{"id":416811,"date":"2022-03-08T22:23:34","date_gmt":"2022-03-09T06:23:34","guid":{"rendered":"https:\/\/nai500.com\/blog\/2022\/03\/%e5%88%86%e6%9e%90%e5%b8%88%e4%bb%ac%e6%8e%a8%e8%8d%90%e8%bf%99%e4%ba%9b%e5%9f%ba%e5%9b%a0%e7%bc%96%e8%be%91%e8%82%a1%e7%a5%a8\/"},"modified":"2022-03-08T22:26:15","modified_gmt":"2022-03-09T06:26:15","slug":"%e5%88%86%e6%9e%90%e5%b8%ab%e5%80%91%e6%8e%a8%e8%96%a6%e9%80%99%e4%ba%9b%e5%9f%ba%e5%9b%a0%e7%b7%a8%e8%bc%af%e8%82%a1%e7%a5%a8","status":"publish","type":"post","link":"https:\/\/nai500.com\/zh-hant\/blog\/2022\/03\/%e5%88%86%e6%9e%90%e5%b8%ab%e5%80%91%e6%8e%a8%e8%96%a6%e9%80%99%e4%ba%9b%e5%9f%ba%e5%9b%a0%e7%b7%a8%e8%bc%af%e8%82%a1%e7%a5%a8\/","title":{"rendered":"\u5206\u6790\u5e2b\u5011\u63a8\u85a6\u9019\u4e9b\u57fa\u56e0\u7de8\u8f2f\u80a1\u7968"},"content":{"rendered":"

\u57fa\u56e0\u6cbb\u7642\u548c\u57fa\u56e0\u7de8\u8f2f\u662f\u73fe\u4ee3\u751f\u7269\u79d1\u6280\u7684\u6700\u524d\u6cbf\u3002\u57fa\u56e0\u6cbb\u7642\u662f\u901a\u904e\u5728\u7d30\u80de\u6c34\u5e73\u4e0a\u5f15\u5165\u907a\u50b3\u7269\u8cea\u4f86\u7cfe\u6b63\u907a\u50b3\u7570\u5e38\u3002\u57fa\u56e0\u7de8\u8f2f\u5c07\u79d1\u5b78\u63d0\u5347\u5230\u4e00\u500b\u65b0\u7684\u6c34\u5e73\uff0c\u5c0b\u6c42\u76f4\u63a5\u6539\u8b8a\u57fa\u56e0\u7d44\u672c\u8eab\u4f5c\u70ba\u4e00\u7a2e\u6cbb\u7642\u65b9\u6cd5\u3002\u5927\u591a\u6578\u57fa\u56e0\u7de8\u8f2f\u80a1\u7968\u5728\u6700\u8fd1\u5e7e\u500b\u6708\u53d7\u5230\u4e86\u91cd\u5275\uff0c\u4f46Fior Markets\u7684\u5206\u6790\u5e2b\u4ecd\u7136\u9810\u8a08\u5168\u7403\u57fa\u56e0\u7d44\u7de8\u8f2f\u5e02\u5834\u5c07\u5f9e2020\u5e74\u768442\u5104\u7f8e\u5143\u589e\u9577\u52302028\u5e74\u7684130\u5104\u7f8e\u5143\u3002\u6839\u64da\u7f8e\u570b\u9280\u884c\u7684\u6578\u64da\uff0c\u9019\u88e1\u6709\u5e7e\u96bb\u6700\u503c\u5f97\u8cfc\u8cb7\u7684\u57fa\u56e0\u7de8\u8f2f\u80a1\u7968\u3002<\/p>\n

CRISPR Therapeutics AG\uff08CRSP<\/a>\uff09<\/h2>\n

CRISPR Therapeutics\u662f\u4e00\u5bb6\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u4f7f\u7528\u57fa\u56e0\u7de8\u8f2f\u5de5\u5177CRISPR-Cas9\u6cbb\u7642\u8840\u7d05\u86cb\u767d\u75c5\uff0c\u5f9e\u800c\u6cbb\u7642\u8840\u6db2\u75be\u75c5\u548c\u764c\u75c7\u3002CRISPR \u5728\u81e8\u5e8a\u8a66\u9a57\u4e2d\u64c1\u6709\u4e09\u7a2e 100% \u64c1\u6709\u7684\u57fa\u56e0\u7de8\u8f2f\u7642\u6cd5\uff0c\u4e26\u6b63\u5728\u8207\u5408\u4f5c\u5925\u4f34 Vertex Pharmaceuticals Inc. (VRTX) \u548c ViaCyte Inc. \u5171\u540c\u958b\u767c\u53e6\u5916\u5169\u7a2e\u7642\u6cd5\u3002 CRSP\u80a1\u50f9\u5728\u904e\u53bb\u516d\u500b\u6708\u4e2d\u4e0b\u8dcc\u4e8650%\u4ee5\u4e0a\uff0c\u4f46\u5206\u6790\u5e2bGeoff Meacham\u8868\u793a\uff0c\u52302022\u5e74\u5e95CTX001\u53ef\u80fd\u63d0\u4ea4\u7684\u76e3\u7ba1\u6587\u4ef6\u7684\u66f4\u65b0\u53ef\u80fd\u6703\u63a8\u52d5CRISPR\u7684\u4f30\u503c\u91cd\u4f30\u3002\u7f8e\u570b\u9280\u884c\u5c0dCRSP\u80a1\u7968\u7684\u8a55\u7d1a\u70ba “\u8cb7\u5165”\uff0c\u76ee\u6a19\u50f9\u70ba150\u7f8e\u5143\uff0c3\u67084\u65e5\u7684\u6536\u76e4\u50f9\u70ba54.19\u7f8e\u5143\u3002<\/p>\n

Beam Therapeutics Inc. (BEAM<\/a>)<\/h2>\n

Beam Therapeutics\u5229\u7528CRISPR\u6280\u8853\u6539\u8b8a\u57fa\u56e0\u7d44\u4e2d\u7684\u55ae\u500b\u583f\u57fa\uff0c\u9019\u7a2e\u6280\u8853\u53ea\u7834\u58deDNA\u7684\u4e00\u689d\u93c8\uff0c\u4e26\u4e14\u53ef\u80fd\u6709\u66f4\u9ad8\u7684\u7d30\u80de\u5b58\u6d3b\u7387\u3002\u8a72\u516c\u53f8\u5c08\u6ce8\u65bc\u8840\u6db2\u75be\u75c5\u548c\u764c\u75c7\u9069\u61c9\u75c7\uff0c\u4f46\u4e5f\u5728\u7814\u7a76\u773c\u775b\u548c\u809d\u81df\u75be\u75c5\u7684\u6cbb\u7642\u3002\u5206\u6790\u5e2bGreg Harrison\u8aaa\uff0c\u8a72\u516c\u53f8\u7684BEAM-101\u7642\u6cd5\u6b63\u5728\u5411\u81e8\u5e8a\u7814\u7a76\u968e\u6bb5\u904e\u6e21\uff0c\u4e26\u53ef\u80fd\u57282022\u5e74\u4e0b\u534a\u5e74\u63d0\u4ea4BEAM-102\u548cBEAM-201\u7684\u65b0\u85e5\u7533\u8acb\u3002\u7f8e\u570b\u9280\u884c\u5c0dBEAM\u80a1\u7968\u7684\u8a55\u7d1a\u70ba”\u8cb7\u5165”\uff0c\u76ee\u6a19\u50f9\u70ba154\u7f8e\u5143\uff0c\u8a72\u80a13\u67084\u65e5\u6536\u4e8e64.38\u7f8e\u5143\u3002<\/p>\n

Apellis Pharmaceuticals Inc. (APLS<\/a>)<\/h2>\n

Apellis Pharmaceuticals\u662f\u4e00\u5bb6\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u5c08\u6ce8\u65bc\u91dd\u5c0d\u514d\u75ab\u7cfb\u7d71\u88dc\u9ad4\u9014\u5f91\u7684\u6cbb\u7642\uff0c\u589e\u5f37\u514d\u75ab\u7cfb\u7d71\u6e05\u9664\u53d7\u640d\u7d30\u80de\u7684\u80fd\u529b\u3002\u8a72\u516c\u53f8\u7684\u4e3b\u8981\u7522\u54c1\u662fpegcetacoplan\uff0c\u5df2\u7d93\u5728\u7f8e\u570b\u88ab\u6279\u51c6\u7528\u65bc\u6cbb\u7642\u9663\u767c\u6027\u591c\u9593\u8840\u7d05\u86cb\u767d\u5c3f\u75c7\u4e26\u8655\u65bc\u6cbb\u7642\u5730\u7406\u840e\u7e2e\u7684\u5f8c\u671f\u958b\u767c\u968e\u6bb5\u30022021\u5e746\u6708\uff0cApellis\u5ba3\u4f48\u8207Beam Therapeutics\u958b\u5c55\u65b0\u7684\u5408\u4f5c\uff0c\u5229\u7528\u57fa\u790e\u7de8\u8f2f\u6280\u8853\u7814\u7a76\u773c\u775b\u3001\u809d\u81df\u548c\u5927\u8166\u7684\u65b0\u7cbe\u51c6\u7642\u6cd5\u3002\u5206\u6790\u5e2bTazeen Ahmad\u8aaa\uff0c\u6295\u8cc7\u8005\u61c9\u671f\u5f85Apellis\u57282022\u5e74\u7b2c\u4e8c\u5b63\u5ea6\u63d0\u4ea4\u6cbb\u7642\u5730\u7406\u840e\u7e2e\u7684pegcetacoplan\u7684\u65b0\u85e5\u7533\u8acb\uff0c\u4e26\u57282022\u5e74\u5e95\u524d\u7372\u5f97\u6f5b\u5728\u7684\u76e3\u7ba1\u6279\u51c6\u3002\u7f8e\u570b\u9280\u884c\u5c0dAPLS\u7684\u8a55\u7d1a\u70ba “\u8cb7\u5165”\uff0c\u76ee\u6a19\u50f9\u70ba70\u7f8e\u5143\uff0c\u8a72\u516c\u53f83\u67084\u65e5\u6536\u76e4\u50f9\u70ba43.51\u7f8e\u5143\u3002<\/p>\n

Graphite Bio Inc. (GRPH<\/a>)<\/h2>\n

Graphite Bio\u662f\u4e00\u5bb6\u57fa\u56e0\u7de8\u8f2f\u6280\u8853\u516c\u53f8\uff0c\u4ee5GPH-101\u7814\u7a76\u6027\u57fa\u56e0\u7de8\u8f2f\u81ea\u9ad4\u9020\u8840\u5e79\u7d30\u80de\u5019\u9078\u7269\u5728\u8840\u7d05\u86cb\u767d\u75c5\u9818\u57df\u812b\u7a4e\u800c\u51fa\uff0c\u8a72\u5019\u9078\u7269\u6b63\u8655\u65bc\u6cbb\u7642\u942e\u72c0\u7d30\u80de\u75c5\u7684\u65e9\u671f\u81e8\u5e8a\u8a66\u9a57\u4e2d\u3002\u5176\u76ee\u7684\u662f\u7cfe\u6b63\u6f5b\u5728\u7684\u7a81\u8b8a\uff0c\u6e1b\u5c11\u942e\u72c0\u7d30\u80de\u7684\u7522\u751f\uff0c\u4e26\u4f7f\u7528\u4e00\u7a2e\u7a31\u70ba\u540c\u6e90\u5b9a\u5411\u4fee\u5fa9\u7684DNA\u4fee\u5fa9\u904e\u7a0b\u4f86\u6062\u5fa9\u6b63\u5e38\u7d30\u80de\u7684\u7522\u751f\u3002Meachim\u8aaa\uff0c\u6295\u8cc7\u8005\u53ef\u4ee5\u671f\u5f85\u57282022\u5e74\u5e95\u62162023\u5e74\u521d\u7372\u5f97GPH-101\u7684\u521d\u6b65\u81e8\u5e8a\u6578\u64da\u3002\u7f8e\u570b\u9280\u884c\u5c0dGRPH\u80a1\u7968\u7684\u8a55\u7d1a\u70ba”\u8cb7\u5165”\uff0c\u76ee\u6a19\u50f9\u70ba30\u7f8e\u5143\uff0c\u8a72\u80a13\u67084\u65e5\u6536\u4e8e8.17\u7f8e\u5143\u3002<\/p>\n

Caribou Biosciences Inc. (CRBU<\/a>)<\/h2>\n

Caribou Biosciences\u662f\u4e00\u5bb6\u81e8\u5e8a\u968e\u6bb5\u7684\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u958b\u767c\u7528\u65bc\u6cbb\u7642\u764c\u75c7\u7684\u57fa\u56e0\u7de8\u8f2f\u7684\u7570\u9ad4\u7d30\u80de\u7642\u6cd5\u3002\u8a72\u516c\u53f8\u65bc2021\u5e747\u6708\u5b8c\u6210\u9996\u6b21\u516c\u958b\u52df\u80a1\u3002Meachim\u8aaa\uff0cCaribou\u5c08\u6709\u7684chRDNA\u57fa\u56e0\u7de8\u8f2f\u65b9\u6cd5\u5728\u7642\u6548\u548c\u7279\u7570\u6027\u65b9\u9762\u53ef\u80fd\u6bd4\u50b3\u7d71\u65b9\u6cd5\u66f4\u6709\u512a\u52e2\u3002Caribou\u7684\u95dc\u93752022\u5e74\u50ac\u5316\u5291\u5305\u62ecCD-010\u7684\u521d\u59cb1\u671f\u6578\u64da\u4ee5\u53caCB-011\u7684\u65b0\u85e5\u7814\u7a76\u7533\u8acb\u3002\u7f8e\u570b\u9280\u884c\u5c0dCRBU\u80a1\u7968\u7684\u8a55\u7d1a\u70ba”\u8cb7\u5165”\uff0c\u76ee\u6a19\u50f9\u70ba33\u7f8e\u5143\uff0c3\u67084\u65e5\u7684\u6536\u76e4\u50f9\u70ba8.93\u7f8e\u5143\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

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