{"id":569427,"date":"2025-03-20T23:16:45","date_gmt":"2025-03-21T06:16:45","guid":{"rendered":"https:\/\/nai500.com\/blog\/2025\/03\/%e7%be%8e%e8%82%a1%e5%9f%ba%e5%9b%a0%e7%bc%96%e8%be%91%e8%82%a1%e7%a5%a8%e6%8a%95%e8%b5%84%e6%8c%87%e5%8d%97%e5%8f%8a%e7%b2%be%e9%80%89%e4%b8%aa%e8%82%a1\/"},"modified":"2025-03-20T23:17:27","modified_gmt":"2025-03-21T06:17:27","slug":"%e7%be%8e%e8%82%a1%e5%9f%ba%e5%9b%a0%e7%b7%a8%e8%bc%af%e8%82%a1%e7%a5%a8%e6%8a%95%e8%b3%87%e6%8c%87%e5%8d%97%e5%8f%8a%e7%b2%be%e9%81%b8%e5%80%8b%e8%82%a1","status":"publish","type":"post","link":"https:\/\/nai500.com\/zh-hant\/blog\/2025\/03\/%e7%be%8e%e8%82%a1%e5%9f%ba%e5%9b%a0%e7%b7%a8%e8%bc%af%e8%82%a1%e7%a5%a8%e6%8a%95%e8%b3%87%e6%8c%87%e5%8d%97%e5%8f%8a%e7%b2%be%e9%81%b8%e5%80%8b%e8%82%a1\/","title":{"rendered":"\u7f8e\u80a1\u57fa\u56e0\u7de8\u8f2f\u80a1\u7968\u6295\u8cc7\u6307\u5357\u53ca\u7cbe\u9078\u500b\u80a1"},"content":{"rendered":"<p>2020\u5e74\uff0c\u7f8e\u570b\u751f\u7269\u5316\u5b78\u5bb6Jennifer Doudna\u8207\u6cd5\u570b\u5fae\u751f\u7269\u5b78\u5bb6Emmanuelle Charpentier\u56e0\u767c\u73feCRISPR\u57fa\u56e0\u7de8\u8f2f\u6280\u8853\u69ae\u7372\u8afe\u8c9d\u723e\u5316\u5b78\u734e\u3002\u745e\u5178\u7687\u5bb6\u79d1\u5b78\u9662\u8a55\u50f9\u9019\u4e00\u767c\u73fe\u201c\u6539\u5beb\u4e86\u751f\u547d\u7684\u5bc6\u78bc\u201d\uff0c\u70ba\u91ab\u5b78\u9818\u57df\u958b\u555f\u9769\u547d\u6027\u53ef\u80fd\u3002\u5728\u8cc7\u672c\u5e02\u5834\u4e0a\uff0c\u57fa\u56e0\u7de8\u8f2f\u80a1\u7968\u4e5f\u7d1b\u7d1b\u6e67\u73fe\uff0c\u70ba\u6295\u8cc7\u8005\u63d0\u4f9b\u4e86\u65b0\u7684\u6295\u8cc7\u6a5f\u6703\u3002<\/p>\n<p>\u57fa\u56e0\u7de8\u8f2f\u5e02\u5834\u9810\u8a08\u52302032\u5e74\u5c07\u9054308\u5104\u7f8e\u5143\uff0c\u6838\u5fc3\u9a45\u52d5\u529b\u70baCRISPR\u6280\u8853\u5c0d\u907a\u50b3\u75be\u75c5\u7684\u6cbb\u7642\u6f5b\u529b\u3002\u8a72\u6280\u8853\u901a\u904e\u7cbe\u51c6\u4fee\u6539DNA\uff0c\u6709\u671b\u5be6\u73fe\u201c\u4e00\u52de\u6c38\u9038\u201d\u7684\u6cbb\u7652\u65b9\u6848\uff0c\u8986\u84cb\u942e\u72c0\u7d30\u80de\u8ca7\u8840\u3001\u7f55\u898b\u4ee3\u8b1d\u75c5\u3001\u764c\u75c7\u7b49\u9818\u57df\u3002\u5982\u300a\u5bc6\u78bc\u7834\u8b6f\u8005\u300b\u4f5c\u8005Walter Isaacson\u6240\u8a00\uff0cCRISPR\u5c07\u201c\u91cd\u5851\u4eba\u985e\u672a\u4f86\u201d\u3002<\/p>\n<h2>\u6295\u8cc7\u7b56\u7565\u8207\u98a8\u96aa\u63d0\u793a<\/h2>\n<p><strong>\u7b56\u7565\u5efa\u8b70<\/strong>\uff1a<\/p>\n<ul>\n<li><strong>\u7d44\u5408\u5206\u6563\uff1a<\/strong>\u57fa\u56e0\u7de8\u8f2f\u884c\u696d\u6ce2\u52d5\u6027\u9ad8\uff0c\u5efa\u8b70\u914d\u7f6e\u591a\u96bb\u80a1\u7968\uff08\u5982Intellia+CRISPR+Beam\uff09\u4ee5\u5e73\u8861\u98a8\u96aa\u3002<\/li>\n<li><strong>\u9577\u671f\u6301\u6709\uff1a<\/strong>\u85e5\u7269\u7814\u767c\u9031\u671f\u9577\uff085-10\u5e74\uff09\uff0c\u9700\u8010\u5fc3\u7b49\u5f85\u7ba1\u7dda\u63a8\u9032\u8207\u5546\u696d\u5316\u653e\u91cf\u3002<\/li>\n<li><strong>\u95dc\u6ce8\u91cc\u7a0b\u7891\uff1a<\/strong>\u81e8\u5e8a\u8a66\u9a57\u7d50\u679c\u3001FDA\u5be9\u6279\u3001\u5408\u4f5c\u5925\u4f34\u52d5\u614b\u70ba\u80a1\u50f9\u95dc\u9375\u50ac\u5316\u5291\u3002<\/li>\n<\/ul>\n<p><strong>\u98a8\u96aa\u8b66\u793a<\/strong>\uff1a<\/p>\n<ul>\n<li><strong>\u6280\u8853\u4e0d\u78ba\u5b9a\u6027<\/strong>\uff1a\u57fa\u56e0\u7de8\u8f2f\u53ef\u80fd\u5f15\u767c\u812b\u9776\u6548\u61c9\uff0c\u9577\u671f\u5b89\u5168\u6027\u9700\u9a57\u8b49\u3002<\/li>\n<li><strong>\u653f\u7b56\u76e3\u7ba1<\/strong>\uff1a\u502b\u7406\u722d\u8b70\u8207\u5404\u570b\u6cd5\u898f\u53ef\u80fd\u5f71\u97ff\u7814\u767c\u9032\u5ea6\u3002<\/li>\n<li><strong>\u5e02\u5834\u6ce2\u52d5<\/strong>\uff1a\u4f01\u696d\u4f9d\u8cf4\u878d\u8cc7\uff0c\u80a1\u50f9\u6613\u53d7\u81e8\u5e8a\u6578\u64da\u6216\u884c\u696d\u60c5\u7dd2\u5f71\u97ff\u5287\u70c8\u6ce2\u52d5\u3002<\/li>\n<\/ul>\n<h2>\u6838\u5fc3\u4f01\u696d\u5206\u6790\u8207\u6295\u8cc7\u6a19\u7684<\/h2>\n<p>\u4ee5\u4e0b\u4e09\u96bb\u57fa\u56e0\u7de8\u8f2f\u80a1\u7968\u503c\u5f97\u95dc\u6ce8\uff08\u6578\u64da\u622a\u81f32025\u5e743\u670820\u65e5\uff09\uff1a<\/p>\n<table>\n<thead>\n<tr>\n<td><strong>\u516c\u53f8\u540d\u7a31<\/strong><\/td>\n<td><strong>\u80a1\u7968\u4ee3\u78bc<\/strong><\/td>\n<td><strong>\u5e02\u503c<\/strong><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Intellia Therapeutics<\/td>\n<td><a href=\"https:\/\/nai500.com\/zh-hans\/%e8%82%a1%e7%a5%a8%e6%9f%a5%e8%af%a2\/?qm_symbol=NTLA\">NASDAQ:NTLA<\/a><\/td>\n<td>9.63\u5104\u7f8e\u5143<\/td>\n<\/tr>\n<tr>\n<td>CRISPR Therapeutics<\/td>\n<td>NASDAQ:CRSP<\/td>\n<td>\u6578\u64da\u66ab\u7f3a<\/td>\n<\/tr>\n<tr>\n<td>Beam Therapeutics<\/td>\n<td>NASDAQ:BEAM<\/td>\n<td>20\u5104\u7f8e\u5143<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3>1. Intellia Therapeutics<\/h3>\n<ul>\n<li><strong>\u5275\u59cb\u4eba<\/strong>\uff1a\u8afe\u8c9d\u723e\u734e\u5f97\u4e3bJennifer Doudna\u4e8e2014\u5e74\u806f\u5408\u5275\u7acb\u3002<\/li>\n<li><strong>\u6280\u8853\u4eae\u9ede<\/strong>\uff1a\u5c08\u6ce8<strong>\u9ad4\u5167\u57fa\u56e0\u7de8\u8f2f<\/strong>\uff08in vivo\uff09\uff0c\u8207\u518d\u751f\u5143\uff08Regeneron\uff09\u5408\u4f5c\u958b\u767cCRISPR-Cas9\u7642\u6cd5\u3002\n<ul>\n<li><strong>nexiguran ziclumeran<\/strong><strong>\uff08\u524d\u7a31<\/strong><strong>NTLA-2001<\/strong><strong>\uff09<\/strong>\uff1a\u91dd\u5c0d\u8f49\u7532\u72c0\u817a\u7d20\u86cb\u767d\u6fb1\u7c89\u6a23\u8b8a\u6027\uff08ATTR\uff09\u7684\u5f8c\u671f\u81e8\u5e8a\u5019\u9078\u85e5\u7269\u3002<\/li>\n<li><strong>NTLA-2002<\/strong>\uff1a\u8a08\u52832026\u5e74\u5411\u7f8e\u570bFDA\u7533\u8acb\u6279\u51c6\u6cbb\u7642\u907a\u50b3\u6027\u8840\u7ba1\u6027\u6c34\u816b\uff0c2027\u5e74\u4e0a\u5e02\u3002<\/li>\n<li><strong>B<\/strong><strong>\u578b\u8840\u53cb\u75c5\u7642\u6cd5<\/strong>\uff1a\u518d\u751f\u5143\u4e3b\u5c0e\u7684II\u671f\u81e8\u5e8a\u9805\u76ee\uff0cIntellia\u6709\u671b\u7372\u5f97\u91cc\u7a0b\u7891\u4ed8\u6b3e\u8207\u92b7\u552e\u5206\u6210\u3002<\/li>\n<\/ul>\n<\/li>\n<li><strong>\u512a\u52e2<\/strong>\uff1a\u6280\u8853\u9a57\u8b49\u65e9\uff0c\u5408\u4f5c\u5925\u4f34\u5be6\u529b\u5f37\u52c1\uff0c\u7ba1\u7dda\u8986\u84cb\u591a\u500b\u9069\u61c9\u75c7\u3002<\/li>\n<\/ul>\n<h3>2. CRISPR Therapeutics<\/h3>\n<ul>\n<li><strong>\u5275\u59cb\u4eba<\/strong>\uff1a\u8afe\u734e\u5f97\u4e3bEmmanuelle Charpentier\u4e8e2013\u5e74\u806f\u5408\u5275\u7acb\u3002<\/li>\n<li><strong>\u91cc\u7a0b\u7891<\/strong>\uff1a2023\u5e7412\u6708\u8207\u798f\u6cf0\u88fd\u85e5\uff08Vertex\uff09\u63a8\u51fa\u5168\u7403\u9996\u6b3eCRISPR\u7642\u6cd5<strong>Casgevy<\/strong>\uff0c\u7372\u6279\u6cbb\u7642\u942e\u72c0\u7d30\u80de\u75c5\u8207\u8f38\u8840\u4f9d\u8cf4\u578b\u03b2\u5730\u4e2d\u6d77\u8ca7\u8840\u3002<\/li>\n<\/ul>\n<ul>\n<li><strong>\u7814\u767c\u7ba1\u7dda\uff1a<\/strong>\n<ul>\n<li><strong>\u540c\u7a2e\u7570\u9ad4<\/strong><strong>CAR-T<\/strong><strong>\u7642\u6cd5\uff1a<\/strong>CTX112\u8207CTX131\u9032\u5165\u81e8\u5e8a\uff0c\u5c6c\uffff\u7121\u9700\u5b9a\u5236\u5316\u6539\u9020\u6216\u500b\u6027\u5316\u8abf\u6574\u7684\u73fe\u6210\uff08off-the-shelf\uff09\u7642\u6cd5\u3002<\/li>\n<li><strong>\u9ad4\u5167\u57fa\u56e0\u7de8\u8f2f\u7642\u6cd5\uff1a<\/strong>\u8655\u65bc\u65e9\u671f\u81e8\u5e8a\u7814\u7a76\u968e\u6bb5\u3002<\/li>\n<li><strong>1<\/strong><strong>\u578b\u7cd6\u5c3f\u75c5\u7642\u6cd5\uff1a<\/strong>2025\u5e74\u516c\u4f48\u81e8\u5e8a\u8a66\u9a57\u9032\u5c55\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li><strong>\u512a\u52e2<\/strong>\uff1a\u9996\u500b\u5546\u696d\u5316CRISPR\u7642\u6cd5\u843d\u5730\uff0c\u73fe\u91d1\u6d41\u6f5b\u529b\u5927\uff0c\u5408\u4f5c\u65b9\u798f\u6cf0\u5177\u5099\u5f37\u5927\u92b7\u552e\u7db2\u7d61\u3002<\/li>\n<\/ul>\n<h3>3. Beam Therapeutics<\/h3>\n<ul>\n<li><strong>\u5275\u59cb\u4eba<\/strong>\uff1a\u57fa\u56e0\u7de8\u8f2f\u5148\u9a45\u5f35\u92d2\uff08Feng Zhang\uff09\u8207\u5289\u5982\u8b19\uff08David Liu\uff09\u4e8e2017\u5e74\u5275\u7acb\u3002<\/li>\n<li><strong>\u6280\u8853\u7a81\u7834<\/strong>\uff1a\u958b\u767c<strong>\u583f\u57fa\u7de8\u8f2f<\/strong>\uff08Base Editing\uff09\uff0c\u4ee5\u201c\u5206\u5b50\u925b\u7b46\u201d\u7cbe\u51c6\u62b9\u9664\u548c\u6539\u5beb\uff0c\u800c\u975e\u6572\u9664\u8b8a\u7570\uff0c\u907f\u514d\u50b3\u7d71CRISPR\u7684DNA\u96d9\u93c8\u65b7\u88c2\u98a8\u96aa\u3002<\/li>\n<li><strong>\u6838\u5fc3\u7ba1\u7dda<\/strong>\uff1a\n<ul>\n<li><strong>BEAM-302<\/strong>\uff1a\u91dd\u5c0d\u03b1-1\u6297\u80f0\u86cb\u767d\u9176\u7f3a\u4e4f\u75c7\uff08AATD\uff09\u7684I\/II\u671f\u81e8\u5e8a\u6578\u64da\u7a4d\u6975\u3002<\/li>\n<li><strong>BEAM-101<\/strong>\uff1a\u8655\u65bc\u65e9\u671f\u81e8\u5e8a\u968e\u6bb5\uff0c\u6cbb\u7642\u942e\u72c0\u7d30\u80de\u75c5\u3002<\/li>\n<li><strong>BEAM-301<\/strong>\uff1a\u91dd\u5c0d\u7cd6\u539f\u8caf\u7a4d\u75c71a\u578b\u7684\u7f55\u898b\u75c5\u7642\u6cd5\u3002<\/li>\n<\/ul>\n<\/li>\n<li><strong>\u512a\u52e2<\/strong>\uff1a\u6280\u8853\u8fed\u4ee3\u6f5b\u529b\u5927\uff0c\u9069\u61c9\u75c7\u805a\u7126\u9ad8\u672a\u6eff\u8db3\u9700\u6c42\u9818\u57df\u3002<\/li>\n<\/ul>\n<h2>\u7d50\u8a9e<\/h2>\n<p>\u57fa\u56e0\u7de8\u8f2f\u8cfd\u9053\u8655\u65bc\u7206\u767c\u524d\u591c\uff0c\u4e0a\u8ff0\u4e09\u5bb6\u516c\u53f8\u5206\u5225\u4ee3\u8868<strong>\u9ad4\u5167\u7de8\u8f2f<\/strong>\uff08Intellia\uff09\u3001<strong>\u9996\u6b3e\u5546\u696d\u5316<\/strong>\uff08CRISPR\uff09\u8207<strong>\u6280\u8853\u8fed\u4ee3<\/strong>\uff08Beam\uff09\u7684\u5dee\u7570\u5316\u8def\u5f91\u3002\u5c0d\u98a8\u96aa\u627f\u53d7\u80fd\u529b\u8f03\u5f37\u7684\u6295\u8cc7\u8005\uff0c\u53ef\u5c07\u5176\u4f5c\u70ba\u201c\u57fa\u56e0\u7d44\u9769\u547d\u201d\u9577\u671f\u4f48\u5c40\u7684\u4e00\u90e8\u5206\uff0c\u5206\u4eab\u751f\u7269\u79d1\u6280\u985b\u8986\u6027\u5275\u65b0\u7684\u7d05\u5229\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>2020\u5e74\uff0c\u7f8e\u570b\u751f\u7269\u5316\u5b78\u5bb6Jennifer Doudna\u8207\u6cd5\u570b\u5fae\u751f\u7269\u5b78\u5bb6Emmanuelle Charpent [&hellip;]<\/p>\n","protected":false},"author":27,"featured_media":569422,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[1522,431],"tags":[809,927,644,564],"class_list":["post-569427","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-1522","category-trends-strategies-zh-hant","tag-809","tag-927","tag-644","tag-564","sectors-life-science-zh-hant","locations-us-zh-hant","exchange-nasdaq-zh-hant"],"acf":[],"_links":{"self":[{"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/posts\/569427","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/users\/27"}],"replies":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/comments?post=569427"}],"version-history":[{"count":3,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/posts\/569427\/revisions"}],"predecessor-version":[{"id":569430,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/posts\/569427\/revisions\/569430"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/media\/569422"}],"wp:attachment":[{"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/media?parent=569427"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/categories?post=569427"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nai500.com\/zh-hant\/wp-json\/wp\/v2\/tags?post=569427"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}