56db\u7ddaGIST\u60a3\u8005\u4e2d\u5747\u986f\u793a\u51fa\u4ee4\u4eba\u9f13\u821e\u7684\u6297\u816b\u7624\u6d3b\u6027\u548c\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u76ee\u524d\u91dd\u5c0d\u9019\u5169\u985e\u60a3\u8005\u5c1a\u7121\u6709\u6548\u6cbb\u7642\u65b9\u6cd5\u3002<\/p>\n<p>\u57fa\u77f3\u85e5\u696d\u8463\u4e8b\u9577\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u6c5f\u752f\u8ecd\u535a\u58eb\u8868\u793a\uff1a\u201c\u5f88\u9ad8\u8208\u770b\u5230VOYAGER\u5168\u7403III\u671f\u7814\u7a76\u4e2d\u570b\u60a3\u8005\u5165\u7d44\u6bd4\u6211\u5011\u9810\u671f\u66f4\u5feb\u5b8c\u6210\uff0c\u9019\u4e5f\u8b93\u6211\u5011\u611f\u53d7\u5230\u4e86\u4e2d\u570bGIST\u60a3\u8005\u6025\u5207\u7684\u81e8\u5e8a\u9700\u6c42\u3002\u96a8\u8457\u8d99\u840d\u5973\u58eb\u6b63\u5f0f\u52a0\u76df\u57fa\u77f3\u85e5\u696d\uff0c\u51fa\u4efb\u5927\u4e2d\u83ef\u5340\u7e3d\u7d93\u7406\u517c\u5546\u696d\u5316\u8ca0\u8cac\u4eba\uff0c\u76f8\u4fe1\u9019\u4f4d\u66fe\u4e3b\u5c0e\u904e\u591a\u6b3e\u77e5\u540d\u85e5\u7269\u4e0a\u5e02\u7684\u8cc7\u6df1\u91ab\u85e5\u884c\u696d\u7d93\u7406\u4eba\u5c07\u9032\u4e00\u6b65\u52a9\u63a8\u516c\u53f8\u5546\u696d\u5316\u9032\u7a0b\u3002\u6211\u5c0d\u5305\u62ecavapritinib\u5728\u5167\u7684\u591a\u6b3e\u85e5\u7269\u5728\u4e2d\u570b\u6210\u529f\u4e0a\u5e02\u5145\u6eff\u4e86\u4fe1\u5fc3\u3002\u201d<\/p>\n<p>\u82f1\u6587\u4f86\u6e90\uff1aBiospace<\/p>\n","protected":false},"excerpt":{"rendered":"<p>CStone Pharmaceuticals (&#8220;CStone&#8221; or the &#8220;Company&#8221;, HKEX: 2616) today announced that the on-going, global Phase III VOYAGER clinical trial of avapritinib, an investigational drug discovered by CStone&#8217;s partner, Blueprint Medicines, has completed target patient enrollment in China. <\/p>\n","protected":false},"author":9,"featured_media":309292,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[426],"tags":[927,563,564],"class_list":["post-309298","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-market-news-zh-hant","tag-927","tag--zh-hant","tag-564","sectors-life-science-zh-hant","locations-china-zh-hant","locations-us-zh-hant"],"acf":[],"_links":{"self":[{"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/posts\/309298","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/comments?post=309298"}],"version-history":[{"count":0,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/posts\/309298\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/media\/309292"}],"wp:attachment":[{"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/media?parent=309298"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/categories?post=309298"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/tags?post=309298"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}