{"id":318985,"date":"2020-02-21T19:09:18","date_gmt":"2020-02-22T03:09:18","guid":{"rendered":"https:\/\/nai500.com\/blog\/2020\/02\/crispr-intellia-%e5%9f%ba%e5%9b%a0%e7%bc%96%e8%be%91%e8%82%a1\/"},"modified":"2020-02-21T19:09:41","modified_gmt":"2020-02-22T03:09:41","slug":"crispr-intellia-%e5%9f%ba%e5%9b%a0%e7%b7%a8%e8%bc%af%e8%82%a1","status":"publish","type":"post","link":"https:\/\/nai500.com\/zh-hant\/blog\/2020\/02\/crispr-intellia-%e5%9f%ba%e5%9b%a0%e7%b7%a8%e8%bc%af%e8%82%a1\/","title":{"rendered":"CRISPR\u548cIntellia\uff0c\u9019\u5169\u96bb\u57fa\u56e0\u7de8\u8f2f\u80a1\u7684\u6295\u8cc7\u6f5c\u529b\u5c0d\u6bd4"},"content":{"rendered":"

\u5728\u751f\u7269\u79d1\u6280\u80a1\u7576\u4e2d\uff0c\u57fa\u56e0\u7de8\u8f2f\u80a1\u5c24\u5176\u53d7\u5e02\u5834\u95dc\u6ce8\uff0c\u5305\u62ec\u5176\u4e2d\u7684\u9f8d\u982d\u80a1CRISPR Therapeutics AG\uff08NASDAQ: CRSP\uff09<\/a>\u548cIntellia Therapeutics Inc\uff08NASDAQ: NTLA\uff09<\/a>\u3002\u9019\u5169\u5bb6\u516c\u53f8\u7684\u5728\u7814\u5019\u9078\u85e5\u524d\u666f\u53ef\u671f\uff0c\u5f88\u591a\u751a\u81f3\u6709\u53ef\u80fd\u6210\u7232\u91cd\u78c5\u85e5\uff0c\u540c\u6642\u85e5\u54c1\u958b\u767c\u8cc7\u91d1\u5145\u88d5\u3002\u5c0d\u4e8e\u8ffd\u6c42\u9ad8\u98a8\u96aa\u9ad8\u6536\u76ca\u7684\u6295\u8cc7\u8005\u4f86\u8aaa\uff0c\u9019\u5169\u96bb\u500b\u80a1\u7684\u6295\u8cc7\u6f5c\u529b\u90fd\u5f88\u7a81\u51fa\u3002<\/p>\n

\u4e0d\u904e\uff0c\u9019\u5169\u96bb\u57fa\u56e0\u7de8\u8f2f\u80a1\u4e5f\u5b58\u5728\u8457\u5dee\u5f02\uff0c\u672c\u6587\u5c07\u5f9e\u7523\u54c1\u7ba1\u7dab\u3001\u5546\u696d\u5408\u4f5c\u5925\u4f34\u95dc\u4fc2\u4ee5\u53ca\u76c8\u5229\u60c5\u51b5\u9032\u884c\u5206\u6790\u3002<\/p>\n

CRISPR\u7684\u7523\u54c1\u7ba1\u7dab<\/h2>\n

CRISPR\u7b97\u5f97\u4e0a\u662f\u57fa\u56e0\u7de8\u8f2f\u9818\u57df\u7684\u8001\u724c\u516c\u53f8\u4e86\uff0c\u516c\u53f8\u64c1\u67099\u6b3e\u5019\u9078\u85e5\uff0c\u4f46\u50c5\u67094\u6b3e\u8655\u4e8e\u81e8\u5e8a\u8a66\u9a57\u6216\u9130\u8fd1\u8a66\u9a57\u5553\u52d5\u968e\u6bb5\u3002<\/p>\n

\u5728\u9019\u4e9b\u5728\u7814\u85e5\u7269\u7576\u4e2d\uff0c\u6700\u6709\u524d\u666f\u7684\u662f\u942e\u72c0\u7d30\u80de\u75c5\uff08SCD\uff09\u548c\u8f38\u8840\u4f9d\u8cf4\u6027\u03b2-\u5730\u4e2d\u6d77\u8ca7\u8840\uff08TDT\uff09\u85e5\u7269CTX001\u3002\u7f8e\u570b\u5927\u7d04\u5f8c100,000\u4eba\u60a3\u6709\u942e\u72c0\u7d30\u80de\u75c5\uff0c\u52a0\u4e0a\u76ee\u524d\u9019\u5169\u7a2e\u907a\u50b3\u8840\u6db2\u75c5\u5c1a\u7121\u6cbb\u7642\u65b9\u6cd5\uff0c\u5982\u679c\u9019\u7a2e\u57fa\u56e0\u7de8\u8f2f\u85e5\u7269\u88ab\u8b49\u660e\u6709\u6548\uff0c\u5e02\u5834\u9700\u6c42\u5c07\u975e\u5e38\u9ad8\u3002<\/p>\n

CRISPR\u7684\u53e6\u59163\u6b3e\u81e8\u5e8a\u968e\u6bb5\u5019\u9078\u85e5\u5206\u5225\u7232\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u85e5\u7269CTX110\u3001CTX120\u548cCTX130\uff0c\u5177\u9ad4\u4f86\u8aaa\u5c31\u662f\u91dd\u5c0d\u665a\u671f\u764c\u75c7\u7684\u5d4c\u5408\u6297\u539f\u53d7\u9ad4T\u7d30\u80de\uff08CAR-T\uff09\u7642\u6cd5\u3002CAR-T\u7642\u6cd5\u901a\u904e\u4fee\u98fe\u60a3\u8005\u7684\u514d\u75ab\u7d30\u80de\uff08\u5c24\u5176\u662fT\u7d30\u80de\uff09\u4f86\u63d0\u9ad8\u5b83\u5011\u6bba\u6ec5\u764c\u7d30\u80de\u7684\u6548\u7387\uff0c\u5f9e\u4e8b\u5be6\u73fe\u6cbb\u7642\u76ee\u7684\u3002<\/p>\n

\u96d6\u7136\u6709\u6548\uff0c\u4f46CAR-T\u7d30\u80de\u7642\u6cd5\u975e\u5e38\u6602\u8cb4\uff0c\u958b\u652f\u901a\u5e38\u90fd\u5728\u6578\u5341\u842c\u751a\u81f3\u767e\u842c\u7f8e\u5143\u7d1a\u5225\u3002CRISPR\u81ea\u5bb6\u7684CAR-T\u85e5\u7269\u7684\u50f9\u683c\u6216\u6709\u53ef\u80fd\u4f4e\u4e8e\u5176\u4ed6\u540c\u985e\u85e5\u7269\u3002<\/p>\n

Intellia\u7684\u7523\u54c1\u7ba1\u7dab<\/h2>\n

Intellia\u64c1\u67097\u6b3e\u5019\u9078\u85e5\uff0c\u4f46\u5747\u8655\u4e8e\u7814\u7a76\u3001\u5019\u9078\u85e5\u9078\u64c7\u6216\u81e8\u5e8a\u524d\u6e2c\u8a66\u968e\u6bb5\u3002\u516c\u53f8\u7684\u942e\u72c0\u7d30\u80de\u75c5\u5019\u9078\u85e5\u5373\u5c07\u9032\u5165\u521d\u671f\u81e8\u5e8a\u8a66\u9a57\uff0c\u4f46\u9805\u76ee\u5c1a\u7121\u6b63\u5f0f\u540d\u7a31\uff0c\u5728\u516c\u53f8\u5b98\u7db2\u4e0a\u50c5\u793a\u5217\u7232\u201c\u942e\u72c0\u7d30\u80de\u75c5\u201d\u85e5\u7269\u3002<\/p>\n

\u6b64\u5916\uff0c\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u85e5\u7269NTLA-5001\u7684\u81e8\u5e8a\u524d\u9805\u76ee\u4e5f\u53d6\u5f97\u9032\u5c55\u3002\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u60a3\u8005\u76845\u5e74\u5b58\u6d3b\u7387\u53ea\u670927.4%\uff0c\u5360\u6240\u6709\u6210\u4eba\u767d\u8840\u75c5\u75c5\u4f8b\u6578\u768432%\u3002\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u5df2\u7d93\u6279\u51c6\u591a\u6b3eAML\u85e5\u7269\uff0c\u56e0\u6b64NTLA-5001\u82e5\u4e0a\u5e02\u5f8c\u9084\u5fc5\u9808\u8207\u5176\u4ed6\u85e5\u7269\u722d\u596a\u5e02\u5834\u4efd\u984d\u3002<\/p>\n

\u6700\u5f8c\uff0c\u8f49\u7532\u72c0\u817a\u7d20\u86cb\u767d\u6fb1\u7c89\u6a23\u8b8a\u6027\u6cbb\u7642\u85e5\u7269NTLA-2001\u76ee\u524d\u4ecd\u8655\u4e8e\u81e8\u5e8a\u524d\u958b\u767c\u968e\u6bb5\u3002\u9019\u7a2e\u75be\u75c5\u7684\u767c\u75c5\u7387\u53ea\u670910\u842c\u5206\u4e4b\u4e00\uff0c\u4f46\u76ee\u524d\u5c1a\u7121\u6cbb\u7642\u65b9\u6cd5\uff0c\u56e0\u6b64\u6f5c\u5728\u9700\u6c42\u9ad8\u3002<\/p>\n

\u8ca1\u52d9\u72c0\u51b5<\/h2>\n

\u7531\u4e8eCRISPR\u548cIntellia\u90fd\u662f\u521d\u671f\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u8003\u5bdf\u5e02\u92b7\u7387\uff08P\/S\uff09\u7b49\u50b3\u7d71\u8ca1\u52d9\u6307\u6a19\u610f\u7fa9\u4e0d\u5927\uff0c\u92b7\u552e\u984d\u4e5f\u4e0d\u662f\u6700\u91cd\u8981\u7684\u6307\u6a19\u3002<\/p>\n

\u4e0d\u904e\uff0cCRISPR\u7684\u8ca1\u52d9\u72c0\u51b5\u4f3c\u4e4e\u8981\u9060\u597d\u4e8eIntellia\u3002\u5728\u8a72\u516c\u53f8\u76842019\u5e74\u56db\u5b63\u5831\u7576\u4e2d\uff0cCRISPR\u516c\u544a\u5b63\u5ea6\u6536\u5165$7700\u842c\uff08\u4e3b\u8981\u4f86\u81ea\u798f\u6cf0\u88fd\u85e5Vertex Pharmaceuticals\u7684\u5408\u4f5c\u5354\u8b70\u800c\u975e\u7523\u54c1\u92b7\u552e\uff09\uff0c\u4f46\u8f03\u4e0a\u5e74\u540c\u671f\u7684$100,000\u4ecd\u662f\u5927\u5e45\u4e0a\u5347\u3002\u6b64\u5916\uff0c\u516c\u53f8\u73fe\u91d1\u4e5f\u5f9e\u4e0a\u5e74\u7684$4.566\u5104\u7ffb\u4e861\u500d\u591a\u81f3$9.438\u5104\u3002\u6700\u5f8c\uff0cCRISPR\u5be6\u73fe\u4e86\u521d\u671f\u751f\u7269\u79d1\u6280\u516c\u53f8\u5341\u5206\u7f55\u898b\u7684\u6210\u7e3e\uff1a\u5831\u544a\u76c8\u5229\u3002\u516c\u53f8\u5831\u544a\u6de8\u5229\u6f64$3050\u842c\uff0c\u800c2018\u5e74Q4\u9084\u662f\u8667\u640d$4760\u842c\u3002<\/p>\n

\u76f8\u6bd4\u4e4b\u4e0b\uff0cIntellia\u7684\u8ca1\u52d9\u72c0\u51b5\u5c31\u8981\u905c\u8272\u591a\u4e86\u3002\u8a72\u516c\u53f8\u516c\u544a\u5408\u4f5c\u6536\u5165$1060\u842c\uff0c\u8f03\u4e0a\u5e74\u540c\u671f\u7684$740\u842c\u589e\u957743%\uff0c\u4f46\u4ecd\u9060\u4f4e\u4e8eCRISPR\u3002\u6de8\u8667\u640d$2460\u842c\uff0c\u8ddf\u4e0a\u5e74\u57fa\u672c\u6301\u5e73\uff0c\u73fe\u91d1$2.958\u5104\u3002\u5728\u521d\u671f\u7684\u751f\u7269\u79d1\u6280\u80a1\u7576\u4e2d\uff0c\u9019\u5df2\u7d93\u662f\u76f8\u7576\u4e0d\u932f\u4e86\u3002\u6309\u7167\u7576\u524d\u7684\u958b\u652f\u6c34\u5e73\uff0cIntellia\u7684\u5eab\u5b58\u73fe\u91d1\u8db3\u591f\u652f\u6301\u516c\u53f8\u81f3\u5c113\u5e74\u7684\u958b\u92b7\uff0c\u56e0\u6b64\u6295\u8cc7\u8005\u7121\u9700\u64d4\u5fc3\u8cc7\u91d1\u554f\u984c\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

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