{"id":556119,"date":"2024-11-02T00:56:06","date_gmt":"2024-11-02T07:56:06","guid":{"rendered":"https:\/\/nai500.com\/blog\/2024\/11\/crispr-%e5%9f%ba%e5%9b%a0%e7%bc%96%e8%be%91%e5%b0%86%e8%bf%8e%e6%9d%a5%e9%87%8d%e5%a4%a7%e7%aa%81%e7%a0%b4%e5%93%aa%e4%ba%9b%e8%82%a1%e7%a5%a8%e5%80%bc%e5%be%97%e5%85%b3%e6%b3%a8\/"},"modified":"2024-11-02T00:56:45","modified_gmt":"2024-11-02T07:56:45","slug":"crispr-%e5%9f%ba%e5%9b%a0%e7%b7%a8%e8%bc%af%e5%b0%87%e8%bf%8e%e4%be%86%e9%87%8d%e5%a4%a7%e7%aa%81%e7%a0%b4%e5%93%aa%e4%ba%9b%e8%82%a1%e7%a5%a8%e5%80%bc%e5%be%97%e9%97%9c%e6%b3%a8","status":"publish","type":"post","link":"https:\/\/nai500.com\/zh-hant\/blog\/2024\/11\/crispr-%e5%9f%ba%e5%9b%a0%e7%b7%a8%e8%bc%af%e5%b0%87%e8%bf%8e%e4%be%86%e9%87%8d%e5%a4%a7%e7%aa%81%e7%a0%b4%e5%93%aa%e4%ba%9b%e8%82%a1%e7%a5%a8%e5%80%bc%e5%be%97%e9%97%9c%e6%b3%a8\/","title":{"rendered":"CRISPR\u57fa\u56e0\u7de8\u8f2f\u5c07\u8fce\u4f86\u91cd\u5927\u7a81\u7834\uff0c\u54ea\u4e9b\u80a1\u7968\u503c\u5f97\u95dc\u6ce8\uff1f"},"content":{"rendered":"

CRISPR\u57fa\u56e0\u7d44\u7de8\u8f2f\u591a\u5e74\u4f86\u4e00\u76f4\u88ab\u5927\u8086\u5ba3\u50b3\u3002\u4f46CRISPR\u6280\u8853\u7684\u524d\u666f\u5c1a\u672a\u5be6\u73fe\u3002\u4e0d\u904e\uff0c\u9019\u7a2e\u60c5\u6cc1\u53ef\u80fd\u6703\u5728\u672a\u4f86\u5e7e\u5e74\u767c\u751f\u8b8a\u5316\u3002\u57fa\u56e0\u7d44\u5b78\u7684\u91cd\u5927\u7a81\u7834\u4ee5\u53ca\u67d0\u4e9b\u80a1\u7968\u7684\u6f5b\u5728\u7206\u70b8\u5f0f\u589e\u9577\u53ef\u80fd\u5373\u5c07\u5230\u4f86\u3002<\/p>\n

\u591a\u5bb6\u516c\u53f8\u6b63\u5728\u4f7f\u7528CRISPR\u7de8\u8f2f\u4eba\u985e\u57fa\u56e0\u7d44\uff0c\u8a66\u5716\u6cbb\u7642\uff08\u751a\u81f3\u6cbb\u7652\uff09\u907a\u50b3\u75be\u75c5\u3002\u4f46CRISPR\u7684\u7528\u9014\u4e0d\u50c5\u9650\u65bc\u907a\u50b3\u75be\u75c5\u3002\u591a\u5bb6\u57fa\u56e0\u7de8\u8f2f\u516c\u53f8\u9084\u91dd\u5c0d\u5404\u7a2e\u985e\u578b\u7684\u764c\u75c7\u3002\u7279\u5225\u662f\uff0cCRISPR\u88ab\u7528\u65bc\u958b\u767c\u5d4c\u5408\u6297\u539f\u53d7\u9ad4(CAR)T\u7d30\u80de\u7642\u6cd5\uff0c\u5176\u4e2d\u514d\u75ab\u7d30\u80de\u7d93\u904e\u57fa\u56e0\u5de5\u7a0b\u6539\u9020\u4ee5\u653b\u64ca\u7279\u5b9a\u816b\u7624\u3002\u4e26\u975e\u6bcf\u500b\u6295\u8cc7\u8005\u90fd\u60f3\u8cfc\u8cb7CRISPR\u57fa\u56e0\u7de8\u8f2f\u80a1\u7968\u3002\u9019\u4e9b\u80a1\u7968\u5f80\u5f80\u98a8\u96aa\u9ad8\u4e14\u6ce2\u52d5\u6027\u5927\u3002\u7136\u800c\uff0c\u5c0d\u65bc\u4e0d\u898f\u907f\u98a8\u96aa\u7684\u7a4d\u6975\u6295\u8cc7\u8005\u4f86\u8aaa\uff0c\u4ee5\u4e0b\u662f\u5e7e\u96bb\u503c\u5f97\u8cfc\u8cb7\u7684CRISPR\u57fa\u56e0\u7de8\u8f2f\u80a1\u7968\u3002<\/p>\n

Beam Therapeutics<\/h2>\n

Beam Therapeutics<\/a>\u7684\u583f\u57fa\u7de8\u8f2f\u65b9\u6cd5\u5177\u6709\u591a\u9805\u512a\u52e2\u3002\u9019\u4e9b\u512a\u52e2\u5305\u62ec\u80fd\u5920\u7cbe\u78ba\u7784\u6e96\u7279\u5b9a\u57fa\u56e0\u5e8f\u5217\u4e26\u7de8\u8f2f\u57fa\u56e0\uff0c\u800c\u4e0d\u6703\u7522\u751f\u610f\u5916\u5f8c\u679c\uff0c\u4f8b\u5982\u4ee5\u6bd4\u8a08\u5283\u66f4\u5927\u7684\u898f\u6a21\u91cd\u65b0\u6392\u5217\u57fa\u56e0\u7d44\u3002\u8a72\u516c\u53f8\u6b63\u5728\u8a55\u4f30\u56db\u7a2e\u8655\u65bc1\/2\u671f\u81e8\u5e8a\u8a66\u9a57\u968e\u6bb5\u7684\u5019\u9078\u85e5\u7269\uff0c\u9019\u4e9b\u85e5\u7269\u91dd\u5c0d\u7684\u662f\u7f55\u898b\u7684\u907a\u50b3\u75be\u75c5\u942e\u72c0\u7d30\u80de\u75c5\u3001\u03b1-1\u6297\u80f0\u86cb\u767d\u9176\u7f3a\u4e4f\u75c7(AATD)\u548c\u7cd6\u539f\u7d2f\u7a4d\u75c51a(GSD1a)\u4ee5\u53caT\u7d30\u80de\u767d\u8840\u75c5\/\u6dcb\u5df4\u7624\u3002<\/p>\n

CRISPR Therapeutics<\/h2>\n

CRISPR Therapeutics<\/a>\u662f\u552f\u4e00\u4e00\u5bb6\u5c08\u6ce8\u65bcCRISPR\u7684\u751f\u7269\u79d1\u6280\u80a1\u7968\u3002\u8a72\u516c\u53f8\u53ca\u5176\u5408\u4f5c\u5925\u4f34Vertex Pharmaceuticals (VRTX)<\/a>\u65bc2023\u5e7412\u6708\u7372\u5f97\u4e86\u7f8e\u570b\u76e3\u7ba1\u6a5f\u69cb\u5c0dCasgevy\u7684\u6279\u51c6\uff0c\u7528\u65bc\u6cbb\u7642\u942e\u72c0\u7d30\u80de\u75c5\uff0c\u4e26\u65bc2024\u5e741\u6708\u7372\u5f97\u4e86\u6cbb\u7642\u8f38\u8840\u4f9d\u8cf4\u6027\u03b2-\u5730\u4e2d\u6d77\u8ca7\u8840\u7684\u6279\u51c6\u3002<\/p>\n

\u5118\u7ba1\u6240\u6709CRISPR\u80a1\u7968\u90fd\u6709\u98a8\u96aa\uff0c\u4f46CRISPR Therapeutics\u7684\u98a8\u96aa\u53ef\u4ee5\u8aaa\u6bd4\u5927\u591a\u6578\u80a1\u7968\u90fd\u8981\u5c0f\u3002\u8a72\u516c\u53f8\u64c1\u6709\u5f37\u5927\u7684\u73fe\u91d1\u72c0\u6cc1\uff0c\u9019\u4e3b\u8981\u6b78\u529f\u65bc\u8207Vertex\u7684\u5408\u4f5c\uff0c\u4e26\u4e14\u5e02\u5834\u4e0a\u6709\u4e00\u6b3e\u7372\u6279\u7522\u54c1\u3002<\/p>\n

Editas Medicine<\/h2>\n

Editas Medicine<\/a>\u5728\u4f7f\u7528CRISPR\u6cbb\u7642\u7f55\u898b\u907a\u50b3\u6027\u773c\u75c5\u65b9\u9762\u8655\u65bc\u9818\u5148\u5730\u4f4d\u3002\u7136\u800c\uff0c\u5728\u81e8\u5e8a\u8a66\u9a57\u7d50\u679c\u4ee4\u4eba\u5931\u671b\u5f8c\uff0c\u8a72\u516c\u53f8\u6700\u7d42\u653e\u68c4\u4e86\u9019\u4e9b\u52aa\u529b\u3002<\/p>\n

\u4f46Editas\u4ecd\u7136\u5c0d\u4e3b\u8981\u5019\u9078\u85e5\u7269reni-cel\uff08\u4ee5\u524d\u7a31\u70baEDIT-301\uff09\u5bc4\u4e88\u539a\u671b\u3002\u8a72\u516c\u53f8\u6b63\u5728\u5f8c\u671f\u7814\u7a76\u4e2d\u8a55\u4f30\u8a72\u5be6\u9a57\u7642\u6cd5\u4f5c\u70ba\u942e\u72c0\u7d30\u80de\u75c5\u7684\u6cbb\u7642\u65b9\u6cd5\uff0c\u4e26\u5728\u9032\u884c\u91dd\u5c0d\u03b2-\u5730\u4e2d\u6d77\u8ca7\u8840\u7684\u65e9\u671f\u7814\u7a76\u3002<\/p>\n

\u8a72\u516c\u53f8\u8a8d\u70ba\uff0creni-cel\u53ef\u80fd\u662f\u6cbb\u7642\u942e\u72c0\u7d30\u80de\u75c5\u548c\u03b2-\u5730\u4e2d\u6d77\u8ca7\u8840\u7684\u201c\u4e00\u6d41\u201d\u7642\u6cd5\u3002\u5230\u76ee\u524d\u70ba\u6b62\uff0c\u81e8\u5e8a\u8a66\u9a57\u7684\u7d50\u679c\u4ee4\u4eba\u9f13\u821e\u3002Editas\u9084\u5728\u7e7c\u7e8c\u958b\u767c\u9ad4\u5167\u7642\u6cd5\u3002\u4e0d\u904e\uff0c\u5230\u76ee\u524d\u70ba\u6b62\uff0c\u8a72\u516c\u53f8\u9084\u6c92\u6709\u5c07\u4efb\u4f55\u5176\u4ed6\u9ad4\u5167\u9805\u76ee\u63a8\u9032\u5230\u81e8\u5e8a\u8a66\u9a57\u968e\u6bb5\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

CRISPR\u57fa\u56e0\u7d44\u7de8\u8f2f\u591a\u5e74\u4f86\u4e00\u76f4\u88ab\u5927\u8086\u5ba3\u50b3\u3002\u4f46CRISPR\u6280\u8853\u7684\u524d\u666f\u5c1a\u672a\u5be6\u73fe\u3002\u4e0d\u904e\uff0c\u9019\u7a2e\u60c5\u6cc1\u53ef\u80fd\u6703\u5728\u672a\u4f86\u5e7e\u5e74\u767c […]<\/p>\n","protected":false},"author":9,"featured_media":556117,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[426],"tags":[809,927,644,564],"class_list":["post-556119","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-market-news-zh-hant","tag-809","tag-927","tag-644","tag-564","sectors-life-science-zh-hant","locations-us-zh-hant","exchange-nasdaq-zh-hant","exchange-nyse-zh-hant"],"acf":[],"_links":{"self":[{"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/posts\/556119","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/comments?post=556119"}],"version-history":[{"count":3,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/posts\/556119\/revisions"}],"predecessor-version":[{"id":556122,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/posts\/556119\/revisions\/556122"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/media\/556117"}],"wp:attachment":[{"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/media?parent=556119"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/categories?post=556119"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/tags?post=556119"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}