{"id":314212,"date":"2020-01-23T22:47:16","date_gmt":"2020-01-24T06:47:16","guid":{"rendered":"https:\/\/nai500.com\/blog\/2020\/01\/ascletis-received-approval-of-clinical-trials-in-hbv-patients-for-asc22\/"},"modified":"2020-01-23T22:47:57","modified_gmt":"2020-01-24T06:47:57","slug":"%e6%ad%8c%e7%a6%ae%e8%a3%bd%e8%97%a5-asc22-%e6%9c%89%e6%9c%9b%e6%88%90%e7%82%ba-hbv-%e4%b8%80%e6%b5%81%e5%85%8d%e7%96%ab%e7%99%82%e6%b3%95","status":"publish","type":"post","link":"https:\/\/nai500.com\/zh-hant\/blog\/2020\/01\/%e6%ad%8c%e7%a6%ae%e8%a3%bd%e8%97%a5-asc22-%e6%9c%89%e6%9c%9b%e6%88%90%e7%82%ba-hbv-%e4%b8%80%e6%b5%81%e5%85%8d%e7%96%ab%e7%99%82%e6%b3%95\/","title":{"rendered":"\u6b4c\u79ae\u88fd\u85e5ASC22\u6709\u671b\u6210\u70baHBV\u4e00\u6d41\u514d\u75ab\u7642\u6cd5"},"content":{"rendered":"<p>\u6b4c\u79ae\u88fd\u85e5(Ascletis, 1672.HK)\u5ba3\u4f48\uff0c\u5176\u76ae\u4e0b\u6ce8\u5c04PD-L1\u6297\u9ad4ASC22\u7372\u5f97\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u5728\u6162\u6027\u4e59\u809d\uff08HBV\uff09\u60a3\u8005\u4e2d\u958b\u5c55\u81e8\u5e8a\u8a66\u9a57\u7684\u6279\u51c6\u3002ASC22\u662f\u5168\u7403\u9996\u500b(first-in-class)\u88ab\u6279\u51c6\u5728\u6162\u6027\u4e59\u809d\u60a3\u8005\u4e2d\u958b\u5c55\u81e8\u5e8a\u8a66\u9a57\u7684\u76ae\u4e0b\u6ce8\u5c04PD-L1\u6297\u9ad4\u3002<\/p>\n<p>\u7531\u65bc\u4e59\u809d\u75c5\u6bd2\u611f\u67d3\u4e2d\u7684T\u7d30\u80de\u8870\u7aed\u662f\u514d\u75ab\u8010\u53d7\u7684\u91cd\u8981\u56e0\u7d20\uff0c\u56e0\u6b64\u963b\u65b7PD-1 \/ PD-L1\u9014\u5f91\u53ef\u80fd\u662f\u6539\u5584\u7279\u7570\u6027T\u7d30\u80de\u529f\u80fd\u4e26\u6709\u6548\u6cbb\u7652\u6162\u6027\u4e59\u578b\u809d\u708e\u7684\u6709\u6548\u514d\u75ab\u7642\u6cd5\u3002\u5168\u7403\u67092.57\u5104\u4eba\u611f\u67d3HBV\uff0c\u5176\u4e2d\u5305\u62ec\u4e2d\u570b\u76848600\u842c\u60a3\u8005\u3002<\/p>\n<p>\u9664\u4e86ASC22\uff0c\u6b4c\u79ae\u88fd\u85e5\u9084\u6709\u5176\u4ed6\u4e09\u7a2e\u85e5\u7269\u6216\u5019\u9078\u85e5\u7269\u53ef\u4ee5\u6cbb\u7642\u6162\u6027\u4e59\u578b\u809d\u708e\uff0c\u5373\u5e02\u552e\u85e5\u54c1Pegasys\u00ae\uff0c\u4ee5\u53ca\u53e6\u5916\u5169\u6b3e\u65b0\u85e5\u7533\u8acb\u4e2d\u7684\u5019\u9078\u85e5\u7269\u3002<\/p>\n<p>\u6b4c\u79ae\u88fd\u85e5\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u9577\u517c\u9996\u5e2d\u57f7\u884c\u5b98Jinzi J. Wu\u535a\u58eb\u8aaa\uff1a\u201c\u6211\u5011\u5f88\u9ad8\u8208ASC22\u7372\u51c6\u5728\u6162\u6027\u4e59\u578b\u809d\u708e\u60a3\u8005\u4e2d\u9032\u884c\u81e8\u5e8a\u8a66\u9a57\u3002ASC22\u6709\u671b\u6210\u70ba\u6cbb\u7652\u6162\u6027\u4e59\u578b\u809d\u708e\u7684\u4e00\u6d41\u514d\u75ab\u7642\u6cd5\uff0c\u53ef\u4ee5\u4f5c\u70ba\u5404\u7a2e\u6cbb\u7642\u65b9\u6848\u7684\u57fa\u77f3\uff0c\u5305\u62ec\u8207\u6211\u5011\u5167\u90e8\u958b\u767c\u7684\u5019\u9078\u85e5\u7269\u4ee5\u53ca\u6f5b\u5728\u8207\u5176\u4ed6\u884c\u696d\u9818\u5c0e\u8005\u7684\u5019\u9078\u85e5\u7269\u806f\u5408\u4f7f\u7528\u3002 \u201d<\/p>\n<p>ASC22\uff0c\u4e5f\u7a31\u70baKN035\uff0c\u662f\u4e00\u7a2ePD-L1\u55ae\u7d50\u69cb\u57df\u6297\u9ad4Fc\u878d\u5408\u9ad4\uff0c\u5177\u6709\u76ae\u4e0b\u6ce8\u5c04\u548c\u5728\u5ba4\u6eab\u4e0b\u826f\u597d\u7a69\u5b9a\u6027\u7684\u512a\u9ede\u3002\u9019\u4e9b\u5c0d\u65bc\u63d0\u9ad8\u60a3\u8005\u7684\u4f9d\u5f9e\u6027\u548c\u751f\u6d3b\u8cea\u91cf\u4ee5\u53ca\u5e6b\u52a9\u8af8\u5982\u6162\u6027\u4e59\u578b\u809d\u708e\u7b49\u6162\u6027\u75be\u75c5\u7684\u9577\u671f\u7ba1\u7406\u5177\u6709\u91cd\u5927\u50f9\u503c\u3002<\/p>\n<p>\u6b4c\u79ae\u88fd\u85e5\u81f4\u529b\u65bc\u958b\u767c\u5275\u65b0\u85e5\u7269\u4e26\u5c07\u5176\u5546\u696d\u5316\uff0c\u91cd\u9ede\u662f\u91dd\u5c0d\u4e2d\u570b\u548c\u5168\u7403\u5c1a\u672a\u6eff\u8db3\u7684\u91ab\u7642\u9700\u6c42\u7684\u809d\u75c5\u3002\u5728\u64c1\u6709\u6df1\u539a\u5c08\u696d\u77e5\u8b58\u548c\u6210\u529f\u7d93\u9a57\u7684\u7ba1\u7406\u5718\u968a\u7684\u5e36\u9818\u4e0b\uff0c\u6b4c\u79ae\u88fd\u85e5\u5df2\u7d93\u767c\u5c55\u6210\u70ba\u4e00\u500b\u5b8c\u5168\u96c6\u6210\u7684\u5e73\u81fa\uff0c\u6db5\u84cb\u4e86\u5f9e\u767c\u73fe\u3001\u958b\u767c\u5230\u88fd\u9020\u548c\u5546\u696d\u5316\u7684\u6574\u500b\u50f9\u503c\u93c8\u3002<\/p>\n<p>\u82f1\u6587\u4f86\u6e90\uff1aBiospace<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ascletis Pharma Inc. (Ascletis, 1672.HK) announces today the approval for ASC22 to conduct clinical trials in chronic hepatitis B patients in China from China&#8217;s National Medical Products Administration. ASC22 is a first-in-class, subcutaneously administered PD-L1 antibody approved for such clinical trials in HBV patients on a global basis.<\/p>\n","protected":false},"author":9,"featured_media":314205,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[426],"tags":[809,927,563,564],"class_list":["post-314212","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-market-news-zh-hant","tag-809","tag-927","tag--zh-hant","tag-564","sectors-life-science-zh-hant","locations-us-zh-hant"],"acf":[],"_links":{"self":[{"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/posts\/314212","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/comments?post=314212"}],"version-history":[{"count":0,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/posts\/314212\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/media\/314205"}],"wp:attachment":[{"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/media?parent=314212"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/categories?post=314212"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/tags?post=314212"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}