{"id":310191,"date":"2019-12-17T21:46:04","date_gmt":"2019-12-18T05:46:04","guid":{"rendered":"https:\/\/nai500.com\/blog\/2019\/12\/transthera\/"},"modified":"2019-12-17T21:46:40","modified_gmt":"2019-12-18T05:46:40","slug":"%e8%97%a5%e6%8d%b7%e5%ae%89%e5%ba%b7%e7%8d%b2fda%e6%89%b9%e5%87%86%ef%bc%8c%e9%96%8b%e5%95%9f%e5%85%a8%e7%90%83%e8%87%a8%e5%ba%8a%e8%a9%a6%e9%a9%97","status":"publish","type":"post","link":"https:\/\/nai500.com\/zh-hant\/blog\/2019\/12\/%e8%97%a5%e6%8d%b7%e5%ae%89%e5%ba%b7%e7%8d%b2fda%e6%89%b9%e5%87%86%ef%bc%8c%e9%96%8b%e5%95%9f%e5%85%a8%e7%90%83%e8%87%a8%e5%ba%8a%e8%a9%a6%e9%a9%97\/","title":{"rendered":"\u85e5\u6377\u5b89\u5eb7\u7372FDA\u6279\u51c6\uff0c\u958b\u555f\u5168\u7403\u81e8\u5e8a\u8a66\u9a57"},"content":{"rendered":"<p>\u5357\u4eac\u85e5\u6377\u5b89\u5eb7\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\u5ba3\u4f48\uff0c\u516c\u53f8\u81ea\u4e3b\u7814\u767c\u7684\u91dd\u5c0d\u6162\u6027\u5fc3\u529b\u8870\u7aed\u7684\u65b0\u578b\u5c0f\u5206\u5b50\u85e5\u7269TT-00920\u7372\u5f97\u7f8e\u570bFDA IND\u81e8\u5e8a\u8a66\u9a57\u6279\u51c6\u3002TT-00920\u662f\u4e00\u7a2e\u65b0\u578b\u7684\u78f7\u9178\u4e8c\u916f\u91769\uff08PDE 9\uff09\u5c0f\u5206\u5b50\u6291\u5236\u5291\uff0c\u7528\u65bc\u6cbb\u7642\u6162\u6027\u5fc3\u529b\u8870\u7aed\u3002\u85e5\u6377\u5b89\u5eb7\u5c07\u555f\u52d51\u671f\u81e8\u5e8a\u8a66\u9a57\uff0c\u4ee5\u8a55\u4f30TT-00920\u5728\u5065\u5eb7\u5fd7\u9858\u8005\u4e2d\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001\u85e5\u4ee3\u52d5\u529b\u5b78\u548c\u85e5\u6548\u5b78\u3002\u8a72\u8a66\u9a57\u9810\u8a08\u65bc2020\u5e74\u521d\u958b\u59cb\u3002<\/p>\n<p>\u85e5\u6377\u5b89\u5eb7\u5275\u59cb\u4eba\u517c\u9996\u5e2d\u57f7\u884c\u5b98Frank Wu\u535a\u58eb\u8868\u793a\uff1a\u201c IND\u6279\u51c6TT-00920\u662f\u85e5\u6377\u5b89\u5eb7\u7684\u91cd\u8981\u91cc\u7a0b\u7891\u3002\u6211\u5011\u76f8\u4fe1\uff0cTT-00920\u6709\u671b\u6210\u70ba\u60a3\u6709\u6162\u6027\u5fc3\u529b\u8870\u7aed\uff0c\u5c24\u5176\u662fHFpEF\uff08\u5c04\u8840\u5206\u6578\u6301\u7e8c\u5347\u9ad8\u7684\u5fc3\u529b\u8870\u7aed\uff09\u7684\u6162\u6027\u60a3\u8005\u7684\u65b0\u7684\u8f49\u5316\u6cbb\u7642\u9078\u64c7\uff0cHFpEF\u662f\u5fc3\u529b\u8870\u7aed\u7684\u4e3b\u8981\u5f62\u5f0f\uff0c\u6c92\u6709\u53ef\u4ee5\u6539\u8b8a\u75be\u75c5\u7684\u6cbb\u7642\u9078\u64c7\u3002\u6211\u5011\u671f\u5f85\u8207\u60a3\u8005\u548c\u91ab\u751f\u5408\u4f5c\uff0c\u8a55\u4f30TT-00920\u5728\u81e8\u5e8a\u4e2d\u7684\u6f5b\u529b\u3002\u201d<\/p>\n<p>TT-00920\u662f\u4e00\u7a2e\u7528\u65bc\u7814\u7a76\u6162\u6027\u5fc3\u529b\u8870\u7aed\u7684\u7814\u7a76\u6027\uff0c\u9ad8\u6548\u548c\u9078\u64c7\u6027PDE9\u6291\u5236\u5291\u3002PDE9\u86cb\u767d\u5e72\u64fe\u4eba\u9ad4\u4e2d\u548c\u5fc3\u81df\u58d3\u529b\u6240\u5fc5\u9700\u7684\u5929\u7136\u201c\u5236\u52d5\u201d\u7cfb\u7d71\uff0c\u4e26\u4e14\u5728\u5fc3\u529b\u8870\u7aed\uff08\u7279\u5225\u662fHFpEF\u4e2d\uff09\u65b9\u9762\u8868\u73fe\u51fa\u660e\u986f\u7684\u5347\u9ad8\u3002\u7528TT-00920\u6291\u5236PDE9\u53ef\u6062\u5fa9\u5fc3\u81df\u8870\u7aed\u6642\u529f\u80fd\u5931\u8abf\u7684\u5fc3\u81df\u4fdd\u8b77\u6a5f\u5236\u3002\u4ee4\u4eba\u4fe1\u670d\u7684\u81e8\u5e8a\u524d\u6578\u64da\u8868\u660e\uff0cTT-00920\u5728\u5fc3\u529b\u8870\u7aed\u4e2d\u53ef\u986f\u8457\u589e\u5f37\u5fc3\u81df\u529f\u80fd\u4e26\u9006\u8f49\u5fc3\u5ba4\u91cd\u69cb\u3002<\/p>\n<p>\u85e5\u6377\u5b89\u5eb7\u6210\u7acb\u65bc2016\u5e74\uff0c\u662f\u4e00\u5bb6\u81e8\u5e8a\u968e\u6bb5\u7684\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u81f4\u529b\u65bc\u958b\u767c\u5275\u65b0\u7642\u6cd5\uff0c\u4ee5\u6cbb\u7642\u5305\u62ec\u764c\u75c7\u3001\u5fc3\u8840\u7ba1\u75be\u75c5\u548c\u708e\u6027\u75be\u75c5\u7b49\u4e3b\u8981\u672a\u6eff\u8db3\u91ab\u7642\u9700\u6c42\u7684\u75be\u75c5\u3002TT-00920\u662f\u8a72\u516c\u53f8\u9032\u5165\u5168\u7403\u81e8\u5e8a\u958b\u767c\u7684\u7b2c\u4e8c\u500b\u5275\u65b0\u5019\u9078\u85e5\u7269\u3002<\/p>\n<p>\u82f1\u6587\u4f86\u6e90\uff1aBiospace<\/p>\n","protected":false},"excerpt":{"rendered":"<p>TransThera Biosciences Co. 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