{"id":459853,"date":"2023-05-04T23:54:06","date_gmt":"2023-05-05T06:54:06","guid":{"rendered":"https:\/\/nai500.com\/blog\/2023\/05\/%e8%bf%99%e5%8f%aa%e6%88%90%e9%95%bf%e8%82%a1%e5%80%bc%e5%be%97%e5%9c%a8-5-%e6%9c%88%e8%bf%bd%e5%8a%a0%e6%8a%95%e8%b5%84\/"},"modified":"2023-05-05T01:14:59","modified_gmt":"2023-05-05T08:14:59","slug":"%e9%80%99%e5%8f%aa%e6%88%90%e9%95%b7%e8%82%a1%e5%80%bc%e5%be%97%e5%9c%a8-5-%e6%9c%88%e8%bf%bd%e5%8a%a0%e6%8a%95%e8%b3%87","status":"publish","type":"post","link":"https:\/\/nai500.com\/zh-hant\/blog\/2023\/05\/%e9%80%99%e5%8f%aa%e6%88%90%e9%95%b7%e8%82%a1%e5%80%bc%e5%be%97%e5%9c%a8-5-%e6%9c%88%e8%bf%bd%e5%8a%a0%e6%8a%95%e8%b3%87\/","title":{"rendered":"\u5e74\u521d\u4ee5\u4f86\u6301\u7e8c\u4e0a\u6f32\uff0c\u9019\u53ea\u6210\u9577\u80a1\u503c\u5f97\u57285\u6708\u8ffd\u52a0\u6295\u8cc7"},"content":{"rendered":"

\u9019\u53ea\u8dd1\u8d0f\u5e02\u5834\u7684\u751f\u7269\u79d1\u6280\u80a1\u4ecd\u6709\u66f4\u5927\u7684\u4e0a\u6f32\u7a7a\u9593\u3002\u6210\u9577\u80a1\u57282023\u5e74\u7684\u8868\u73fe\u51fa\u5947\u5730\u597d\u3002\u5118\u7ba1\u5229\u7387\u4e0d\u65b7\u4e0a\u5347\u3001\u53ef\u80fd\u51fa\u73fe\u8870\u9000\u548c\u5730\u5340\u9280\u884c\u696d\u5371\u6a5f\uff0c\u4f46\u4ee5\u6210\u9577\u70ba\u5c0e\u5411\u7684\u7d0d\u65af\u9054\u514b\u7d9c\u5408\u6307\u6578\u4eca\u5e74\u8fc4\u4eca\u5df2\u4e0a\u6f3214.8%\uff0c\u4ee4\u4eba\u5370\u8c61\u6df1\u523b\u3002<\/p>\n

\u4e8c\u5b63\u5ea6\u53ca\u4ee5\u5f8c\u54ea\u4e9b\u6210\u9577\u80a1\u5c07\u7e7c\u7e8c\u4e0a\u6f32\uff1f\u5275\u65b0\u5de8\u982dCRISPR Therapeutics(CRSP)<\/a>\u57282023\u5e74\u524d\u56db\u500b\u6708\u8dd1\u8d0f\u4e86\u5927\u76e4\u3002\u7531\u65bcCRISPR Therapeutics\u5728\u7814\u7522\u54c1\u7dda\u672a\u88ab\u6295\u8cc7\u8005\u5145\u5206\u8a8d\u8b58\u3001\u4ee5\u53ca\u4f5c\u70ba\u9802\u7d1a\u6536\u8cfc\u5019\u9078\u8005\u7684\u524d\u666f\uff0c\u8a72\u80a1\u7684\u4e0a\u6f32\u8da8\u52e2\u4f3c\u4e4e\u53ef\u80fd\u6703\u6301\u7e8c\u4e0b\u53bb\u3002<\/p>\n

\u65b0\u6642\u4ee3\u7684\u5275\u65b0<\/h2>\n

\u5341\u5e74\u524d\uff0c\u4f7f\u7528CRISPR\/Cas9\u5e73\u81fa\u6539\u8b8a\u4eba\u985e\u57fa\u56e0\u7d44DNA\u7684\u7279\u5b9a\u5e8f\u5217\u53ea\u4e0d\u904e\u662f\u4e00\u500b\u6709\u8da3\u7684\u60f3\u6cd5\u3002\u4e0a\u500b\u6708\uff0cCRISPR\u548c\u5408\u4f5c\u5925\u4f34Vertex Pharmaceuticals(VRTX)<\/a>\u63d0\u4ea4\u4e86\u6cbb\u7642\u7f55\u898b\u8840\u6db2\u75c5\u942e\u72c0\u7d30\u80de\u75c5(SCD)\u548c\u8f38\u8840\u4f9d\u8cf4\u6027\u03b2\u5730\u4e2d\u6d77\u8ca7\u8840(TDT)\u7684exa-cel\u7684\u751f\u7269\u88fd\u54c1\u8a31\u53ef\u7533\u8acb\u3002<\/p>\n

Exa-cel\u662f\u4e00\u7a2e\u81ea\u9ad4\u3001\u9ad4\u5916CRISPR\/Cas9\u57fa\u56e0\u7de8\u8f2f\u7642\u6cd5\uff0c\u53ef\u4f7f\u60a3\u8005\u7684\u9020\u8840\u5e79\u7d30\u80de\u5728\u7d05\u7d30\u80de\u4e2d\u7522\u751f\u9ad8\u6c34\u5e73\u7684\u80ce\u5152\u8840\u7d05\u86cb\u767d\u3002\u9019\u4e00\u5c16\u7aef\u6280\u8853\u5728\u5927\u7d0410\u5e74\u7684\u6642\u9593\u88e1\u5f9e\u4e00\u500b\u6709\u8da3\u7684\u6982\u5ff5\u4e00\u8def\u767c\u5c55\u6210\u70ba\u6539\u8b8a\u904a\u6232\u898f\u5247\u7684\u7642\u6cd5\uff0c\u9019\u4e00\u4e8b\u5be6\u8b49\u660e\u77adCRISPR\u81e8\u5e8a\u5718\u968a\u548c\u9ad8\u5c64\u7ba1\u7406\u4eba\u54e1\u7684\u7368\u7279\u624d\u80fd\u3002<\/p>\n

\u7136\u800c\uff0c\u5e02\u5834\u4f3c\u4e4e\u4e26\u672a\u5b8c\u5168\u7406\u89e3\u9019\u4e00\u4eba\u985e\u91ab\u5b78\u9818\u57df\u7684\u91cc\u7a0b\u7891\u5f0f\u9032\u6b65\u3002\u9996\u5148\uff0cCRISPR\u548cVertex\u5c31exa-cel\u7c3d\u8a02\u4e86\u6536\u5165\u5206\u6210\u5354\u8b70\uff0c\u56e0\u6b64CRISPR\u4e0d\u6703\u4eab\u53d7exa-cel\u5c0dSCD\u548cTDT\u7684\u5546\u696d\u5316\uff08\u5047\u8a2d\u7372\u5f97\u6279\u51c6\uff09\u7684\u5168\u90e8\u6536\u76ca\u3002\u63a5\u4e0b\u4f86\uff0cexa-cel\u5c07\u5728\u9019\u4e9b\u9069\u61c9\u75c7\u4e0a\u8207BluebirdBio\u7684\u57fa\u56e0\u6cbb\u7642\u7522\u54c1\u7af6\u722d\uff0c\u9019\u5e36\u4f86\u4e86\u984d\u5916\u7684\u4e0d\u78ba\u5b9a\u6027\u3002\u6700\u5f8c\uff0c\u5f9e\u60a3\u8005\u548c\u81e8\u5e8a\u91ab\u751f\u7684\u5f8c\u52e4\u89d2\u5ea6\u4f86\u770b\uff0c\u57fa\u56e0\u7de8\u8f2f\u7522\u54c1\u672c\u8eab\u5c31\u5f88\u9ebb\u7169\u3002<\/p>\n

\u6295\u8cc7\u539f\u56e0\uff1f<\/h2>\n

\u90a3\u9ebc\uff0c\u70ba\u4ec0\u9ebcCRISPR\u7684\u80a1\u7968\u73fe\u5728\u503c\u5f97\u8cb7\u5165\uff1f\u9019\u4e00\u5207\u90fd\u6b78\u7d50\u70ba\u9019\u6a23\u4e00\u500b\u4e8b\u5be6\uff0c\u5373\u8a72\u516c\u53f8\u7684\u57fa\u56e0\u7de8\u8f2f\u5e73\u81fa\u5373\u5c07\u901a\u904eexa-cel\u7684\u6f5b\u5728\u6279\u51c6\u6210\u70ba\u4e00\u500b\u7d93\u904e\u9a57\u8b49\u7684\u5e73\u81fa\u3002\u6279\u51c6\u5c07\u6703\u6539\u8b8a\u9802\u7d1a\u57fa\u91d1\u7d93\u7406\u5c0d\u516c\u53f8\u5176\u4ed6\u9ad8\u50f9\u503c\u7ba1\u9053\u5019\u9078\u7522\u54c1\u7684\u98a8\u96aa\u56de\u5831\u7387\u7684\u770b\u6cd5\u3002<\/p>\n

\u53e6\u4e00\u500b\u9700\u8981\u8003\u616e\u7684\u91cd\u8981\u554f\u984c\u662f\uff0c\u5728\u904e\u53bb20\u500b\u6708\u751f\u7269\u79d1\u6280\u4f30\u503c\u6b77\u7d93\u4f4e\u8ff7\u4e4b\u5f8c\uff0c\u5927\u578b\u88fd\u85e5\u516c\u53f8\u4e00\u76f4\u5728\u5c0b\u627e\u6536\u8cfc\u76ee\u6a19\u3002CRISPR\u6709\u5229\u7684\u98a8\u96aa\u56de\u5831\u6bd4\u3001\u7368\u7279\u7684\u6cbb\u7642\u5e73\u81fa\u548c\u4e00\u6d41\u7684\u4eba\u624d\u4f7fCRISPR\u6210\u70ba\u9019\u7a2e\u74b0\u5883\u4e2d\u6975\u5177\u5438\u5f15\u529b\u7684\u6536\u8cfc\u76ee\u6a19\u3002<\/p>\n

\u7e3d\u800c\u8a00\u4e4b\uff0c\u7cbe\u660e\u7684\u6295\u8cc7\u8005\u61c9\u8a72\u6beb\u4e0d\u7336\u8c6b\u5730\u5229\u7528\u5e02\u5834\u5c0dCRISPR\u6beb\u7121\u6839\u64da\u7684\u60b2\u89c0\u60c5\u7dd2\u3002\u7562\u7adf\uff0c\u9019\u53ea\u88ab\u4f4e\u4f30\u7684\u751f\u7269\u79d1\u6280\u6210\u9577\u80a1\u5177\u5099\u6210\u70ba\u9577\u671f\u8d0f\u5bb6\u7684\u6240\u6709\u5fc5\u8981\u56e0\u7d20\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u9019\u53ea\u8dd1\u8d0f\u5e02\u5834\u7684\u751f\u7269\u79d1\u6280\u80a1\u4ecd\u6709\u66f4\u5927\u7684\u4e0a\u6f32\u7a7a\u9593\u3002\u6210\u9577\u80a1\u57282023\u5e74\u7684\u8868\u73fe\u51fa\u5947\u5730\u597d\u3002\u5118\u7ba1\u5229\u7387\u4e0d\u65b7\u4e0a\u5347\u3001\u53ef\u80fd\u51fa\u73fe\u8870\u9000\u548c […]<\/p>\n","protected":false},"author":9,"featured_media":459850,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[426],"tags":[927,563,564],"class_list":["post-459853","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-market-news-zh-hant","tag-927","tag--zh-hant","tag-564","sectors-life-science-zh-hant","locations-us-zh-hant","exchange-nasdaq-zh-hant","exchange-nyse-zh-hant"],"acf":[],"_links":{"self":[{"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/posts\/459853","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/comments?post=459853"}],"version-history":[{"count":0,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/posts\/459853\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/media\/459850"}],"wp:attachment":[{"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/media?parent=459853"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/categories?post=459853"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/tags?post=459853"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}