Innovent Biologics of Suzhou has begun a US Phase I trial of its anti-CD47 mAb candidate (IBI188) in patients with advanced malignant tumors. By binding to the CD47 antigen on tumor cells, IBI188 is expected to block the CD47-SIRPα signaling pathway, inhibit the “do not eat me” signal, and promote the phagocytosis of tumor cells by macrophages. Innovent called IBI188 a “pivotal product in our pipeline of cancer immunotherapies.”
Source: China Biotoday
